The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.

There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

The invention describes a device comprising at least one emitter of P-waves and/or S-waves, preferably shear waves, more preferably axisymmetric waves, and at least one wave receiver, wherein the receiver or receivers are disposed concentrically, and the disposition of the emitters and receivers allows same to simultaneously come into direct contact with a specimen, the structure of which it is desired to characterise. Also described is a method for characterising the spatial distribution of mechanical parameters of a specimen, based on the emission of shear waves and the subsequent reception thereof.

A diagnostic system to analyze imaging data includes a memory configured to store hybrid imaging data of a tissue sample. The system also includes a processor operatively coupled to the memory and configured to generate a four quadrant plot based on the hybrid imaging data. Each point in the four quadrant plot corresponds to an image voxel of the tissue sample. The processor is also configured to determine one or more angle values and one or more distance values for image voxels in the four quadrant plot. The processor is further configured to identify one or more characteristics of the tissue sample based at least in part on the one or more angle values and the one or more distance values. The processor is further configured to perform a matrix analysis of the data, which can be used to identify the one or more characteristics of the tissue sample.

Methods and systems are provided for analyzing diffusion weighted images (DWI) using impeded diffusion fraction models for quantitative imaging diagnostic assay of cancer, such as glandular tissue cancers. The Impeded diffusion fraction models are tissue and cancer independent and generate a single score representative of multi-compartment diffusion fractions occurring within each voxel of a DWI image.

The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor-associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characterisitic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions.

An apparatus and method are provided for pelvic imaging using a saddle shaped magnetic resonance imaging system. The apparatus includes an array of electropermanent magnets having a longitudinal length that is longer than a width so that the subject may straddle the length of the array and sit on it

A device for detecting the characteristics of the prostate includes: an insertion element that is intended to be inserted through the anus into a subject’s rectum, a pressure sensor which is mounted on an expandable element and which is configured to detect the elasticity of the prostate tissues of the subject and/or at least a morphological and/or dimensional characteristic of the prostate of said subject, the expandable element which is configured to assume a first condition, in which it is housed in the insertion element, and a second a condition in which the pressure sensor is brought into contact with the prostate, an extractor, associated with the insertion element, which remains external to the anus of the subject, and an introducer element configured to be inserted inside the anus of the subject for stabilization of the device with respect to the anus of the subject.

Devices and methods are disclosed for determining prostatic urethral length. A balloon catheter subassembly is in fluid communication between an inner cavity of a syringe body and an expandable balloon is positioned at a distal end of the balloon catheter subassembly. An adapter secured to the syringe body having a syringe plunger includes a lock that engages the syringe plunger at a predefined position with respect to the syringe body corresponding to a desired inflation state of the expandable balloon. Prostatic urethral length can then be determined using markings indicating distance from the expandable balloon.