Aspects of the methods include volumetrically imaging testicular tissue by optical coherence tomography to identify a testicular tissue location that is likely to contain sperm; and m-mode scanning using optical coherence tomography the identified testicular location to determine whether sperm are at least likely to be present at the location. Methods may further include harvesting sperm from the location, e.g., for use in in vitro fertilization. Also provided are devices and systems for practicing the methods.

Diagnostic devices for diagnosing male infertility and associated methods are described herein. In one aspect, a diagnostic device can include a thermally conductive probe configured to contact a Scrotal-Testes (ST) Complex of a patient; a thermally insulative housing detachably coupled to the thermally conductive probe; and a base defining a cavity, the base including: a thermal sensor positioned within the cavity and detachably coupled to a bottom surface of the thermally conductive probe; at least one processor in electronic communication with the thermal sensor and positioned within the cavity; and a receptacle formed by an exterior surface of the base and detachably coupled to the thermally insulative housing.

A smart underwear (7) system that enables the detection of varicocele disease and the follow-up of varicocele patients, characterized by comprising: at least 2 temperature sensors (5) that enable the temperature of the right and left testicles to be measured, and microcontroller (2), for evaluating the data received from the temperature sensors (5) and, when a certain temperature value is exceeded, warning the user to bring his testicles to the appropriate temperature by means of the vibration motor (3), providing information to the user and/or doctor via SMS and e-mail when the testicular temperature exceeds the specified temperature, transferring and monitoring temperature and disease-related data to the cloud service.

A portable medical diagnostic device (100) to collect and analyze one or more biological specimen of a user is provided. The device (100) includes a housing having an interactive display (102) and a keypad (104). The keypad (104) comprises a plurality of selectable keys (106-1 or 106-2). The device (100) includes one or more biological specimen collection modules (108) operatively connected to the housing to receive at least one biological specimen of the user. One or more biological specimen collection modules (108) are communicably coupled with at least one selectable key of the selectable keys (106-1 or 106-2). The device (100) includes one or more sensors (110) provided in each of biological specimen collection module (108), configured to analyze at least one biological specimen received in the associated biological specimen collection module to determine one or more parameters of the biological specimen to be displayed on the interactive display (102).

The present disclosure provides methods for identifying a patient for varicocele correction. The method includes using the CAP-Score™ Assay to assess whether fertility is affected by the varicocele. The present disclosure also provides methods for identifying a reproductive approach inpatients suffering from varicocele. The method includes using the CAP-Score™ Assay to identify and administer the reproductive approach.

This invention relates to apparatus and method for detection of human skin lesion malignancy. The method relies on two independent wavelengths regions: (a) visible and Near IR circa (0.4-1.3 um); (b) Far Infrared (6-12 um). The visible and NIR wavelengths will analyze sub-skin scattering and absorbance to detect structural and diffusion abnormalities, and the FIR wavelengths will monitor the thermal blood perfusion, as reflected by monitoring temperature variation of suspected region. An apparatus according to the present invention would comprise a cooling/heating component which encloses the suspected area, MIR camera or thermal sensors, visible and NIR camera. Evaluation of the rate of the skin temperature changes and propagation in the suspected area will enable to detect increased blood perfusion and metabolic heat, identifying alarming signals related to skin diseases. Parallelly, the sub-skin density and coagulation will be analyzed by peripheral illumination. Evaluation procedure will include image analysis and artificial intelligence to enhance the detection capabilities. Using two independent technologies minimizes the false-negative detection and increases sensitivity and specificity. This invention relates to different body parts without limitations.

A testicular volume measuring device has a container, a lid, a sealing ring, and a plurality of indicia. The lid is removably attached atop the container, and the plurality of indicia is positioned on a lateral wall of the container, which is constructed of a transparent material and delineates an internal cavity. The lid has multiple lid members, which are removably attached to each other. The lid members have cutouts which form a central aperture on the lid, within which the sealing ring is secured during use. One or more testicles may be placed through the sealing ring, around which the lid members are affixed, and the lid is attached atop the container. Fluid volume measurements using the indicia before and after placement of the testicles into a quantity of fluid contained within the cavity enable measurement of the volume of the testicles through fluid displacement.

An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.

A tactile sensing system includes at least a stretchable strain sensing layer, an inflatable reservoir, and a means for detecting strain in the stretchable strain sensing layer. The tactile sensing layer may be configured as a tumor detection system by configuring the inflatable reservoir to apply pressure to at least part of a tissue in conjunction with an anatomical contact structure and the stretchable strain sensing layer to be in contact with a region of the surface of the tissue.

A pressure sensing system includes at least two pressure sensing layers. The first pressure sensing layer includes a first sensing system configured in a layer, a first layer of foam having a Young's modulus and mounted between a first sensing system configured in a layer, and a second sensing system configured in a layer; at least a second pressure sensing layer including the second sensing system configured in a layer, and a second layer of foam having a Young's modulus that is greater than the Young's modulus of the first layer of foam and mounted between the second sensing system configured in a layer and a rigid substrate having a Young's modulus greater than the layer of the first sensing system, the first layer of foam, the layer of the second sensing system, and the second layer of foam. The pressure sensing system thereby defines a multi-layer pressure sensing system.