An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).

A brace configured for attachment to a joint of a subject is provided. The brace includes a first arm having a first end and a second end. The brace includes a second arm having a first end and a second end. The brace includes a hinge assembly coupling the first end of the first arm with the first end of the second arm such that the first arm and the second arm are movable to different relative angular orientations. The brace includes a potentiometer coupled to the hinge assembly. A method of monitoring a relative angular orientation of a first arm of a brace relative to a second arm of the brace is also provided. The method includes monitoring an output of a potentiometer coupled to one of the first arm and the second arm.

The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.

A cartilage conduction system may include (1) a transducer that generates mechanical energy and (2) a functionally graded material (FGM) interface dimensioned to be coupled between the transducer and cartilage located on an outer ear of a user, wherein the FGM interface (1) exhibits a gradation of at least one characteristic from one side of the FGM interface to another side of the FGM interface and (2) facilitates transferring the mechanical energy across the gradation of the characteristic from the transducer to the cartilage. Various other systems and methods are also disclosed.

The present disclosure directs to a method for image processing. The method may include obtaining scanning data of a spine of a subject, determining one or more centrum parameters of each of a plurality of centrums of the spine based on the scanning data, and identifying at least one intervertebral disc based on the one or more centrum parameters.

Each of the at least one intervertebral disc may be between a pair of neighboring centrums of the plurality of centrums. The method may include determining an intervertebral disc reconstruction protocol of each of the at least one intervertebral disc, determining a target intervertebral disc of the at least one intervertebral disc, and reconstructing one or more images of the target intervertebral disc based on an intervertebral disc reconstruction protocol of the target intervertebral disc. The intervertebral disc reconstruction protocols may relate to MPR.

A method of preparing an interpositional implant suitable for a knee. The method includes determining a three-dimensional shape of a tibial surface of the knee. An implant is produced having a superior surface and an inferior surface, with the superior surface adapted to be positioned against a femoral condyle of the knee, and the inferior surface adapted to be positioned upon the tibial surface of the knee. The inferior surface conforms to the three-dimensional shape of the tibial surface. The implant may be inserted into the knee without making surgical cuts on the tibial surface. The tibial surface may include cartilage, or cartilage and bone.

Some aspects of the present disclosure relate to ultrashort-echo-time (UTE) imaging. In one embodiment, a method includes acquiring UTE imaging data associated with an area of interest of a subject. The acquiring comprises applying an imaging pulse sequence with a three-dimensional (3D) spiral acquisition and a nonselective excitation pulse. The method also includes reconstructing at least one image of the area of interest from the acquired UTE imaging data.

Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.

A joint image unfolding apparatus, a joint image unfolding method, and a non-transitory computer readable recording medium storing a joint image unfolding program are provided to make it possible to check information regarding the entire cartilage in a joint with high accuracy. An image obtaining unit (21) obtains a three-dimensional image of a joint having cartilage. An unfolding unit (23) unfolds the cartilage included in the three-dimensional image with reference to a specific reference axis in the joint to generate an unfolded image.