Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.

Provided is a system for estimating a subjective evaluation by an estimation subject. This system for estimating a subjective evaluation by an estimation subject comprises: a reception means that receives feature data of a biosignal acquired from the estimation subject; a storage means that stores a plurality of feature templates extracted from a plurality of biosignals acquired from a plurality of subjects to be modeled including a first subject to be modeled and a second subject to be modeled, or that stores a plurality of models trained using said feature templates; and an estimation means that estimates a subjective evaluation by the estimation subject on the basis of the feature data and the plurality of feature templates or the plurality of models.

To provide objective indications of the progression of peripheral neuropathy of patients, a transmitter apparatus is utilized to produce reproducible pulse signals to specified locations on the human body to determine a minimum level of stimulation necessary to elicit a consciously detectable sensation through the generation of a series of pulse signals of varying intensities, and the recordation of the number of pulse signals felt by the patient. Moreover, the nerve velocity of the patient is additionally determined for a patient via the transmitter apparatus and a receiver apparatus detecting body-signals passing along a nerve within the patient and corresponding to the pulse signals applied to the patient. The results of these tests are recorded over time, thereby enabling generation of patient-specific models indicative of the progression of the patient's peripheral neuropathy over time.

The various embodiments herein disclose a method and a system with a portable handheld diagnostic device for detecting and/or monitoring the prognosis of nerve impairment or diabetic peripheral neuropathy. The system provides a multi-parameter diabetic neuropathy-screening device to perform a combination of tactile threshold test, vibration threshold test, thermal threshold test and contactless skin-temperature measurement. The present invention provides a smartphone application that helps a user to operate/control the device, store and share the results. The smartphone application interacts with the hardware modules in the device and guides the user to perform the various tests. Further, the neuropathy diagnostic system provides a wireless feedback button that enables the subject to respond to various sensations during the course of the test.

Provided herein are methods to predict pain sensitivity and pain intensity to prolonged pain in a subject. Electroencephalograms are recorded in a pain-free state or, alternatively, in a pain-free state and after applying a prolonged pain stimulus in a prolonged pain state. Pain-free and prolonged pain peak alpha frequencies or ΔPAF are measured. These values correlate negatively with the likelihood of increased pain sensitivity and increased pain intensity. Also provided is a method for predicting a likelihood of chronic pain in a subject after a medical procedure and designing a plan to treat the chronic pain.

Provided are a pain measuring device and a main measuring method. More particularly, the pain measuring device may control a temperature provided from a temperature stimulator, receive, from a user input portion, a user input for recording a level of stimulation according to the temperature, obtain, from a camera, image data representing a change in an external shape of a user according to the stimulation, obtain, from a sensor, biodata representing a biological change of the user according to the stimulation, and obtain information about a level of pain experienced by the user according to the stimulation based on data corresponding to the user input, the image data, and the biodata.

The present invention relates to a control and command method for a device for thermal stimulation of animal or human tissue (1), said method being characterised in that it includes: determining a neutral temperature applied to the tissue (1), thermally adjusting the neutral temperature by activating a control loop, determining a cold or hot thermal stimulation temperature to be applied to the tissue (1), in alternation with the neutral temperature; determining a duration and a frequency of the thermal stimulations; in the case of an instruction to initiate the stimulation temperature by activating a control loop and by deactivating the control loop on the neutral temperature; and synchronising a physiological recording with the thermal stimulation.

A training and simulation assembly for the learning of deliberate control of a specified body part by a test subject contains an electrode cap, which has a number of electrodes, and an evaluation unit, which is configured to measure voltages present at the electrodes and to provide measurement results as EEG measurement data. The evaluation unit analyzes the EEG measurement data for the presence of a mental act and to determine a correspondence value, which indicates the correspondence of the EEG measurement data with reference values defined by the mental act. A control unit and a simulation unit are provided. The simulation unit stimulates the body of the test subject at a specified point of the body and/or to trigger a motion. The control unit controls the stimulation unit and the ability to apply an indicating stimulus to the body part by the stimulation unit.

A method of determining a predisposition to contact lens discomfort in a patient is provided, comprising determining a detection threshold of the patient by delivering a cool mechanical stimulus to the cornea of the patient, optionally applying a series of cool mechanical stimuli to the cornea of the patient, and classifying the patient as being predisposed to contact lens discomfort if the detection threshold is at or below a cut-off value predetermined to be associated with predisposition to contact lens discomfort and/or the patient does not adapt to the series of cool mechanical stimuli.

Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.