An intracranial pressure monitoring device includes a housing defining a first internal chamber, a plurality of strain gauges disposed on an inner surface of a diaphragm defined by a wall of the first internal chamber, a device for generating orientation signals, and circuitry coupled to the plurality of strain gauges and to the device. The circuitry is configured to generate intracranial pressure data from signals received from the plurality of strain gauges, generate orientation data based on the orientation signals received from the device, and store the intracranial pressure data and the orientation data in a computer readable storage such that the intracranial pressure data and orientation data are associated with each other.

A multi-site probe for interfacing with the central nervous system includes one more structures disposed perpendicularly on a backing layer, where each structure includes a braided sleeve over a flexible or rigid core, and a delivery-vehicle. The structures may include optrodes and electrodes. The location of the probe may be determined through the application of combinatorics.

Disclosed is a drug injection device that is implanted between the skull and the subcutaneous layer of an animal. The disclosed drug injection device includes: a main body that is positioned on the skull and implanted and fixed in the subcutaneous layer; a guide member that guides a trocar such that the drug is injected into brain parenchyma inside the skull of the animal; a cover member that is installed inside the main body and connected to the guide member in the center and has a hole for guiding drug injection trocar so as to be inserted; and a sealing member that is installed between the main body and the cover member and prevents reverse flow of drugs and the introduction of foreign substances.

A subdural sensor includes: a substrate formed of a flexible material; and at least one type of sensor part mounted on the substrate. The substrate has an elongated shape, and includes: a sensor area in which the sensor part is mounted and a wiring pattern connected to the sensor part is formed; a wiring area contiguous with the sensor area, the wiring pattern extending in the wiring area; and a connector area contiguous with the wiring area, the connector area being an area on which a connector to be connected to the wiring pattern extending from the wiring area is mounted. A tip part of the sensor area has a planar shape that curves convexly toward an outer periphery, and a side shape that curves toward a first surface, the first surface being on the side of a dura mater when the subdural sensor is inserted into the subdural space.

Brain drainage device having a rod-shaped hollow body with an inner drainage channel for insertion through the cranium into the brain, a first sensor arrangement with at least one sensor for measuring a physical parameter, and a signal interface; wherein the rod-shaped hollow body has a first region A which, in the applied state, is designed to protrude into the ventricle situated in the brain; wherein the rod-shaped hollow body has a second region B, which is arranged proximally from the first region, wherein the second region is designed to lie in the region of the brain mass in the applied state; wherein the first sensor arrangement is arranged in the second region in order to measure a physical parameter of the brain mass; wherein the first sensor arrangement is connected to the signal interface such that measurement data determined by the first sensor arrangement are transmitted to a measuring system that is to be connected.

A low-profile cranial device is adapted for covering and protecting electrical leads. The cranial device includes a static cranial implant shaped and dimensioned for housing a functional neurosurgical implant including electrical leads. The static cranial implant includes an outer first surface along an exterior side of the static cranial implant, an inner second surface along an interior side of the static cranial implant, and a peripheral wall extending between the outer first surface and the inner second surface. A cavity is formed along the outer first surface of the static cranial implant, the cavity being shaped and dimensioned to house the functional neurosurgical implant in a manner allowing the electrical leads to be wound up to store excess electrical lead length.

A system provides a burr hole cap assembly configured to secure a position of a lead implanted through a burr hole in a cranium of a patient. One or more electrodes are coupled to one or more components of the burr hole cap assembly. The one or more electrode is disposed within the burr hole cap assembly for sensing signals within a brain of the patient or stimulating a portion of the brain of the patient.

Brain drainage device having a rod-shaped hollow body with an inner drainage channel for insertion through the cranium into the brain, a first sensor arrangement with at least one sensor for measuring a physical parameter, and a signal interface; wherein the rod-shaped hollow body has a first region A which configured to protrude into the ventricle situated in the brain; wherein the rod-shaped hollow body has a second region B, which is arranged proximally from the first region, wherein the second region is configured to lie in the region of the brain mass; wherein the first sensor arrangement is arranged in the second region in order to measure a physical parameter of the brain mass; wherein the first sensor arrangement is connected to the signal interface such that measurement data determined by the first sensor arrangement are transmitted to a measuring system.

Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject. Other aspects are directed to various related systems and methods of obtaining diagnostic information from, and/or administering therapy to, a subject.

A device is configured to receive a catheter. The catheter may be a catheter of a ventriculoperitoneal shunt or an external ventricular drain. The device includes (ii) an upper flange having an opening, and (ii) elongate body defining a lumen in communication with the opening. The catheter may be inserted through the opening and the lumen. The device includes an electrode disposed on the elongate body. When the device is implanted in a subject, the upper flange rests on a skull of the subject adjacent to a burr hole, the elongate body is inserted through the burr hole, and the electrode is positioned intracranially in the subject.