The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being pivotally connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.

An upper gastrointestinal bleeding monitoring system includes a detection device and a signal processing device to determine bleeding condition of an upper gastrointestinal tract by using relation of time and intensity ratios of RGB three primary colors. The detecting device is placed to the upper gastrointestinal tract of a patient via his/her mouth or nasal passage and then stay the upper gastrointestinal tract for several days for detection of bleeding. The signal processing device may receive and display signal from the detection device to help medical professionals check if bleeding occurs in an upper gastrointestinal tract. Moreover, a procedure of determination of bleeding in an upper gastrointestinal tract with the upper gastrointestinal bleeding monitoring system is described.

The present disclosure is in the field of gastric resident systems. A device for extended retention in a stomach is provided. The device includes: first, second, and third arms, the second and third arms being connected to respective ends of the first arm. The device is configured to transform between a compressed configuration and an expanded configuration. The device further includes a biasing member configured to bias the device into the expanded configuration whereby the second and third arms are configured to mechanically engage each other to retain the system in the expanded configuration.

A medical apparatus configured to neuromodulate tissue and/or record patient information is provided. The apparatus includes an external system to transmit transmission signal(s), each signal having at least power or data, and an implantable system to receive the transmission signal(s). The data transfer between the external and implantable systems is asynchronous. The external system includes external antenna(s) to transmit a transmission signal. The transmission signal is an amplitude modulated signal modulated by varying a load on the external antenna(s) that causes an impedance mismatch prior to amplifying the signal for transmission. An implantable device includes implantable antenna(s) to receive the transmission signal. The implantable system comprises a receiver to receive the transmission signal from the implantable antenna(s), implantable transmission module(s) to transmit data to the external system, and a variable load connected to the implantable antenna(s). Data is transmitted by varying the load.

Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

Methods for electrically stimulating body tissues to improve function or reduce symptoms provide an electrical stimulation system having two or more electrodes that are capable of being switched independently from a hyperpolarizing (depolarizing) state to a hypopolarizing state. Multiple combinations of hyperpolarizing electrodes and hypopolarizing electrodes are created by polarity switching to determine a polarity configuration having the best performance as determined by symptom reporting and clinical diagnostic tests. Polarity switching is triggered manually or is programmed to be switched automatically. Determining the configuration providing electrical stimulation resulting in the greatest benefit allows the system to be operated with one or more electrodes in a hypopolarizing state, thereby reducing energy requirements, tissue tolerance, and tissue fatigue.

A system and method are provided for securing an ingestible electronic device to a pharmaceutical product without damaging the ingestible electronic device. The product includes the ingestible electronic device being placed on the product in accordance with one aspect of the present invention, in accordance with another aspect of the present invention, the ingestible electronic device is placed inside the product. Various embodiments are disclosed in accordance with the present invention for protecting and/or coating of the electronic marker as well as securing the ingestible electronic device onto the product.

An upper gastrointestinal bleeding monitoring system includes a detection device and a signal processing device to determine bleeding condition of an upper gastrointestinal tract by using relation of time and intensity ratios of RGB three primary colors. The detecting device is placed to the upper gastrointestinal tract of a patient via his/her mouth or nasal passage and then stay the upper gastrointestinal tract for several days for detection of bleeding. The signal processing device may receive and display signal from the detection device to help medical professionals check if bleeding occurs in an upper gastrointestinal tract. Moreover, a procedure of determination of bleeding in an upper gastrointestinal tract with the upper gastrointestinal bleeding monitoring system is described.

A feeding tube position confirmation device 102, operable to confirm the position of a predetermined portion of a medical feeding tube in a predetermined portion of a human or animal body, the position confirmation device comprising an optical waveguide 106 dimensioned to be insertable into the lumen of the feeding tube, the optical waveguide having a sensing distal end 108 comprising a distal end material and a sensing material mixed with the distal end material, the sensing material operable to provide a change in optical properties at the distal end 110 of the optical waveguide dependent on the environment to which the sensing distal end 108 of the waveguide is exposed. The sensing material may comprise a reflective material. Methods of manufacture and use of such devices are also described.

Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of tracking and locating the same are provided.