Systems and methods for cardiac pacing are provided, where a pacing lead is placed at or near the bundle of His. A method for pacing a heart of a patient comprises: introducing a sheath to vasculature of the patient; steering the sheath within a coronary sinus in the heart to lodge a distal end of the sheath to a target location proximal to the bundle of His above a septum separating a left ventricle and a right ventricle of the heart; advancing a pacing lead through a lumen of the sheath to the target location; coupling the pacing lead to cardiac tissue at the target location; removing the sheath; and electrically pacing the bundle of His using the pacing lead.

An image synthesis unit of an X-ray imaging apparatus is configured to correct a synthesis target image or a transparent image based on movement information of a feature point and movement information of a pixel and generate a synthesized image by synthesizing a corrected synthesis target image and a transparent image or synthesizing a synthesis target image and a corrected transparent image.

Two major treatment strategies employed in fighting non-small cell lung cancer (NSCLC) are tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). The choice of strategy is based on heterogeneous biomarkers expressed by the lung tumor tissue. A major challenge for molecular testing of these biomarkers is the insufficiency of biopsy specimens from patients with advanced NSCLC. Disclosed herein is a method for predicting a response to immune-checkpoint blockade immunotherapy. The method generally involves imaging the subject with positron emission tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with computed tomography to produce .sup.18F-FDG PET/CT images of the tumor, analyzing the images using PET, CT, and Kulbek Leibler Divergence statistical (KLD) features or, alternatively using deep leaning such as Neural Networks; generating a radiomic signature from the identified features or Network characteristics; and computing a radiomic score based on the radiomic signature that is predictive of responsiveness to ICIs or TKIs.

Methods and devices for producing cavitation in tissue are provided. Methods and devices are also provided for surgical navigation, including defining a target treatment zone and navigating a focus of a therapy transducer to the target treatment zone. Embodiments are provided for co-registering a plurality of surgical imaging and navigation systems. Systems for performing Histotripsy therapy are also discussed.

Disclosed herein is a method and a system for reconstructing a three-dimensional image of an object, based on stitched images of the object obtained using multiple beams.

This invention provides a method to optimize an x-ray beam for more than one structure within the field of view. The preferred embodiment comprises a modular construction of a collimator comprising multiple materials of varying thickness. A first attenuation is performed by the first portion of the collimator to optimize a first anatomic feature and a second attenuation is performed by the second portion of the collimator to optimize a second anatomic feature.

In a multi-session imaging study, information from a previous imaging session is stored in a Binary Large Object (BLOB). Current emission imaging data are reconstructed into a non-attenuation corrected (NAC) current emission image. A spatial transform is generated aligning a previous NAC emission image from the BLOB to the current NAC emission image. A previous computed tomography (CT) image from the BLOB is warped using the spatial transform, and the current emission imaging data are reconstructed with attenuation correction using the warped CT image. Alternatively, low dose current emission imaging data and a current CT image are acquired, a spatial transform is generated aligning the previous CT image to the current CT image, a previous attenuation corrected (AC) emission image from the BLOB is warped using the spatial transform, and the current emission imaging data are reconstructed using the current CT image with the warped AC emission image as prior.

There is provided a method for registration of intravital anatomical imaging modality image data and nuclear medicine image data of a patient's heart comprising: obtaining anatomical image data including a heart of a patient outputted by an anatomical intravital imaging modality; obtaining at least one nuclear medicine image data outputted by a nuclear medicine imaging modality, the nuclear medicine image data including the heart of the patient; identifying a segmentation of a network of vessels of the heart in the anatomical image data; identifying a contour of at least part of the heart in the nuclear medicine image data, the contour including at least one muscle wall border of the heart; correlating between the segmentation and the contour; registering the correlated segmentation and the correlated contour to form a registered image of the anatomical image data and the nuclear medicine image data; and providing the registered image for display.

A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and the x-ray emitter.

A radiographing system that can attach a dose index for a composition image and perform dose management in a composition image is provided. The radiographing system includes: a dose index calculation unit configured to respectively calculate dose indices from a plurality of radiographic images, an obtaining unit configured to obtain a representative dose index from among the plurality of dose indices calculated by the dose index calculation unit, and a storage unit configured to store the representative dose index together with the composition image.