Prosthetic scaffold for regenerative organization of organ tissue for organ function supplementation or replacement and a method for making the prosthetic scaffold by physical vapor deposition of same.

An orbital implant adapted for attachment to the very thin bone at the orbit rim (502), such as the zygomatic and frontal bone margin at the supero-lateral aspect (501) of the orbit (503), for the attachment of an eye prosthesis directly to distal ends of inwardly convergently orientated transdermal abutments. The orbital implant has a baseplate (100) having an orbit radius curvature and an orbit rim curvature and a plurality of microfixation apertures therethrough and the plurality of transdermal abutments are located at an inner edge of the baseplate (100).

A method (100) of forming an ocular prosthesis (13) comprising: receiving (102a) three dimensional scan data of a patients eye, the three dimensional scan data including volumetric data of at least an iris region, a pupil region and a cornea region of the eye; and forming (110) an ocular prosthesis (13) by an additive manufacturing process, the ocular prosthesis (13) having a body (15) with a volume, wherein the body of the prosthesis includes a three dimensional iris region (23), a three dimensional pupil region (25) and a three dimensional cornea region (26), and the volumetric data determines the size and shape of the iris region (23), the pupil region (25) and the cornea region (26) of the prosthesis (13).

The Nucleo-reticular Multi-cell Dual-system Eye Implant consists of a spherical structure with calculated and variable axial length depending on the needs required by the orbital eye socket, composed of a cell mesh with alternative designs that in turn, makes up the MMM System, in which suturing is provided in any technique, either in cases of evisceration or enucleation. Thanks to its multi-cell structural design, it favors its placement and reduces the risk of migration, extrusion, exposure and extraction. As it is an arrangement with structural holes, it provides a higher percentage of the volume for its vascularization; it also houses inside a Reticular Fibrovascular Core System, which has a structure based on multilevels equipped with micro-reticular tissue and an intra-level communication based on filaments; with the capacity to contain medicines and/or technology by presenting a dual-system of two screw-on pieces, being able to manufacture in different structural designs and biocompatible materials. The C100 model made of polylactic acid (PLA), an ideal material for implants, consists of 100 oval cells. Since it is a light eye implant, it prevents depressure due to settlement or gravity and it can be manufactured in any size.

A movable ocular prosthetic apparatus and related systems and methods for moving an ocular prosthetic include a support member. An ocular prosthetic is mounted to the support member, wherein the ocular prosthetic is movable about the at least two axes of rotation. A control system controls a movement of the ocular prosthetic based on a sensed movement of a pupil of an eyeball of a human being.

An artificial eye for use with an animatronic figure or a robot. The artificial eye includes an outer shell formed with a wall defining a spherical inner void space. The outer shell includes a transparent outer or forward portion or half joined with a rear portion or half. The artificial eye includes an inner eye or sphere including a hollow, semi-spherical shell, and the inner eye is positioned in the inner void space of the outer shell. The artificial eye includes an electromagnetic drive positioned within the hollow, semi-spherical shell of the inner eye. The electromagnetic drive supports the inner eye a distance from inner surfaces of the outer shell wall, and the drive includes a pivot joint such as a gimbal operable to pivot the inner eye. The inner eye is supported by a central pivot joint and driven by components centrally located and hidden within the inner eye.

A method for manufacturing a liquid crystal polymer-based electrode array for a neural implant, according to the present invention, can comprise the steps of: forming a seed layer on a liquid crystal polymer substrate; forming a plating mold having a pattern selectively exposing a part of the upper part of the seed layer; plating an electrode material on the exposed seed layer by using the plating mold as a plating barrier layer; forming an electrode by removing the plating mold and the seed layer therebelow; embedding the electrode by compressing a liquid crystal polymer cover layer on the electrode; and forming an electrode site exposing the upper part of the electrode by selectively removing a part of the liquid crystal polymer cover layer.

Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.

The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and method sof treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

A Super System on Chip (SSoC) coupled with a photonic neural learning processor (PNLP), one or more quantum bits (qubits) and a machine learning algorithm for ultrafast data processing, image processing/recognition, deep learning/meta-learning and self-learning is disclosed. The Super System on Chip (SSoC) is interconnected/coupled electrically and/or optically in two-dimension (2-D) or in three-dimension (3-D).