A corneal device comprising a base surface and a top surface, and having a water content ranging from about 78%-92% (w/w), inclusive. The corneal device can be used to treat, for example without limitation, ectatic corneal disease by supporting corneal structure weakened by the disease and/or changing an anterior curvature of the cornea.

Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using supramolecular complexes that form a defined gel structure in situ. Such gels can serve as cellular or acellular matrices with or without certain encapsulated therapeutic factors to facilitate tissue regeneration such as multilayered re-epithelialization of wounded corneal stromal tissue.

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

An apparatus includes a flexible container and a port. The container includes a first layer coupled to a second layer to define a storage volume within which a tissue specimen can be contained. The first layer has a first stiffness and the second layer has a second stiffness. An edge of the first layer is spaced apart from an edge of the second layer to define an opening into the storage volume. The edges of the first and second layer form a peelable seal that hermetically seals the storage volume such that the first layer can be peeled away from the second layer to expose the storage volume. The port is coupled to the flexible container and allows fluid communication between the storage volume and an external volume.

An ophthalmic lens system for reducing the risk of progression of a myopic eye by selectively maintaining, inducing or creating asymmetry of the peripheral retinal profile for the eye. A method for reducing the risk of progression of myopia comprising determining the magnitude of asymmetry of the on-axis/off-axis refractive error profile or eye length profile of the eye and providing an ophthalmic lens system that corrects for and provides acceptable on-axis vision and simultaneously controls the position of the off-axis refractive error profile or eye length profile such that resultant profile of the eye is asymmetric.

Methods of manufacturing and implanting corneal inlays, such as small diameter corneal inlays, are provided. The methods include manufacturing an implant body to have a meniscus shape with a small diameter and an index of refraction, and implanting the implant body in a corneal bed of a cornea. The inlays cause a change in an anterior surface of the cornea after implantation due to the implant body.

A storage/delivery device includes a first wall defining a well configured to receive a corneal tissue. The storage/delivery device includes a second wall configured to be positioned over the first wall and to seal the well. The second wall includes a recess configured to extend into the well to define a chamber between the first wall and the second wall. The chamber is configured to hold the corneal tissue when the second wall seals the well. A system may include the storage/delivery device above and a measurement system configured to measure the corneal tissue disposed in the well. In one example embodiment, the measurement system is an optical coherence tomography (OCT) system. In another example embodiment, the measurement system is a second-harmonic generation (SHG) or third-harmonic generation (THG) microscopy system.

Methods for treating presbyopia in a patient's eye involve inducing spherical aberration in a central area of the pupil. In embodiments, refractive properties of an eye are measured to obtain a baseline refractive correction. A lens for wearing on the eye is provided, or an optical device is implanted in the eye, or corneal tissue is removed to create spherical aberration or a distribution of spherical aberrations beyond the baseline refractive correction in the central area of the pupil. The central area of the pupil has a diameter of between 1.5 mm and 4.0 mm and has negligible spherical aberration without the treatment.

Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs), include features for reducing dysphotopsia effects, such as haloes and glare. Exemplary ophthalmic lenses may include a central zone with a first set of two echelettes arranged around the optical axis, the first set having a profile in r-squared space. A middle zone includes a second set of two echelettes arranged around the optical axis, the second set having a profile in r-squared space that is different than the profile of the first set. A peripheral zone includes a third set of two echelettes arranged around the optical axis, the third set having a profile in r-squared space that is different than the profile of the first set and the profile of the second set, the third set being repeated in series on the peripheral zone.

Contact lens that, during use, creates a hollow space between its concave internal surface and the convex external surface of the eye and contacts the corneal epithelium only for a fraction of its internal surface facing toward the eye thanks to the presence of a plurality of micro-protuberances which allow to raise the contact lens by a few micrometers with respect to the corneal surface.