A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

This disclosure provides ophthalmic implants such as sulcus implants which can comprise one or more drug delivery devices. Further provided herein are methods of using the drug delivery ophthalmic devices described herein for implantation into a subject's eye, e.g., into an eye's ciliary sulcus or capsular bag.

Methods of manufacturing and implanting corneal inlays, such as small diameter corneal inlays, are provided. The methods include manufacturing an implant body to have a meniscus shape with a small diameter and an index of refraction, and implanting the implant body in a corneal bed of a cornea. The inlays cause a change in an anterior surface of the cornea after implantation due to the implant body.

Methods for treating presbyopia in a patient's eye involve inducing spherical aberration in a central area of the pupil. In embodiments, refractive properties of an eye are measured to obtain a baseline refractive correction. A lens for wearing on the eye is provided, or an optical device is implanted in the eye, or corneal tissue is removed to create spherical aberration or a distribution of spherical aberrations beyond the baseline refractive correction in the central area of the pupil. The central area of the pupil has a diameter of between 1.5 mm and 4.0 mm and has negligible spherical aberration without the treatment.

Corneal implant (1) designed for correcting irregularities of the corneal curvature of a subject, the implant (1) having a generally dome-shaped structural body (2) configured to impose a regular curvature to the corneal portions designed to be in contact with the implant, wherein the structural body comprises an outer peripheral ring (10) and an inner reticular structure (20), wherein the inner reticular structure (20) comprises at least one first and one second series of beams (21, 22) intersecting each other, the beams (21) of the first series having a respective first end (31) connected to the outer peripheral ring (10), wherein the total area of void portions (24) within the meshes of the reticular structure (20) is between 50 and 99.9% of the surface area of the reticular structure (20).

A corneal implant designed for correcting irregularities of the corneal curvature of a subject, the implant having a dome-shaped structural body configured to impose a regular curvature to the corneal portions designed to be in contact with the implant. The structural body includes an outer peripheral ring and an inner reticular structure. The inner reticular structure includes at least one first and one second series of beams intersecting each other. The beams of the first series have a respective first end connected to the outer peripheral ring, wherein the total area of void portions within the meshes of the reticular structure is between 50 and 99.9% of the surface area of the reticular structure, wherein the beams of both the first and second series have both ends connected to the outer peripheral ring.

The invention provides a synthetic ophthalmic device comprising a porous polymeric structure; wherein said structure is in the shape of a truncated hemisphere and uses thereof in the treatment of ophthalmic conditions, diseases and syndromes.

Methods for treating presbyopia in a patient's eye involve inducing spherical aberration in a central area of the pupil. In embodiments, refractive properties of an eye are measured to obtain a baseline refractive correction. A lens for wearing on the eye is provided to create spherical aberration or a distribution of spherical aberrations beyond the baseline refractive correction in the central area of the pupil. The central area of the pupil has a diameter of between 1.5 mm and 4.0 mm and has negligible spherical aberration without the treatment.

Corneal augmentations designed for the amelioration of an abnormality of a cornea and methods of using them are disclosed. The corneal augmentations are shaped from corneal templates. The required arcuate 3-D shapes of the corneal augmentations are determined based on elevation maps of the cornea as well as measurements of a severity of the abnormality such as the maximum keratoconus, K-max. Shaping of the corneal augmentation is done using computer-controlled femtosecond lasers and laser ablation.

An ophthalmic implant for drug delivery. The implant includes a primary intracapsular device coupled to a secondary device, wherein, when implanted in a patient's eye, the primary intracapsular device is held in place by the patient's capsular bag and the secondary device is held in place by the primary intracapsular device. The implant may be inserted in the eye by injecting the primary intracapsular device into the eye either before or after attaching the secondary device to the primary intracapsular device, and subsequently positioning the joined secondary device and primary intracapsular device with the primary intracapsular device held in place by the patient's capsular bag and the secondary device held in place by the primary intracapsular device. The secondary device may be designed to hold a tertiary device that can be implanted and attached at the time of surgery or anytime postoperatively.