A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed.

A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed.

A prosthetic heart valve includes a frame, a valve, and an expansion element. The frame is movable between contracted and expanded configurations and includes first struts and second struts non-hingedly coupled together. The second struts are configured to pivot relative to the first struts as the frame moves between the contracted and expanded configurations. The valve is coupled to the frame and includes leaflets. The expansion element extends through a lumen of the first struts. The expansion element is slidable relative to the lumen of the first struts and is configured to move the frame incrementally from the contracted configuration and the expanded configuration and from the expanded configuration to the contracted configuration.

A prosthetic heart valve includes a frame, a valve, and an expansion element. The frame is movable between contracted and expanded configurations and includes first struts and second struts non-hingedly coupled together. The second struts are configured to pivot relative to the first struts as the frame moves between the contracted and expanded configurations. The valve is coupled to the frame and includes leaflets. The expansion element extends through a lumen of the first struts. The expansion element is slidable relative to the lumen of the first struts and is configured to move the frame incrementally from the contracted configuration and the expanded configuration and from the expanded configuration to the contracted configuration.

Shape memory alloys are used in aerospace structures, orthodontics, cardiovascular prosthetic devices, sensors and controllers, and many other engineering, technology, science, and other fields. The methods are described in the case of a temporary heart assist pump to illustrate the concepts, but the method applies to many other fields. The properties of shape memory alloys are used to fold or collapse and implant in the human body a device without breaking the device as it reaches body temperature or without reaching permanent plastic deformation. The properties of nitinol are also used to describe intended explantation of the device, at body temperature, from the body without breaking it. Such planned explantation may be needed in cases where the device is designed for temporary use, such as mechanical circulatory support devices intended for temporary use and then removal of all components of the device from the body. The same method can be used for devices that have not been initially designed for removal, such as stents or valves, that must later be explanted for reasons unanticipated when they were installed. The methods ensure that the devices stay within stress-strain-temperature conditions so they remain elastic, or under the upper stress plateau, or remain plastic, but always under the breaking strain, of shape memory alloys at: room or environmental conditions; cooler than environmental conditions; and at a higher temperature, or body temperature. The methods described may also be applied to other industrial applications, where shape memory alloys may be installed and removed at different temperatures. Applications in other industries, include aerospace, civil structures, mechanical structures are contemplated.

Shape memory alloys are used in aerospace structures, orthodontics, cardiovascular prosthetic devices, sensors and controllers, and many other engineering, technology, science, and other fields. The methods are described in the case of a temporary heart assist pump to illustrate the concepts, but the method applies to many other fields. The properties of shape memory alloys are used to fold or collapse and implant in the human body a device without breaking the device as it reaches body temperature or without reaching permanent plastic deformation. The properties of nitinol are also used to describe intended explantation of the device, at body temperature, from the body without breaking it. Such planned explantation may be needed in cases where the device is designed for temporary use, such as mechanical circulatory support devices intended for temporary use and then removal of all components of the device from the body. The same method can be used for devices that have not been initially designed for removal, such as stents or valves, that must later be explanted for reasons unanticipated when they were installed. The methods ensure that the devices stay within stress-strain-temperature conditions so they remain elastic, or under the upper stress plateau, or remain plastic, but always under the breaking strain, of shape memory alloys at: room or environmental conditions; cooler than environmental conditions; and at a higher temperature, or body temperature. The methods described may also be applied to other industrial applications, where shape memory alloys may be installed and removed at different temperatures. Applications in other industries, include aerospace, civil structures, mechanical structures are contemplated.

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

In one embodiment according to the present invention, a stent is described having a generally cylindrical body formed from a single woven nitinol wire. The distal and proximal ends of the stent include a plurality of loops, some of which include marker members used for visualizing the position of the stent. In another embodiment, the previously described stent includes an inner flow diverting layer.

A medical implant delivery system is described. The system can be used to deliver a variety of implants including stents and/or stent grafts. The delivery system retains the implant during delivery and detaches the implant at a target location.

A medical implant delivery system is described. The system can be used to deliver a variety of implants including stents and/or stent grafts. The delivery system retains the implant during delivery and detaches the implant at a target location.