Provided are a silicone stent (100), an implantation system, and a manufacturing method. The silicone stent (100) includes a stent body (110). The stent body (110) includes a mesh frame (112) and a silicone body (111) molded on the mesh frame (112). A circumferentially sealed space (116) is defined within the silicone body (111). A distal end and a proximal end of the silicone body (111) respectively have a distal-end opening (115) and a proximal-end opening (114) that communicate with the space (116). The mesh frame (112) circumferentially covers the silicone body (111), and runs in an axial direction of the silicone body (111). The mesh frame (112) extends from the proximal end of the silicone body (111) to the distal end of the silicone body (111).

Intravascular inflatable medical devices and their methods of manufacture and use. The inflatable medical devices may include a conduit that includes an inflatable wall, with the inflatable wall defining a lumen therein. The inflatable wall may include an outer layer and an inner layer, and optionally an intermediate layer between the inner and layers. Intermediate layers may include one or more couplings between the outer and inner layers, and may include radial connectors extending between the outer layer and the inner layer.

An airway support device of the present disclosure can be attached to tracheal and/or bronchial cartilage on opposing sides of a tracheal and/or bronchial wall to pull the tracheal and/or bronchial cartilages toward each other to reconstruct and/or reshape to a normal anatomy across the membranous tracheal and/or bronchial wall and thus relieving tension across the tracheal and/or bronchial wall. The airway support device can include at least two longitudinal strips that extend longitudinally along and are attached (e.g., sutured) to the trachea and/or bronchus on opposite sides of the tracheal and/or bronchial wall. Lateral strips extending between the longitudinal strips can stretch across the tracheal and/or bronchial wall while under tension. The tracheal and/or bronchial wall can be attached (e.g., sutured) to the lateral strips to open the airway of the trachea and/or bronchus.

Systems and methods for deploying one or more stents within a bifurcated vessel are disclosed. A bifurcation-stent can include a main-branch portion and first and second side-branch portions each mechanically attached to the main-branch portion. The first and second side-branch portions are mechanically attached together at a branch point proximate the distal end of the main-branch portion. The bifurcation-stent can be disposed on two balloon catheters for deployment to a bifurcation. The bifurcation-stent is advanced within a main branch until it reaches the carina of the bifurcation, such as when the branch point abuts the carina. The bifurcation-stent can be deployed by inflating the balloon catheters such that the main-branch portion is disposed in the main vessel and the first and second side-branch portions are disposed in separate, respective side branches of the bifurcation.

A tubular construct that includes a braided tube embedded therein is disclosed herein. The braided tube may be embedded between layers of the tubular construct or may alternatively be positioned flush with the inside of the tubular construct. The tubular construct is resistant to kinking and has enhanced radial strength. The braided tube reinforces the wall of the tubular construct by improving burst pressure resistance, tube strength, and torque transmission. When radial pressure is applied to the braided tube that is embedded in the construct, the braided tube cannot expand lengthwise. Thus, the compression strength of the construct is increased in the radial direction. This feature takes advantage of the same principle used in the children's toy colloquially known as a Chinese finger trap. The increased radial strength of the tubular construct prevents the construct from collapsing and thereby enhances its structural integrity.

In a method for producing an implant from a biocompatible silicone, a 3D mathematical model of an implant to be produced is used to create a 3D model of a casting mold for the implant as a negative. The casting mold is produced from a polymeric material through an additive manufacturing process and coated through vapor deposition of a coating material from the parylene family at least in a region that comes into contact with the biocompatible silicone to be cast. A platinum-catalyzed 2-component thermosetting silicone as the biocompatible silicone for the implant is introduced into a mold cavity of the coated casting mold, with a residence time of the implant in a patient's body of more than 29 days. The casting mold is heated to vulcanize the biocompatible silicone, and after cooling down the vulcanized implant is demolded from the casting mold.

A medication delivery device for treatment of a pulmonary disorder in a patient includes an elongate member, an expandable member is coupled to a distal end of the elongate member, and an agent delivery portion coupled to an external surface of the expandable member. The agent delivery portion includes an agent that disrupts nerve activity.

Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.

An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers.

Devices for imparting vibration to implanted devices to reduce accumulation of biofilm thereon including a vibration tip, the vibration tip being sized and shaped to couple to a vibrator and receive a vibration therefrom, wherein the vibration tip is sized and shaped to conduct the vibration from the vibrator to an implanted device are disclosed. Methods of inhibiting biofilm formation including abutting a vibration source against an implanted device, and activating the vibration source to impart vibration to the implanted device thereby inhibiting a formation of biofilm on the implanted device are also disclosed.