A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes an outer frame and the seal is formed from a plurality of outwardly extending fibers.

A stent graft configured to facilitate the placement of a secondary stent is provided and a method thereof. The stent graft can include an elongated body with a frame structure, a lumen, and apertures at both ends of the elongated body. The frame structure can be covered by a graft material. At least one station can be located in the graft material. The at least one station has a perimeter defined by a ring structure connected to the graft material and an aperture bounded by the perimeter. The aperture can be covered by graft material. The at least one station can be fenestrated to facilitate placement of a secondary stent.

Described are stent grafts with at least on branch and mandrels used to form the stent grafts. Methods of making and using them are also described.

The invention relates to a medical device, the medical device comprising a balloon catheter, a first stent, and a second stent; the balloon catheter having a shaft and an inflatable balloon mounted to the shaft at the distal end the balloon having a distal portion having a first outer diameter and a proximal portion having a second outer diameter, wherein the first diameter is smaller than the second diameter and a transition region located between the distal portion and the proximal portion, a first stent having a first nominal diameter mounted on the distal portion of the balloon and a second stent having a second nominal diameter mounted on the proximal portion of the balloon, a distal portion of the second stent overlapping a proximal portion of the first stent, wherein the proximal end of the first stent is positioned proximal to the distal end of the second stent, the medical device further comprising a pre-cannulation means providing a passage from the interior of the second stent to the exterior of the first stent passing the stent overlapping portion between the inner surface of the second stent and the outer surface of the first stent.

A luminal stent has a tube body and a skirt surrounding the tube body. The skirt has a flexible connecting section and a stent graft connected to a proximal end of the flexible connecting section. A distal end of the flexible connecting section is sealed and connected to the outer surface of the tube body. A proximal end of the stent graft is suspended and provided with a first radial support structure. When the flexible connecting section is radially compressed, at least a part of the first radial support structure is bent towards a direction distant from the tube body. Also provided is a stent system including the luminal stent. The stent system and the luminal stent can prevent type III endoleaks.

Apparatus for progressively dilating the lumen of a narrow natural vessel such as an iliac artery and implanting a tubular device enabling access through the dilated lumen to conduct subsequent procedures via the dilated lumen, includes an inflatable integrated balloon locatable at least partially within the tubular device, the tubular device having a length L1 providing a self-expanding tubular body having at least a portion including stents, so that when the integrated balloon is removed the dilated lumen of the natural vessel remains dilated and supported by the tubular device.

The present disclosure relates to an endoluminal prosthesis, such as a stent graft that includes one or more fenestrations to accommodate endovascular disease, such as an aneurysm in cases where one or more side branches is involved. In one aspect, the prosthesis includes fenestrations that are pivotable to accommodate the dynamic geometry of the aortic branches.

An introduction arrangement for a fenestrated or branched stent graft (13) intended for deployment into the lumen of a vessel having a blind vessel extending from it. The introducer (1) has a distal end intended to remain outside a patient in use and a proximal end with a nose cone dilator (11) and an arrangement to retain the branched stent graft distally of the nose cone dilator. A sheath (15) on the introducer extends over the branched stent graft to the nose cone dilator. An indwelling catheter (21) extends from the distal end of the introducer and enters the fenestration or side arm and through to the nose cone dilator, the indwelling catheter has a guide wire (29) extending through it. The guide wire can be extended beyond the nose cone dilator in use before the sheath is withdrawn from the branched stent graft so that it can be snared from the contra-lateral artery.

A system for treating disease involving branching vessels of a mammal system can include a main graft assembly (i) having a lumen permitting fluid flow therethrough, and (ii) configured to expand within a first vessel of a mammal; and a branch graft assembly including a branch cover (i) having a cover lumen permitting fluid flow therethrough; and (ii) configured to expand within a branch vessel that branches from the first vessel. The branch graft assembly may also include an expandable branch stent extending within the cover lumen. The branch graft assembly may further include a branch sheath (i) extending between the branch stent and the cover lumen, and (ii) constraining radial expansion of the branch stent within the cover lumen.

A personalized prosthesis for implantation at a treatment site of a patient includes a self-expanding mesh or membrane having collapsed and expanded configurations. The collapsed configuration is adapted to be delivered to the treatment site, and the expanded configuration engages the personalized prosthesis with the treatment site. The mesh or membrane is personalized to match the treatment site in the expanded configuration, and has an outer surface that substantially matches the treatment site shape and size. The self-expanding mesh or membrane forms a central lumen configured to allow blood or other body fluids to flow therethrough. Methods of manufacturing and delivery of the personalized prosthesis are also disclosed.