A process and system for performing orthopedic surgery to create a series of channels with a subject's bone to allow a reduced pressure system to be applied directly to the bone-implant interface to enhance bone healing is provided. The process for to promote healing of a bone of a subject includes creating a three-dimensional model of the bone; preoperatively planning a location of an implant relative to the model; creating a plan for the location of precision channels that reach the bone-implant interface based on the model and the implant; resurfacing the bone to fit the implant into or onto the bone based on the preoperative plan; and milling the precision channels into the bone in the location to promote healing of the bone and/or bone implant interface; and applying a pressure reduction system at the bone-implant interface to promote bone healing.

A diagnostic system is provided that provides sensing and transmitting of fusion indicia to determine whether fusion has occurred. In some embodiments, a diagnostic system comprises a spinal implant or graft material; an antenna configured for sending signals to a remote location; a sensor configured for measuring at least one fusion indicia; and a receiver for receiving signals at the remote location.. In some embodiments, a method of utilizing a diagnostic system comprises the steps of inserting a spinal implant or graft material within a disc space between two vertebrae; measuring at least one fusion indicia; sending signals to a remote location with an antenna; and receiving signals with a receiver at the remote location.

A diagnostic system is provided that provides sensing and transmitting of fusion indicia to determine whether fusion has occurred. In some embodiments, a diagnostic system comprises a spinal implant or graft material; an antenna configured for sending signals to a remote location; a sensor configured for measuring at least one fusion indicia; and a receiver for receiving signals at the remote location. In some embodiments, a method of utilizing a diagnostic system comprises the steps of inserting a spinal implant or graft material within a disc space between two vertebrae; measuring at least one fusion indicia; sending signals to a remote location with an antenna; and receiving signals with a receiver at the remote location.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

A device and method for accelerating the conversion of oral bone graft to alveolar bone following extraction in a patient includes a vibrational dental device having a mouthpiece for contacting the dentition. Instructions are provided for using the vibrational dental device by placing the mouthpiece over the dentition, applying a vibratory force during a predetermined number of sessions throughout a predetermined treatment period, wherein the conversion of bone graft material to mature bone is enhanced and/or accelerated compared to without vibratory treatment.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

There is described a bone implant comprising at least one means for providing at least one bone stimulation dynamic interaction to at least one area of a bone-implant interface formed when the implant is inserted into bone, wherein the bone stimulation is one or more of bone growth, bone strengthening, bone densification and/or osseointegration between bone and the bone-implant interface.

The device is intended for the noninvasive induction of dynamic deformation of body tissue to differentiate tissue cells. It comprises the following components: (i) a suspension of particles suspended in solution; and (ii) an external actuator which is capable of magnetically, electrically, vibrationally, or thermally stimulating the suspended particles.

A multi-layer substrate apparatus includes a first layer configured to provide at least one electrical-based property. A second layer proximate to the first layer is configured to provide at least one mechanical-based property. A third proximate to the second layer includes at least one chemical component such that the third layer is enabled to regulate the multi-layer substrate apparatus based on a system that the multi-layer substrate apparatus is being used with. A fourth layer proximate to the third layer is configured to provide at least one magnetic-based property. A fifth layer proximate to the fourth layer is configured to provide support based on the system that the multi-layer substrate apparatus is being used with. The fifth layer includes a geometric portion that is configured to facilitate at least one process therein.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.