Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

A method for constructing a three-dimensional multi-scale surface to obtain controlled and improved physical and chemical configurations to promote the integration of orthopedic and/or dental implants, to human and/or animal tissues, in different shapes and geometries in a versatile manner, and can be applied to all types of metals, metal alloys and/or ceramic compounds. This method includes the modification at the macroscopic level of the roughness, with an objective of promoting the mechanical interlocking of the implant, followed by the modification of the surface for the formation of microtopography, then the microtopography is changed to obtain a nanotopography with characteristics that optimize cellular metabolic responses related to attraction, adhesion, spreading, proliferation and cell growth, in addition to phenotypic and genotypic inductions in undifferentiated cells and in osteoblast lineage, responsible for mineralization and bone neoformation. As a result, the interface between implant and bone is improved.

The invention relates to a joint implant for new tissue formation at a joint, the joint implant (1) comprising a pinlike body having a bottom region (11), a top region (12) and a shell region (13), wherein at least the top region (12), of the joint implant (1) has a hydrophobic surface for promoting chondroblastic differentiation of mesenchymal stem cells.

A biodegradable joint implant comprises a joint scaffold and a film layer coated on the surface of the joint scaffold. The joint scaffold comprises a first anchor fixing, a second fixing and a flexible spacer, and the first anchor fixing and the second anchor fixing are respectively axially connected to opposite sides of the flexible spacer. The joint implant is made of biodegradable material, and the film layer contains at least one substance that can induce tissue growth. A method for preparing the joint implant and a joint replacement method using the joint implant are also provided.

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

A device and a method of treatment for osteoarthritis of a joint, such as the hip. The implant is an extensible cap that is placed over the femoral head.

The invention relates to a joint implant for new tissue formation at a joint, wherein the joint implant (1) comprises a rod-shaped body with a base area (11), a cover area (12) and a sleeve area (13), wherein at least the cover area (12), in particular the entire rod-shaped body, of the joint implant (1) has a hydrophobic surface for facilitating chondrocyte differentiation of mesenchymal stem cells, and a thread structure (15) is at least partially formed on the sleeve area (13) of the joint implant (1).

A device and a method of treatment for osteoarthritis of a joint, such as the hip. The implant is an extensible cap that is placed over the femoral head.

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

The invention relates to a joint implant for new tissue formation at a joint, the joint implant (1) comprising a pinlike body having a bottom region (11), a top region (12) and a shell region (13), wherein at least the top region (12), of the joint implant (1) has a hydrophobic surface for promoting chondroblastic differentiation of mesenchymal stem cells.