Provided is a kit for treating tissue of a subject. The kit includes a tool for creating a wedge opening within a bone tissue, and an implant. In some examples, the kit also includes an introducer configured to deliver the implant into the wedge opening.

Provided herein are biomimetic osteochondral implants that are generally useful for the at least partial resurfacing of damaged cartilage within a joint. The implants are constructed to have a modular, layered structure in which the physical properties (e.g., stiffness and lubricity) or dimensions of each layer can be adjusted (e.g., by using the appropriate material and controlling the thickness thereof) based on the anatomy to be replaced. For example, the material and or thicknesses of the layers can be selected to approximate the physical properties and/or dimensions of cartilage (and, optionally, chondral and subchondral bone). Also provided herein are methods of treatment involving the use of said biomimetic osteochondral implants to repair an osteochondral defect in a joint.

A method for use of a double-structured tissue implant or a secondary scaffold stand-alone implant for treatment of tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A method of use of a stand-alone secondary scaffold implant or unit for treatment of tissue defects.

The present invention provides scaffolds comprising dual structural organization for bone and regeneration. Methods for fabricating and using the scaffold are also disclosed.

A special tube is disclosed for the insertion of materials inside the maxillary sinus in order to displace the Schneiderian membrane. The tube is connected to a source of a flowable material. The tube is inserted through the alveolar ridge beneath the maxillary sinus and when the flowable material is advanced through the tube the Schneiderian membrane is lifted. The tube can be part of a dental implant which is screwed inside the alveolar ridge.

Spinal implants are described that may be surgically implanted into the spine to replace damaged or diseased discs using a posterior approach. The implants are prosthetic devices that can approach or mimic the physiological motion and reaction of the natural disc. The implants are adapted to be used in minimally invasive surgical procedures.

An implant device used to replace and restore the function of the knee meniscus in a human. The compliant, yet resilient device is comprised of a biocompatible, non-degradable three-dimensional body comprised of at least a central body, a second structure, a third structure, and a coating. The device is concentrically aligned wherein the second structure is adjoined to the central body wherein the third structure is adjoined on the central body opposite of the second structure. The third structure further features a first and a second pulling element which is coupled to the central body and forms the outer periphery and major circumference of the device. The device is comprised of multiple components which provide tensile strength, compressive resilience, and attachment mechanisms for replacing the meniscus. Each structure is comprised of multiple surfaces which are further reinforced, separated, and connected by an individual plurality of vertical elements. The implantable device further features a surface coating on the surface of the central body.

A novel implant for replacing a portion of an articulation surface of a joint is disclosed. The implant includes a bone-engaging surface, a hydrogel portion forming an articulation surface opposite from the first bone-engaging surface, and a bone plate portion configured for securing the implant to a bone that forms the joint.

A tool configured to deliver a radially compressible hydrogel implant at a surgical site includes an introducer tube, a plunger provided inside the introducer tube and configured to travel from the proximal end of the introducer tube toward the distal end of the introducer tube urging the hydrogel implant through a sloped portion of the introducer tube radially compressing the implant before exiting through the distal end of the introducer tube, a handle connected to the introducer tube, and a clamp hingeably connected to the handle.

An implant system includes a first portion, a second portion, and a third portion. The first portion includes a hydrogel; the second portion includes a porous material and the hydrogel in pores of the porous material; and the third portion includes the porous material. The first portion is free of the porous material and the third portion is free of the hydrogel. The third portion has non-uniform lateral cross-section.