Methods and devices are provided for delivering and affixing tissue replacements. In one embodiment, a tissue scaffold can be delivered into a patient through a cannula to a cavity formed at a defect site in tissue, e.g., cartilage. A delivery shaft can be used to deliver the scaffold through the cannula, and a loading device can help load the scaffold onto the delivery shaft. A delivery guide device can position and temporarily hold the scaffold within the cavity. The delivery guide device can guide one or more surgical instruments to the scaffold to affix the scaffold within the cavity, e.g., to bone underlying the scaffold, using at least one securing mechanism.

An implantable acellular polymeric scaffold device functionalized with aggrecan is provided. Also provided are methods of fabricating a polymeric scaffold device, including methods of fabricating the scaffold device via 3D printing. Methods of treating a cartilage defect in a subject in need thereof comprise application of the disclosed scaffold device in combination with microfracture procedures. A specialized lid for a centrifugation well plate is also provided.

An implant for repairing an articular cartilage defect site including an implant fixation portion with an upper segment and at least one bone interfacing segment and a top articulating portion with an articulating surface and an engagement surface. The upper segment includes a supporting plate with a first locking mechanism segment. The engagement surface includes a second locking mechanism segment. The first locking mechanism segment with at least two channels is structured to couple to the second locking mechanism segment with at least two protrusions. The at least one bone interfacing segment structured for insertion into the articular cartilage defect site. An implant including an implant fixation portion, a top articulating portion, and a locking mechanism with a first locking segment coupled to the upper segment and a second locking segment coupled to the at least one engagement surface and structured to couple to the first locking segment.

Artificial meniscal scaffolds characterized by a composite of circumferential polymer fiber network and orthogonal polymer fiber network embedded in an arcuate bioresorbable matrix comprised of collagen and hyaluronic acid. The orthogonal polymer fiber network prevents separation of the circumferential polymer fiber networks. The polymer fiber networks convert axial compressive forces on the scaffolds to tensile loads on the circumferential polymer fibers. The composite scaffold can be anchored to bone by novel anchoring components that protect the polymer fibers and ensure immediate securement of the artificial meniscal scaffold to bone.

A system for harvesting bone material from a bone may include a rotary cutter defining a rotary cutter longitudinal axis extending between a rotary cutter proximal end and a rotary cutter distal end. The rotary cutter may have a drive shaft configured to receive input torque, and an osteochondral cutter configured to cut the tissue and receive the tissue material in response to rotation of the osteochondral cutter under pressure against the tissue. The system may further include a bone port defining a bone port longitudinal axis extending between a bone port proximal end and a bone port distal end. The bone port may have a bone port cannulation sized to closely fit over the osteochondral cutter. At least one of the bone port proximal end and the bone port distal end may be securable to the tissue. A stratiform tissue graft may be delivered through the bone port.

Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.

A meniscus replacement device for replacing damaged soft tissue at a host knee includes a first component comprising a first tissue-interface surface shaped to free-floatingly interface with tissue structure of one of a femur and a tibia in a knee joint having a damaged soft tissue, and comprises a second component comprising a second tissue-interface surface shaped to free-floatingly interface with a second tissue structure of the other of the femur and the tibia in the knee joint. The second component may include a containment cavity receiving at least a portion of the first component. In another form, the free floating soft joint tissue replacement component and the base component are fixed together. In some aspects, the second tissue-interface surface is shaped to fit contours of a natural tibia plateau. In some aspects, the first tissue-interface surface is shaped to fit contours of a femoral surface.

The three-dimensional lattice structures disclosed herein have applications including use in medical implants, Some examples of the lattice structure are structural in that they can be used to provide structural support or mechanical spacing In some examples, the lattice can be configured as a scaffold to support bone or tissue growth Some examples can use a repeating modified rhombic dodecahedron or radial dodeca-rhombus unit cell. The lattice structures are also capable of providing a lattice structure with anisotropic properties to better suit the lattice for its intended purpose.

The invention relates to a joint implant for new tissue formation at a joint, the joint implant (1) comprising a pinlike body having a bottom region (11), a top region (12) and a shell region (13), wherein at least the top region (12), of the joint implant (1) has a hydrophobic surface for promoting chondroblastic differentiation of mesenchymal stem cells.

Compositions and methods for making biocompatible articles are provided. A method includes preparing a 3D printable mixture and depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article. The predetermined pattern has a porosity suitable for a bone or cartilage scaffold. Associated 3D printable compositions and porous articles made from the described methods are also described. The preparing a 3D printable mixture can comprise conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, or providing a mixture that comprises a ceramic material and a binder, and wherein the 3D printable mixture comprises from 50 wt. % to 80 wt. % of the ceramic material.