Glenoid components with asymmetric fixation points are provided. Also, methods and devices are provided for the optimization of shoulder arthroplasty component design through the use of medical imaging data, such as computed tomography scan data. The methodology may improve the understanding of glenoid anatomy through the use of medical imaging data and 3D modeling, and for glenoid components that exploit this methodology. The methodology provides for how anatomical features change based on the specific location in the glenoid. The methodology can optimize loading and fit at the bone-device interface. Asymmetrical glenoid components are provided with significantly improved initial fixation.