The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.

The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.

The present invention relates to a tissue-engineered intervertebral disc (IVD) comprising a nucleus pulposus structure comprising a first population of living cells and an annulus fibrosis structure surrounding and in contact with the nucleus pulposus structure, the annulus fibrosis structure comprising a second population of living cells and collagen.

Intersomatic cage for vertebral stabilization, including a generally prismatic body consisting of surface receptacles containing slow prolonged release substances selected from the classes of anti-inflammatory, anti-infection and bone regrowth promoter drugs. The receptacles are in the form of gratings of grooves.

A method for growing a channeled spinal implant in situ, using a surgical additive-manufacturing system having a dispensing component, and implants formed thereby. The method can include positioning the dispensing component at least partially within an interbody space, between a first patient vertebra and a second patient vertebra, and maneuvering, in an applying step, the dispensing component within the interbody space and depositing, by the dispensing component, printing material on or adjacent the first vertebra. The applying step includes maneuvering the dispensing component and applying the printing material selectively to form an outer surface of the implant having a channel opening and to form an interior of the implant having at least one elongate channel extending to the opening.

A spinal implant includes a body having an inner surface and a connecting wall. The inner surface defines at least one cavity and the connecting wall is disposed about the at least one cavity. The connecting wall defines at least one opening. An agent is disposable with the at least one cavity. Spinal constructs, surgical instruments, systems and methods are disclosed.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

Additive-manufacturing systems for forming non-woven fibrous implants are disclosed. Additive-manufacturing systems may include a robotic subsystem having scanning and imaging equipment configured to scan a patient's anatomy, and an armature including at least one dispensing nozzle configured to selectively dispense at least one material. The system may further include a controller apparatus configured to send a control signal to control the scanning and imaging equipment to determine a target alignment of a patient's spine, and develop an additive-manufactured printing plan including an additive-manufactured material selection plan based on the target alignment of the patient's spine. The controller may execute the additive-manufactured printing plan to: dispense the at least one material to form a non-woven fibrous component. The non-woven fibrous component may define a plurality of randomly oriented fibers further defining a plurality of open pore spaces between adjacent fibers configured to facilitate boney ingrowth between adjacent fibers.

A cage device for harvesting bone graft material for use in bone fusion surgery, e.g., a spinal fusion. The device has a chamber configured to contain a slurry of morselized bone and blood that effuses from adjacent bones when the device is placed in a space between the bones, and a bone cutter assembly is inserted into the chamber and operated. In one embodiment, the cutter assembly includes an elongated cannula having a bend at a distal end, and a wire arranged to slide inside the cannula so that a cutting tip of the wire can be set to project a desired distance from the distal end. When the cannula is driven to rotate about its long axis, the wire cutting tip strikes and cuts grooves in the facing surfaces of the bones to produce the mentioned slurry which remains inside the chamber to promote a solid and healthy fusion.