An endorectal cooling device (ECD) includes an elongated body, a cooling fluid circuit, and a gas bubble removal device. The elongated body includes an insertable portion for insertion into a patient's rectum and an external portion that remains external to the rectum. The cooling fluid circuit is defined in the elongated body from the external portion to the insertable portion and circulates cooling fluid to regulate a temperature of a cooling surface on the insertable portion. The gas bubble removal device can include a coil, a tube, a mesh, and/or a hole that is disposed on or defined in the insertable portion of the elongated body, such as the cooling surface. A low-pressure source, such as a vacuum pump or a Venturi structure, can be fluidly coupled to the gas bubble removal device to remove fluid and bubbles by a suction force after the ECD is inserted into the rectum.

A neck fan includes an arc-shaped shell configured to hang around user's neck and at least four fan assemblies arranged in the shell. The shell includes a first part and a second part. Each of the first part and the second part defines an accommodating space, air inlets and air outlets communicated with the accommodating space, at least one partition is arranged in the accommodating space and configured to divide the accommodating space into at least two accommodating parts arranged along an extension direction of the shell. Each of the fan assemblies is arranged in one of the at least two accommodating parts and is configured to direct air into the one of the at least two accommodating parts through corresponding air inlets and to direct air out of the one of the at least two accommodating parts through corresponding air outlets.

A device for enhancement of visual appearance including a first applicator to be coupled to a first area of a body region, with a first magnetic field generating device and a first radiofrequency electrode, a second applicator to be coupled to a second area of the body region, with a second magnetic field generating device. The device further includes a first energy storage device, a second energy storage device, and a first switching device to discharge energy from the first energy storage device to the first magnetic field generating to generate a first time-varying magnetic field to cause muscle contraction, and a second switching to discharge energy from the second energy storage device to the second magnetic field generating device to generate a second time-varying magnetic field. The first radiofrequency electrode may provide first radiofrequency waves causing heating of tissue within the first area of the body region.

The present invention relates to a visibility increase method for a cryochamber comprises pre-chamber equipped with air-drying system and heat exchanger ice removal system. The cryochamber can include an air dryer with at least one air dryer unit of any kind, and inlet and outlet ducts, which connect air dryer and pre-chamber. Both inlet and outlet of the air dryer are connected to the pre-chamber. Ice removal system can include at least one a pressurized gas source and for example an air knife, nozzle or orifice. Both systems improve user's field of view inside cryochamber, which greatly increases comfort of the user and for ice removal system, it additionally improves efficiency of the cryochamber.

Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.

A neck fan includes an arc-shaped housing configured to hang around user's neck and at least four fan assemblies arranged in the housing. The housing includes a first part and a second part. Each of the first part and the second part defines an accommodating space, air inlets and air outlets communicated with the accommodating space, at least one partition is arranged in the accommodating space and configured to divide the accommodating space into at least two accommodating parts arranged along an extension direction of the housing. Each of the fan assemblies is arranged in one of the at least two accommodating parts and is configured to direct air into the one of the at least two accommodating parts through corresponding air inlets and to direct air out of the one of the at least two accommodating parts through corresponding air outlets.

A method of performing photodynamic therapy is provided. The method includes applying, to the skin of a patient, a topical composition. The topical composition includes 5-aminolevulinic acid (ALA) hydrochloride, and a vehicle comprising at least one chelating agent to enhance accumulation of protoporphyrin IX (PpIX) in the skin. The method further includes incubating the topical composition, and following incubation, applying, to the skin, heat from a heat source for at least a first time period.

A method and apparatus for manipulating a temperature set-point of a human or homeothermic-animal for increasing or decreasing the body temperature above or below the prevailing body temperature for therapeutic purposes. The method includes the steps of warming or cooling sphenoid sinuses externally resulting in manipulation of the temperature of the pituitary gland which in turn results in manipulation of the body-temperature set-point and the body temperature manipulates accordingly to the new temperature set-point. A heat exchange medium can be used to warm or cool sphenoid sinuses and thus the pituitary gland. The heat exchange fluid can be liquid, or gas maintained at a predetermined temperature. Alternatively, a temperature-controlled probe can be used that upon contact with the sphenoid sinuses provides for the heat exchange.

At least some aspects of the present disclosure feature a convective system including an inflatable convective device and a manifold. The inflatable convective device has a pneumatic structure and two openings into the pneumatic structure. The hose manifold includes a hose connector configured to connect to a hose, two outlet connectors configured to connect to the two openings respectively, where the hose connector and the two output connectors are in fluid connection.

The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.