Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

Augmented wound dressing systems may include traditional wound dressing components and one or more sensor devices such as accelerometers, humidity monitors, temperature monitors, electrocardiography leads, and/or oximetry sensors. Measurements from the sensor devices may be used to monitor one or more aspects of patient and/or wound health. In addition, or alternatively, one or more images of a wound that may be taken over time may be analyzed and/or compared with one another to determine one or more characteristics of the wound in order to, for example, assess wound health/healing and determine whether an intervention is necessary to assist with wound healing.

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing that includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen. The matrix is at least partially permeable to the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The metallated porphyrin can be prepared from a phosphorescent meso-unsubstituted porphyrin having the Formula (I): ##STR00001##
wherein M is a metal, wherein each R is independently an atom or a group of atoms, and wherein at least one R is —O(C)OR′, wherein R′ is optionally substituted alkyl.

A non-invasive tissue oxygenation system for accelerating the healing of damaged tissue and to promote tissue viability is disclosed herein. The system is comprised of a lightweight portable electrochemical oxygen concentrator, a power management system, microprocessors, memory, a pressure sensing system, an optional temperature monitoring system, oxygen flow rate/oxygen partial pressure monitoring and control system, a display screen and key pad navigation controls as a means of providing continuous variably controlled low dosages of oxygen to a wound site and monitoring the healing process. A kink resistant oxygen delivery tubing, whereby the proximal end is removably connected to the device and the distal end with holes or a flexible, flat, oxygen-permeable tape is positioned at or near the wound bed as a means of applying near 100% pure oxygen to the wound site. The distal end of the tube is in communication with the electrochemical oxygen concentrator and wound monitoring system to communicate oxygen partial pressure and, where appropriate, temperature information. A moisture absorbent dressing is positioned over the distal end of the tubing at the wound site and a reduced moisture vapor permeable dressing system is positioned whereby covering the moisture absorbent dressing, distal end of tubing and wound site creating a restricted or occluded airflow enclosure. The restricted airflow enclosure allows the out-of-the-way control and display unit to provide a controlled hyperoxia and hypoxia wound site for accelerated wound healing.

Various devices and methods useful for providing vasocompression to a patient who is undergoing chemotherapy treatment.

In some embodiments, a wound dressing that incorporates a number of sensors or sensors separate from the wound dressing can be utilized in order to monitor characteristics of a wound as it heals or to identify one or more risk factors or conditions that may precipitate a wound. In some implementations, a wound dressing configured to be positioned in contact with a wound includes a substantially flexible substrate supporting one or more sensors. The one or more sensors can include temperature sensors, conductivity sensors, multispectral optical measurements sensors, pH sensors, pressure sensors, colorimetric sensors, optical sensors, ultraviolet (UV) sensors, or infrared (IR) sensors.

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

A wound monitoring and/or therapy apparatus can include multiple sensor circuits, a selection circuit coupled to each sensor circuit, and a processor configured to be in communication with the selection circuit. Each sensor circuit can process multiple sensor signals to generate a single output signal from the multiple sensor signals. Each of the sensor signals can correspond to a measurement of a sensor positioned on a substrate that is configured to be positioned at least partially in a wound. The selection circuit can receive the single output signals from the sensor circuits and outputs a selected single output signal. The processor can receive the selected single output signal and decomposes the selected signal output signal into the multiple sensor signals used to generate the selected single output signal. The processor can activate sensors and receive sensor data from the sensors. The processor can digitize the sensor data and transmit the digitized sensor data to a remote controller.

Systems, methods, and apparatus are provided for detecting leaks in systems for treating a patient with reduced pressure. In one instance, a system includes a distribution manifold for disposing proximate to the tissue site and a sealing member for disposing over the distribution manifold and at least a portion of intact epidermis of the patient. The sealing member has at least a portion that is substantially transparent. The system further includes a reduced-pressure source associated with the distribution manifold for providing reduced pressure to the distribution manifold and a leak-detection member sized and configured to substantially surround the distribution manifold. The leak-detection member includes a detection material that develops a color contrast when a portion is exposed to air and a portion is not exposed to air. The leak detection member works with even low flow systems. Other systems, methods, and apparatus are presented.

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.