During a medical procedure, a transseptal fenestration is made at a septum of the heart and a shunt is implanted into the transseptal fenestration. During the same medical procedure, a transapical puncture is made into a left ventricle of the heart. A prosthetic valve is delivered via the transapical puncture and implanted at a mitral valve of the heart. Subsequently to delivering the prosthetic valve and making the transseptal fenestration, the transapical puncture is closed. Other embodiments are also described.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes an outer frame and the seal is formed from a plurality of outwardly extending fibers.

An endoprosthesis having a length, a first end, a second end, and a longitudinal axis is disclosed herein, where the endoprosthesis is expandable from a compact, delivery configuration to an enlarged, deployed configuration. The endoprosthesis includes a plurality of rows of stent elements along the length of the endoprosthesis, where the plurality of rows include a first row and a second row located adjacent to the first row. The first row of stent elements has a first plurality of alternating apices, and the second row of stent elements has a second plurality of alternating apices. The first and second pluralities of alternating apices define a spaced apart, interlocking arrangement. The endoprosthesis also includes a discontinuous web of material comprising a plurality of web elements spaced from one another and interconnecting the first and second pluralities of alternating apices. The plurality of web elements are arranged along a first, common circumference such that the plurality of web elements restrict torsion and axial compression of the endoprosthesis between the first and second rows of stent elements when the endoprosthesis is in the enlarged, deployed configuration.

A prosthetic liner for application on a stump, the prosthetic liner including an elastic base, which has a proximal opening for insertion of the stump a receiving space, and a distal end. At least one pneumatic piston is arranged on the outer face of the prosthetic liner.

A prosthetic implant with improved properties, suitable for implantation to the human body, comprising a composite comprising a base material and a plurality of additives, wherein the additives are selected from radiolucent additives and/or hyperechoic additives; or wherein the additives are selected to reduce the solvent concentration by between 5%-95%; or wherein the additives are selected to increase the elastic modulus by more than 20%; or wherein the additives are selected for combining these effects.

A medical device may include an implantable device for treating a body tissue structure. The implantable device may include a wire structure which may include a wave pattern. The wire structure may be elastic so as to provide a pressure around the body tissue structure such that the pressure may change with movement of the body tissue structure.

A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

A valve prosthesis and methods for implanting the prosthesis are provided. The prosthesis generally includes a self-expanding frame and two or more engagement arms. A valve prosthesis is sutured to the self-expanding frame. Each engagement arm corresponds to a native mitral valve leaflet. At least one engagement arm immobilizes the native leaflets, and holds the native leaflets close to the main frame. The prosthetic mitral valve frame also includes two or more anchor attachment points. Each anchor attachment point is attached to one or more anchors that help attach the valve prosthesis to the heart.

A hybrid prosthetic heart valve configured to replace a native heart valve and having a support frame configured to be expanded post implant in order to receive and/or support an expandable prosthetic heart valve therein (a valve-in-valve procedure). The prosthetic heart valve may be configured to have a generally rigid and/or expansion-resistant configuration when initially implanted to replace a native valve (or other prosthetic heart valve), but to assume a generally expanded form when subjected to an outward force such as that provided by a dilation balloon or other mechanical expander. An inflow stent frame is expandable for anchoring the valve in place, and may have an outflow end that is collapsible for delivery and expandable post-implant to facilitate a valve-in-valve procedure.

A compliant scaffold incorporates a plurality of elongated apertures that form a geometric pattern enabling biaxial expansion or contraction. An elongated aperture has a pair of nodes located on opposing sides of the aperture and between a pair of antinodes located on the extended and opposing ends of the elongated aperture. A geometric pattern may have various geometric shapes, or tiles, between the plurality of apertures. The geometric tiles have a bounded perimeter formed by the plurality of elongated apertures. A substantial portion of the elongated apertures may be configured with the antinodes proximal to one of said pair of nodes of a separate elongated aperture; wherein the antinodes are closer to one of the pair of nodes than to any other antinode. This unique arrangement of the elongated apertures may be formed in biological material in vivo or ex vivo.