An aortic arch graft includes a generally cylindrical member formed from a plurality of struts having a proximal end and a distal end and a longitudinally extending lumen. The proximal end is configured for deployment within the ascending aorta and the distal end configured for deployment in the descending thoracic aorta. The aortic arch graft includes a graft material having an opening disposed between the proximal end and distal end with a plurality of radiopaque markers disposed around a periphery of the opening. The opening within the graft material allows blood flow transverse to the longitudinal lumen of the generally cylindrical member.

A gastroesophageal reflux preventer and related methods are provided. A gastroesophageal reflux preventer is configured to be positioned around the exterior of a body organ and may include an elongate portion including a plurality of nodes positioned along at least a portion of the length of the elongate portion.

A ringless web is configured to repair heart valve function in patients suffering from degenerative mitral valve regurgitation (DMR) or functional mitral valve regurgitation (FMR). In accordance with various embodiments, a ringless web can be anchored at one or more locations below the valve plane in the ventricle, such as at a papillary muscle, and one or more locations above the valve plane, such as in the valve annulus. A tensioning mechanism connecting the ringless web to one or more of the anchors can be used to adjust a tension of the web such that web restrains the leaflet to prevent prolapse by restricting leaflet motion to the coaptation zone and/or promotes natural coaptation of the valve leaflets.

Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

A ringless web is configured to repair heart valve function in patients suffering from degenerative mitral valve regurgitation (DMR) or functional mitral valve regurgitation (FMR). In accordance with various embodiments, a ringless web can be anchored at one or more locations below the valve plane in the ventricle, such as at a papillary muscle, and one or more locations above the valve plane, such as in the valve annulus. A tensioning mechanism connecting the ringless web to one or more of the anchors can be used to adjust a tension of the web such that web restrains the leaflet to prevent prolapse by restricting leaflet motion to the coaptation zone and/or promotes natural coaptation of the valve leaflets.

An improved gastroesophageal reflux preventer and related methods are provided. The improved gastroesophageal reflux preventer may include an absorbable material able to be placed in contact with a body organ and configured to induce a scarification of the body organ in response to absorption by the body organ of the material. In this manner, a proximate sphincter may be tightened, such as to ameliorate reflux through a gastroesophageal sphincter.

A prosthetic valve including a leaflet frame configured to be transitioned from a collapsed state having a first diameter to an expanded state having a second diameter that is larger than the first diameter. The leaflet frame has an inlet and outlet end and defining a longitudinal axis. The leaflet frame includes a plurality of frame members that form a framework defining plurality of cells each having an interior cell space, the plurality of cells including an attachment cell. The plurality of frame members includes a plurality of sub-cell attachment members extending into the interior cell space of the attachment cell, the sub-cell attachment members each being configured to define a plurality of attachment locations along a sub-cell attachment line defined within a plane that intersects with the longitudinal axis such that the sub-cell attachment line extends through the interior cell space of the at least one attachment cell.

Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

A method for controlling intraocular pressure in a patient’s eye is provided. The method includes creating an intraocular entry into the eye, selecting a location along an optical disc of the eye, creating a conduit connecting at least a portion of an intravitreal cavity with at least a portion of a subarachnoid space in the eye at the selected location, deploying at least one stent communicating between the intravitreal cavity and the subarachnoid space via the conduit, and equilibrating the intraocular pressure in the eye by allowing the stent to communicate fluid flow between the intraocular compartment and the subarachnoid space.

A system for spinal surgery includes a prosthesis comprising a plurality of bone anchors which engage an intervertebral construct for fusion or motion preservation. The fusion construct comprises a spacer optionally encircled by a jacket. The motion preservation construct may comprise an articulating disc assembly or an elastomeric disc assembly. Any of the constructs may occupy the intervertebral disc space between adjacent vertebrae after removal of an intervertebral disc. The anchors slidingly engage the construct to securely fix the prosthesis to the vertebrae. The anchors and jacket of the fusion construct provide a continuous load path across opposite sides of the prosthesis so as to resist antagonistic motions of the spine.