An intracranial prosthesis comprised of a flat body having an interior ultrasound-compatible window and a ring having a plurality of access ports about the outer portion capable of engaging a plurality of diagnostic instruments and/or intracranial delivery systems so that a practicing medical professional can monitor certain parameters of a patient or deliver therapeutic agents to the patient while using an ultrasound-monitoring device to image the patient's brain. The prosthesis is designed to allow for the continuous, uninterrupted, simultaneous monitoring of a number of parameters of a patient's brain at the patient's bedside.

An ultrasonic device having a tri-axial configuration including an ultrasound transmission member, a dilator, and a sheath is disclosed. The ultrasound device may be used in a procedure to treat an occluded blood vessel. The ultrasound transmission member can transmit ultrasonic energy from an ultrasonic transmission member into the subintimal space of a blood vessel. The sheath may articulate to aid in the process of re-entering the central lumen of the blood vessel.

An intracranial prosthesis comprised of a flat body having an interior ultrasound-compatible window and means about the outer portion capable of engaging a plurality of diagnostic instruments and/or intracranial delivery systems so that a practicing medical professional can monitor certain parameters of a patient or deliver therapeutic agents to the patient while using an ultrasound-monitoring device to image the patient's brain. The prosthesis is designed to allow for the continuous, uninterrupted, simultaneous monitoring of a number of parameters of a patient's brain at the patient's bedside.

A system for transluminal delivery of cardiac repair components into a heart includes a visualization catheter having an imaging device disposed at a distal end. An anchor lumen extends through the visualization catheter to an anchor port disposed on its distal wall. An adjustment mechanism is translatably disposed within the visualization catheter and configured to adjust a height of the anchor port relative to a septum of the heart. The imaging device may be used to visualize the placement of anchors expelled from the port into a tissue target. The adjustment mechanism enables accurate placement of multiple anchors along a consistent axis within the heart by rotating the visualization catheter to align the port with different tissue targets. The anchors may be coupled to sutures and the tissue targets may include papillary muscles that are reconfigured by pulling together and securing the sutures to approximate a healthy papillary structure.

Methods, apparatuses and systems are described for deploying a stent into a body lumen. A stent delivery system may include a sheath with a partially-tubular first portion made from a first material and a second portion made from a second material that is adhered to the first portion to form a tubular body. In some cases, the first material may be chemically incompatible with the second material such that the adhesion between the first portion and second portion is free from cross-linked bonds. The stent delivery system may further include a guidewire lumen with a distal tip that may be slidably disposed within the sheath and a tubular stent disposed between the guidewire lumen and an inside surface of the sheath. The sheath may be formed by coextruding the first material and the second material to form a striped tubular body of the sheath.

An intracranial prosthesis comprised of a flat body having an interior ultrasound-compatible window and means about the outer portion capable of engaging a plurality of diagnostic instruments and/or intracranial delivery systems so that a practicing medical professional can monitor certain parameters of a patient or deliver therapeutic agents to the patient while using an ultrasound-monitoring device to image the patient's brain. The prosthesis is designed to allow for the continuous, uninterrupted, simultaneous monitoring of a number of parameters of a patient's brain at the patient's bedside.

A hand-held device for home use is disclosed for cleaning eyelids, eye margins and eye lashes. The device includes a housing, which forms a handle, and a cleaning head, attached on one end. In accordance with an important aspect of the invention, a vibration generator is used to drive the cleaning head sonically. The sonically driven cleaning head is placed in contact with one or both eye lids for each eye and either held in a stationary position or moved from side to side or back and forth. The vibration of the cleaning head in contact with the soap and effectively scrubs the upper eyelid or lower eyelid without the need for vigorous scrubbing or significant agility. The vibrating cleaning head is a more effective daily home cleaning tool for eyelids and eyelashes than known devices with rotary swabs or sponges.

Methods, apparatuses and systems are described for deploying a stent into a body lumen. A stent delivery system may include a sheath with a partially-tubular first portion made from a first material and a second portion made from a second material that is adhered to the first portion to form a tubular body. In some cases, the first material may be chemically incompatible with the second material such that the adhesion between the first portion and second portion is free from cross-linked bonds. The stent delivery system may further include a guidewire lumen with a distal tip that may be slidably disposed within the sheath and a tubular stent disposed between the guidewire lumen and an inside surface of the sheath. The sheath may be formed by coextruding the first material and the second material to form a striped tubular body of the sheath.

A drug applicator for a system for ultrasound-enhanced delivery of at least one drug to a target site in a intraocular space, the system comprising a signal generating unit operationally connected to an ultrasound transducer, wherein the drug applicator comprises at least one space hold the drug, is made from a low ultrasound attenuation material, is configured to provide low ultrasound loss coupling of the system to the sclera, and is configured to be mechanically coupled to the system and further configured to be coupled to the ultrasound transducer with low ultrasound loss. The signal generating unit and/or the ultrasound transducer are configured to emit an ultrasound wave form in at least one application cycle, the application cycle comprising at least one ultrasound emitting event with a time duration TA and a waiting period with a time duration TW.

A hand-held device for home use is disclosed for cleaning eyelids, eye margins and eye lashes. The device includes a housing, which forms a handle, and a cleaning head, attached on one end. In accordance with an important aspect of the invention, a vibration generator is used to drive the cleaning head sonically. The sonically driven cleaning head is placed in contact with one or both eye lids for each eye and either held in a stationary position or moved from side to side or back and forth. The vibration of the cleaning head in contact with the soap and effectively scrubs the upper eyelid or lower eyelid without the need for vigorous scrubbing or significant agility. The vibrating cleaning head is a more effective daily home cleaning tool for eyelids and eyelashes than known devices with rotary swabs or sponges.