In a method and system for producing an implant, the latter is designed with one or more surfaces extending in the longitudinal direction of the implant. Two or three production stages can be used. In one stage, either a topography with a long wave pattern is produced by means of cutting work, or laser bombardment or further cutting work is used to produce a topography with an intermediate-length wave pattern. In addition, an oxidation process or shot-peening or etching is used to produce an outer layer. When using two of said production stages, said cutting work or said laser bombardment or further cutting work is followed by the oxidation process or the shot-peening or etching method. When using all three production stages, cutting work is followed by laser bombardment, or further cutting work, which in turn is followed for example by the oxidation process. The invention also relates to an implant which is produced using the method and is identified, ordered and produced using the system. The invention permits effective treatment of different implant situations.

Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

An orthopaedic implant can replace a joint in a patient. The orthopaedic implant includes a first component having a first component surface and a second component having a second component surface. The first component surface and the second component surface mate at an interface. The first component surface includes a metal substrate, a nanotextured surface, a ceramic coating, and a transition zone. The nanotextured surface is disposed directly upon the metal substrate and has surface features in a size of 10.sup.−9 meters. The ceramic coating conforms to the nanotextured surface and includes a plurality of bio-active sites configured to attract and retain calcium and phosphorous cations. The transition zone is disposed between the metal substrate and the ceramic coating. The transition zone includes a concentration gradient transitioning from the metal substrate to the ceramic coating and there is no distinct interface between the metal substrate and the ceramic coating.

An implant can be implantable into a human body and can include a metallic substrate and a ceramic layer. The metallic substrate can be formed by additive manufacturing. The metallic substrate can be engageable with a bone. The metallic substrate can include an inner surface, an outer surface, and a plurality of retention features. The inner surface can define a plurality of pores configured to promote bone ingrowth into the metallic substrate. The plurality of retention features can include a proximal portion connected to the outer surface and the proximal portion can define a proximal width. The ceramic layer can be a bearing surface that can be spray coated to the metallic substrate and formed around the retention features to interlock the ceramic layer with the metallic substrate.

A femoral head arthroplasty system can comprise a femoral prosthesis comprising a mounting plate having a first side and an opposed second side. An adapter can extend from the second side of the mounting plate. An implant body can extend from the first side of the mounting plate. The implant body can extend from the mounting plate by a distance no greater than 90 mm. The femoral head arthroplasty system can further comprise a femoral head replacement having a generally spherical surface and comprising a recess that is shaped to complementarily receive the adapter of the femoral prosthesis.

An implant includes a substrate and a coating. The substrate includes a first outer surface. The coating is disposed on the first outer surface. The coating includes eighty percent titanium dioxide and twenty percent aluminum oxide.

The present invention addresses a problem of providing a three-dimensional structure having bioactivity in which a coating film includes a titanium alkoxide hydrolysis product is coated with high adhesion strength on the surface of a three-dimensional structure main body, and also providing a method for producing such three-dimensional structure. The three-dimensional structure having bioactivity includes a three-dimensional structure main body having a concave section and/or a convex section on a surface, and having a coating film on the surface of the three-dimensional structure main body, and the coating film that includes a titanium alkoxide hydrolysis product a thickness of 10 nm to 200 nm. No cracks or peelings of the coating film can be recognized when the surface of the three-dimensional structure is observed with a scanning electron microscope at a magnification of 300, and the coating film has bioactivity when evaluated under conditions specified in ISO 23317.

A femoral head arthroplasty system can comprise a femoral prosthesis comprising a mounting plate having a first side and an opposed second side. An adapter can extend from the second side of the mounting plate. An implant body can extend from the first side of the mounting plate. The implant body can extend from the mounting plate by a distance no greater than 90 mm. The femoral head arthroplasty system can further comprise a femoral head replacement having a generally spherical surface and comprising a recess that is shaped to complementarily receive the adapter of the femoral prosthesis.

A medical device is provided comprising an at least one surface deposited with at least a first conformal coating and a second conformal coating deposited on the first conformal coating, wherein the first conformal coating comprises the first chemical substance and the second conformal coating comprises the second chemical substance. In some instances, the first coating is deposited over the first chemical substance and the second coating is deposited over the second chemical substance.