Assemblies, systems, kits, and methods related to an endoprosthetic rotating hinge assembly. The exemplary embodiments disclosed herein can comprise a preassembled rotating hinge subassembly having a hingedly rotating femur box configured to be mechanically engaged to a femoral component via a femur fastening mechanism, the femur fastening mechanism being non-axially aligned with a tibial axis of rotation when the knee is in flexion or extension.

An artificial joint cup (2), in particular a hip joint cup, for implanting in a cavity in a bone. The joint cup (2) is, in particular, substantially in the form of a spherical dome cup, having a convex outer surface (3) and a concave inner surface (4). In addition, the joint cup (2) comprises an outer diameter (OD) and an inner diameter (ID). The ratio of the difference (D) between the outer diameter (OD) and the inner diameter (ID) in relation to the outer diameter (OD) is in a region between 0.5 and 0.07, preferably between 0.3 and 0.075, particularly preferably between 0.2 and 0.1. The joint cup (2) is manufactured from a ceramic material, and the convex outer surface (3) has a micro-structuring.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

An orthopaedic implant can replace a joint in a patient. The orthopaedic implant includes a first component having a first component surface and a second component having a second component surface. The first component surface and the second component surface mate at an interface. The first component surface includes a metal substrate, a nanotextured surface, a ceramic coating, and a transition zone. The nanotextured surface is disposed directly upon the metal substrate and has surface features in a size of 10.sup.−9 meters. The ceramic coating conforms to the nanotextured surface and includes a plurality of bio-active sites configured to attract and retain calcium and phosphorous cations. The transition zone is disposed between the metal substrate and the ceramic coating. The transition zone includes a concentration gradient transitioning from the metal substrate to the ceramic coating and there is no distinct interface between the metal substrate and the ceramic coating.

A femoral head arthroplasty system can comprise a femoral prosthesis comprising a mounting plate having a first side and an opposed second side. An adapter can extend from the second side of the mounting plate. An implant body can extend from the first side of the mounting plate. The implant body can extend from the mounting plate by a distance no greater than 90 mm. The femoral head arthroplasty system can further comprise a femoral head replacement having a generally spherical surface and comprising a recess that is shaped to complementarily receive the adapter of the femoral prosthesis.

An orthopaedic knee implant includes a femoral component having a substrate and a coating disposed on the surface of the substrate. A method for making a femoral component of an orthopaedic knee implant is also disclosed.

The invention relates to a ceramic surface arthroplasty system, which consists of a convex, hemispherical, metallic implant (1) and a hollow hemispherical metal implant (3). The implants are coated with porcelain or zirconium oxide layer on their friction surfaces to avoid the creation of metallic microparticles. The convex implant (1) has a navel (4) on the thread (6) of which a bone-piercing pre-tensioning needle (7) is screwed and is tightened with a washer (9) at the area of the major trochanter or bulge. Further, it has protruding ribs (5) immersed on the surface of the head.

A femoral head arthroplasty system can comprise a femoral prosthesis comprising a mounting plate having a first side and an opposed second side. An adapter can extend from the second side of the mounting plate. An implant body can extend from the first side of the mounting plate. The implant body can extend from the mounting plate by a distance no greater than 90 mm. The femoral head arthroplasty system can further comprise a femoral head replacement having a generally spherical surface and comprising a recess that is shaped to complementarily receive the adapter of the femoral prosthesis.

An orthopaedic implant can replace a joint in a patient. The orthopaedic implant includes a first component having a first component surface and a second component having a second component surface. The first component surface and the second component surface mate at an interface. The first component surface includes a metal substrate, a nanotextured surface, a ceramic coating, and a transition zone. The nanotextured surface is disposed directly upon the metal substrate and has surface features in a size of 10.sup.9 meters. The ceramic coating conforms to the nanotextured surface and includes a plurality of bio-active sites configured to attract and retain calcium and phosphorous cations. The transition zone is disposed between the metal substrate and the ceramic coating. The transition zone includes a concentration gradient transitioning from the metal substrate to the ceramic coating and there is no distinct interface between the metal substrate and the ceramic coating.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.