The Pressure Regulating Oral Appliance is an oral appliance which is designed to reduce reflux. The device prevents the buildup of negative pressure within the oral cavity that can create a vacuum promoting reflux of stomach content through the LES.

The present invention relates to an intra-oral device including a carrier that has an outside wall, an inside wall and an occlusal wall connecting the outside wall to the inside wall. The carrier has at least one inset and at least one insert carrying a beneficial agent that is adapted to fit the inset, and the beneficial agent is capable of promoting weight loss. The intra-oral device is positioned in a user's mouth so that the intra-oral device is in contact with the user's cheeks, lips and/or tongue and the beneficial agent passes through the mucosal membrane of the user's mouth.

A retainerless orthodontic dental implant system for positioning the mandible forward relative to the maxilla and for facilitating optimal airflow during sleep and a method of using such a system.

An oral weight control device that inhibits the mastication and swallowing of food is provided. The oral weight control device is a dental appliance that includes upper and lower retainers, where each retainer covers the lingual, palatal and buccal side of the teeth to inhibit mastication of food. The dental appliance further includes left and right flexible food barriers extending from the upper retainer to the lower retainer on the lingual side of the teeth to prevent food that a user may attempt to masticate between the upper and lower retainers from being passed to the tongue of the user to ingest. The upper and lower retainers may be customized to fit on each user and may cover all the upper and lower teeth of the wearer on the lingual, palatal and buccal sides of the teeth. The retainers may be removable or semi-permanently secured to the teeth. The flexible material is made of an elastic material and/or is sized to allow the jaws of the wearer to be fully opened and closed when the dental appliance is worn.

Certain configurations of methods of using removable oral devices are described. In some examples, a removable oral device can be used in weight loss, weight management, athletic performance or in other applications to monitor or alter a user's behavior or monitor one or more physiological conditions. If desired, the removable oral device can be used in combination with a storage case, a mobile device, application software or other components.

Certain configurations of removable oral devices are described. In some instances, the removable oral device includes a palatal element. In certain configurations, the palatal element may comprise a variable hardness at different areas, e.g., edges can be softer than other areas of the removable oral device. In other instances, the removable oral device may comprise two or more individual palatal elements which together can form the palatal element and permit user adjustment of the oral volume. Various materials used in the palatal element are described. Sensors and other on-board devices are also described.

Certain configurations of methods which can be used to produce removable oral devices are described. In some instances, the removable oral devices can be produced using molding, digital scanning, on demand printing and/or other processes. In certain examples, the produced removable oral device can be used in weight management, athletic performance or in other applications.

The invention provides methods to prepare protein conjugates from proteins having at least two cysteines. In one embodiment, a protein with a disulfide linkage is reduced to provide two free cysteines for reaction with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of the two cysteines together. The ketone inserted between the sulfur atoms is then used to form a Schiff base to an aminated payload molecule, thus conjugating the protein to a payload. In another embodiment, two cysteine residues are tied together by reaction with a 1,3-dihaloacetone or similar reactant. The linkage between the sulfur atoms in each case holds the protein or peptide in a constrained conformation, while also providing a convenient place for attaching a payload with good specificity and efficiency.

An oral weight control device that inhibits the mastication and swallowing of food is provided. The oral weight control device is a dental appliance that includes upper and lower retainers, where each retainer covers the lingual, palatal and buccal side of the teeth to inhibit mastication of food. The dental appliance further includes left and right flexible food barriers extending from the upper retainer to the lower retainer on the lingual side of the teeth to prevent food that a user may attempt to masticate between the upper and lower retainers from being passed to the tongue of the user to ingest. The upper and lower retainers may be customized to fit on each user and may cover all the upper and lower teeth of the wearer on the lingual, palatal and buccal sides of the teeth. The retainers may be removable or semi-permanently secured to the teeth. The flexible material is made of an elastic material and/or is sized to allow the jaws of the wearer to be fully opened and closed when the dental appliance is worn.

Certain configurations of removable oral devices are described. In some instances, the removable oral device includes a palatal element. In certain configurations, the palatal element may comprise a variable hardness at different areas, e.g., edges can be softer than other areas of the removable oral device. In other instances, the removable oral device may comprise two or more individual palatal elements which together can form the palatal element and permit user adjustment of the oral volume. Various materials used in the palatal element are described. Sensors and other on-board devices are also described.