Various features are described that are adapted to improve performance of interference-relief type delivery systems. A delivery system provided herein comprises an implant comprising a socket at a proximal end of the implant; an elongate sleeve having (i) a proximal section, (ii) a distal section slidably disposed within the socket, and (iii) a window between the proximal section and the distal section, the window extending through a wall of the sleeve; and a core member having a proximal portion slidably received within the proximal section of the sleeve and a distal portion extending through the window to a space outside the sleeve and within the socket. The distal portion of the core member provides an interference fit with the distal section of the sleeve within the socket until the core member is withdrawn.

An intrauterine device for preventing egg fertilization having a membrane, a frame having a first arm and a second arm, the first and second arms movable from a first position to a second more expanded position. The frame supports the membrane to move the membrane between a first position to a second more expanded position, wherein the first and second arms are non-planar and each arm has a proximal portion, an intermediate portion and a distal portion, The first arm has a bend at the intermediate portion so that the intermediate portion of the first arm lies in a different plane than the proximal portion of the first arm and the second arm has a bend at the intermediate portion so the intermediate portion of the second arm lies in a different plane than the proximal portion of the second arm. An elongated tail portion extends proximally of the membrane. The membrane can have a convex distal portion.

An implantable and/or injectable device made of biodegradable material which comprises two hollow volumes where said device comprises a cylinder, which comprises a top portion and a bottom portion, where the top end and bottom end of said cylinder are open and via said openings on said top and bottom ends a first hollow volume and a second hollow volume are respectively accessed, where said first hollow volume and second hollow volume are separated from each other by a partition and are characterized in that the side wall of said first hollow volume has a thickness which is smaller than the thickness of the side wall of said second hollow volume. A method for manufacturing, filling with at least one active agent and closing said device and the use of the said device filled with at least one active agent for the treatment and/or the prevention of pathologies which require repeated and programmed administration over time.

An intrauterine device for preventing egg fertilization having a membrane, a frame having a first arm and a second arm, the first and second arms movable from a first position to a second more expanded position. The frame supports the membrane to move the membrane between a first position to a second more expanded position, wherein the first and second arms are non-planar and each arm has a proximal portion, an intermediate portion and a distal portion, The first arm has a bend at the intermediate portion so that the intermediate portion of the first arm lies in a different plane than the proximal portion of the first arm and the second arm has a bend at the intermediate portion so the intermediate portion of the second arm lies in a different plane than the proximal portion of the second arm. An elongated tail portion extends proximally of the membrane. The membrane can have a convex distal portion.

An intrauterine device for preventing egg fertilization having a membrane, a frame having a first arm and a second arm, the first and second arms movable from a first position to a second more expanded position. The frame supports the membrane to move the membrane between a first position to a second more expanded position, wherein the first and second arms are non-planar and each arm has a proximal portion, an intermediate portion and a distal portion, The first arm has a bend at the intermediate portion so that the intermediate portion of the first arm lies in a different plane than the proximal portion of the first arm and the second arm has a bend at the intermediate portion so the intermediate portion of the second arm lies in a different plane than the proximal portion of the second arm. An elongated tail portion extends proximally of the membrane. The membrane can have a convex distal portion.