The technology disclosed herein generally concerns a system and method for reversibly occluding a body lumen.

The technology disclosed herein generally concerns a system and method for reversibly occluding a body lumen.

A flexible implantable contraceptive disc device is disclosed which can be inserted inside the female body, such as inside the uterus, is disclosed. The disc device can be bent and inserted into a laparoscopy tube, which allows it to be delivered to an appropriate location inside a female subject. The disc device has three layers, a central core silicon reservoir containing an active ingredient, such as a contraceptive progesterone, which is sandwiched and encased by upper and lower porous silicon casings. The casings are porous to the contraceptive, allowing controlled release over a prolonged period of time. The lower casing has a series of micro-hooks around a circumference, allowing the disc device to be attached to a desired tissue by rotating the disc device such that the hooks engage with the desired tissue. Such a device is easier to insert, and to remove, than a rod-like rigid plastic T-shape IUDs which are considerably larger, also and more expensive to manufacture.

A flexible implantable contraceptive disc device is disclosed which can be inserted inside the female body, such as inside the uterus, is disclosed. The disc device can be bent and inserted into a laparoscopy tube, which allows it to be delivered to an appropriate location inside a female subject. The disc device has three layers, a central core silicon reservoir containing an active ingredient, such as a contraceptive progesterone, which is sandwiched and encased by upper and lower porous silicon casings. The casings are porous to the contraceptive, allowing controlled release over a prolonged period of time. The lower casing has a series of micro-hooks around a circumference, allowing the disc device to be attached to a desired tissue by rotating the disc device such that the hooks engage with the desired tissue. Such a device is easier to insert, and to remove, than a rod-like rigid plastic T-shape IUDs which are considerably larger, also and more expensive to manufacture.

Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.

Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 μL-1,000 μL) of volume.

A device for occluding a tubular body lumen that includes a structure having a proximal and a distal end and having a means for securing said device to the wall of a fallopian tube prior to tissue in-growth; the device for occluding a tubular body lumen wherein the device is constructed from a radio-opaque substance; the distal end of the occlusion device includes a connection means for connecting to an insertion rod; wherein said device has a plurality of spikes, bumps, grooves, protrusions to secure said device to the wall of a fallopian tube prior to tissue in-growth and removal of an insertion rod; wherein said device having one of a rigid outer or semirigid outer construction; The occluding device having one of a smooth, a porous, and a combination smooth and porous surface; wherein the occluding device includes antimicrobial properties; wherein the proximal and distal ends of the device comprise a circular shape, an oval shape, a half oval shape, a cylindrical shape, a cone shape, a bullet shape, a sphere shape or a combination thereof; and wherein the occluding device is one of a solid, hollow, and a combination of solid and hollow.

A device for occluding a tubular body lumen that includes a structure having a proximal and a distal end and having a means for securing said device to the wall of a fallopian tube prior to tissue in-growth; the device for occluding a tubular body lumen wherein the device is constructed from a radio-opaque substance; the distal end of the occlusion device includes a connection means for connecting to an insertion rod; wherein said device has a plurality of spikes, bumps, grooves, protrusions to secure said device to the wall of a fallopian tube prior to tissue in-growth and removal of an insertion rod; wherein said device having one of a rigid outer or semirigid outer construction; The occluding device having one of a smooth, a porous, and a combination smooth and porous surface; wherein the occluding device includes antimicrobial properties; wherein the proximal and distal ends of the device comprise a circular shape, an oval shape, a half oval shape, a cylindrical shape, a cone shape, a bullet shape, a sphere shape or a combination thereof; and wherein the occluding device is one of a solid, hollow, and a combination of solid and hollow.

Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G) and an initial loss modulus (initial G″) when initially combined such that a ratio of the initial G″ to the initial G is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G) and a gelation loss modulus (gelation G″) at a gelation time after the first component and the second component are combined such that a atio of the gelation G″ to the gelation G is less than about 1. The gelation time is less than about 120 seconds.

Delivery systems, compositions, and methods for forming and delivering biomaterials from two components are described. Specifically, a composition includes a first component and a second component that are each formulated to be crosslinked with the other to form a hydrogel. The first component and the second component are formulated to have an initial storage modulus (initial G) and an initial loss modulus (initial G″) when initially combined such that a ratio of the initial G″ to the initial G is between about 5 and about 100. The first component and the second component are formulated to have a gelation storage modulus (gelation G) and a gelation loss modulus (gelation G″) at a gelation time after the first component and the second component are combined such that a atio of the gelation G″ to the gelation G is less than about 1. The gelation time is less than about 120 seconds.