A system for delivering an injection of a fluid into a void within a subject is disclosed. A barrel extends from a first end to a second end and forms a lumen extending from the first end to the second end. A plug and a floating seal are arranged within the lumen. A hollow needle includes a distal end with an opening for fluid to flow from the lumen. The plug, the barrel and the floating seal include material and dimensions selected based on a threshold flowrate for a fluid arranged within the lumen to: overcome a force opposed to a force being applied to the fluid in the lumen to move the floating seal and the hollow needle into a tissue of the subject, and succumb to the opposing force to displace the fluid through the opening into the void.

Disclosed are various embodiments for an apparatus for installation of eye drops, an automatic dispensing device, and a method to dispense eye drops. The apparatus including a dispensing device, a control system, and a housing. The dispensing device configured to dispense a dosage of a fluid medication from an eye drop bottle, the eye drop bottle having an opening. The control system operatively connected to the dispensing device. The housing comprising a main wearable headset and a cover. The housing configured to contain the dispensing device and the control system, and configured to allow passage of the dosage of the fluid medication through an aperture in the main wearable headset of the housing. Also, disclosed is an automatic dispensing device comprising a motor and detection system to dispense a fluid from a bottle.

A system for positioning a conduit within an ophthalmic surgical field comprises a conduit (12), a first fixation point (14) and a second fixation point (15). The first fixation point (14) comprises base structure (16) arranged to be secured in a fixed location, and a grip arrangement (18) configured to hold the conduit (12). The grip arrangement (18) is mounted on the base structure (16) by way of a ball joint structure (20, 22), with the ball joint structure (20, 22) being arranged to allow pivoting and rotational movement of the grip arrangement (18) with respect to the base structure (16). The second fixation point (15) is positioned remote from the first fixation point (14) at a predefined distance therefrom. A method for positioning a conduit with an ophthalmic surgical field is also described.

Methods and kits for treating or preventing an eye condition or for cleaning an eye area tissue are provided. A method of the invention includes administering an isoprenoidal essential oil to eye area tissue, chafing eye area tissue with an abrasive, and removing the abrasive. A kit according to the invention includes an isoprenoidal essential oil, an abrasive for chafing eye area tissue, and in instruction for use for treating an eye condition or cleansing an eye area tissue. The invention also includes a composition of matter comprising an isoprenoidal essential oil and a plurality of abrasive particles in ophthamologically acceptable base.

Lacrimal implants, methods of making lacrimal implants, and methods of treating ocular, respiration or other diseases or disorders using lacrimal implants are disclosed.

A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.

An adherence device 100, including an attachable component to secure to an eye drop bottle cap and a monitoring component 110. The monitoring component 110 includes a sensor 170 to detect each eye drop administration. The attachable camponent may be a “universal cap” capable of securing onto any eye drop bottle cap while still permitted normal FDA-approved water-tight closure. The cap is capable of being removed and transferred to a different eye drop bottle for reuse.

A fluid dispensing device includes a light source, and a nozzle spaced from the light source. The device also includes a membrane positioned within a beam path of the light source, where the membrane is configured to allow a portion of light from the light source through to the nozzle. The device also includes a fluid chamber positioned between the membrane and the nozzle, where the nozzle is configured to allow a beam of the portion of light to pass through along the beam path, and where the nozzle is further configured to form a stream of fluid expelled from the fluid chamber along the beam path.

Described here are systems and methods for accessing Schlemm’s canal and for delivering an ocular device or fluid composition therein. The ocular devices may maintain the patency of Schlemm’s canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

A contact lens product having a cornea repair function includes a composition in the form of a solution. The composition includes gold nanoparticles and at least one auxiliary repairing ingredient. The gold nanoparticles are present in an effective concentration from 0.01 ppm to 3000 ppm and have an average particle size from 0.01 nm to 100 nm. The at least one auxiliary repairing ingredient is selected from the group consisting of chondroitin sulfate, α-lipoic acid, 2-aminoethanesulfonic acid, and potassium L-aspartate and present in an amount greater than 0 wt % and less than 20 wt % based on the composition being 100 wt %.