The present disclosure relates generally to small-gauge instrumentation for surgical procedures, and more specifically, to vitreoretinal instruments for retinal repair and reattachment procedures, as well as associated methods of use. Certain embodiments of the present disclosure provide a curved or articulating probe configured to provide illumination, fluid aspiration, and endophotocoagulation. Accordingly, the probe enables aspiration of subretinal fluid that re-accumulates after initial drainage and during endophotocoagulation without the need to exchange surgical instruments or insert an additional instrument into the intraocular space. Furthermore, the combined functionalities of the probe enable a surgeon to simultaneously perform scleral depression with the surgeon's other hand while aspirating fluid and/or performing retinal endophotocoagulation.

A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.

A foldable pressing-type balloon structure (10), comprising a balloon body (100) used for arrangement in the Tenon capsule and a drainage component (200) capable of being closed automatically. The balloon body (100) is formed with a balloon cavity used for supplying normal saline or air; the balloon body (100) has a planar first surface (110) and a curved second surface (120); the height of the balloon body (100) along the first surface (110) is 0.2-2.0 cm; the drainage component (200) is connected to the second surface (120) of the balloon body (100) and communicated with the balloon cavity. The foldable pressing-type balloon structure (10) is implanted under the Tenon capsule, and a break is sealed by pressing by filling the inside of the balloon body (100) with a medium. Compared with scleral buckles in the prior art, fixing with buckles is not required, and it is only necessary to fix the position of the drainage component (200) by suturing to prevent displacement, so that an incision in surgery is reduced; moreover, because fixing with buckles is not required, extraocular muscles will not be pulled, so that a patient does not feel uncomfortable after surgery. The surgical method is simple in operation, the difficulty is reduced, and the time required for surgery is shortened.

A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), and wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.

Embodiments disclosed herein provide devices, systems, and methods for instrument exchanges during ophthalmic surgery. More particularly, the present disclosure relates to valved cannula assemblies and methods of use thereof. A valved cannula assembly includes a cannula having a head at a proximal end of the cannula and a hollow rod extending from the head to a distal end of the cannula. The valved cannula assembly includes a valved hub coupled to the head and including a septum having two or more curved flaps configured to provide an opening for an instrument.

A gas mixing system for providing mixed gas for intraocular injection. In some embodiments, a first fixed-volume chamber is automatically purged and filled with gas from a first gas supply input, to a first predetermined pressure. A second fixed-volume chamber is purged and filled with gas from a second gas supply input, to a second predetermined pressure. The first and second predetermined pressures are determined based on a desired concentration of gases in the final mix, and the respective volumes of the first and second fixed-volume chambers and of a third fixed-volume chamber. Gas from the first fixed-volume chamber is then allowed to mix with gas in the third fixed-volume chamber, which was previously purged. Next, gas from the second fixed-volume chamber is allowed to mix with gas in the third fixed-volume chamber. Finally, the mixture of gases in the third fixed-volume chamber is expressed into an intraocular syringe.

Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

A handheld implantation device for implantation of a retinal tissue implant at an implantation site. The handheld implantation device includes a handheld implantation tool having a leading implantation tool end and a trailing implantation tool end, an implant holder for peripherally holding a retinal tissue implant including an uppermost viable retinal tissue and a lowermost basement membrane and a clinician-operated attachment arrangement for initial attaching the implant holder at the leading implantation tool end and subsequent selected detaching the implant holder therefrom at the implantation site for implantation of the implant holder together with the retinal tissue implant thereat.

Methods and systems for performing an ophthalmic surgical treatment procedure include one or more wicking members to secure a volume of treatment fluid to a distal end of a surgical instrument. Such a surgical instrument may include an elongate tubular member having a proximal end, a distal end, and a lumen extending therebetween, the elongate tubular member being configured to penetrate a body cavity of a patient. The instrument may further include a wicking member extending beyond the distal end of the elongate tubular member. The wicking member may be configured to secure a volume of treatment fluid delivered through the lumen to the wicking member for application from the wicking member to target tissue in the body cavity.

Devices, systems and methods for applying a bioadhesive substance to an internal surface of the eye, such as the retina, can include an outer sleeve having a proximal end, a distal end, a passageway extending along a length of the elongate body and an opening at the distal end of the elongate body, an applicator tip including an elongate body having a proximal end and a distal end, an applicator portion coupled with the distal end of the elongate body, and a substance supply lumen extending along a length of the device through which a bioadhesive substance can pass so that the bioadhesive substance can be applied to at least the applicator portion of the applicator tip. Some embodiments of the device can also have a source of the bioadhesive substance in fluid communication with at least the substance supply lumen.