The invention relates to a method for controlling a laser (12) of a treatment apparatus (10), comprising the steps of: generating a plurality of laser pulses (34) with a predefined energy below a photodisruption regime of a polymer material (26), irradiating the area (16) with the laser pulses (34), wherein a refractive index of the polymer material (26) changes at the irradiated irradiation point (36) depending thereon, generating a first irradiation line (38) in a first depth plane (40), wherein the first depth plane (40) is formed substantially perpendicularly to an optical axis (20) of the area (16), generating a second irradiation line (42) in a second depth plane (44) different from the first depth plane (40), wherein the first depth plane (40) and the second depth plane (44) overlap at least in certain areas viewed in the direction of the optical axis (20) and the second depth plane (44) is formed substantially perpendicularly to the optical axis (20). Further, the invention relates to a treatment apparatus (10), to a computer program, to a computer-readable medium as well as to a surgical method.

Systems and methods are provided for measuring the mechanical properties of ocular tissue, such as the lens or corneal tissue, for diagnosis as well as treatment monitoring purposes. A laser locking feedback system is provided to achieve frequency accuracy and sensitivity that facilitates operations and diagnosis with great sensitivity and accuracy. Differential comparisons between eye tissue regions of a patient, either on the same eye or a fellow eye, can further facilitate early diagnosis and monitoring.

In some embodiments, an ophthalmic laser system may be provided that does not include a traditional laser console. Instead, the treatment device may be configured to house the treatment light source within the device handle. Additionally, in some embodiments, the handheld treatment device may include a user interface, such as dials and buttons, for adjusting various parameters of the therapeutic light. With certain embodiments, the self-contained handheld treatment device may be operated independent of an AC power source. For example, in some embodiments, the handheld treatment device may be battery powered. Additionally, the handheld treatment device may be disposable or may utilize replaceable distal tips in certain embodiments. Certain embodiments may be particularly designed for transscleral cyclophotocoagulation. Also, treatment guides are provided that may be configured to couple with a treatment device to align the device with a target tissue of the eye.

A method of treatment of the cornea of an eye including exposing the cornea to a crosslinking medium, and applying a mechanical loading to the cornea, wherein the mechanical loading is selected as a strain proportional to the dimensions of the eye being treated. A method of altering the curvature of the cornea is provided including controlling a light source to apply light energy pulses to corneal tissue; wherein the light energy pulses are below an optical breakdown threshold for the cornea; ionize water molecules within the treated corneal layer to generate reactive oxygen species; and initiate crosslinking within the extracellular matrix of the cornea to change the physical properties of the cornea, e.g., the stiffness of the cornea.

A method of treatment of the cornea of an eye including exposing the cornea to a crosslinking medium, and applying a mechanical loading to the cornea, wherein the mechanical loading is selected as a strain proportional to the dimensions of the eye being treated. A method of altering the curvature of the cornea is provided including controlling a light source to apply light energy pulses to corneal tissue; wherein the light energy pulses are below an optical breakdown threshold for the cornea; ionize water molecules within the treated corneal layer to generate reactive oxygen species; and initiate crosslinking within the extracellular matrix of the cornea to change the physical properties of the cornea, e.g., the stiffness of the cornea.

The present disclosure relates generally to small-gauge instrumentation for surgical procedures, and more specifically, to vitreoretinal instruments for retinal repair and reattachment procedures, as well as associated methods of use. Certain embodiments of the present disclosure provide a curved or articulating probe configured to provide illumination, fluid aspiration, and endophotocoagulation. Accordingly, the probe enables aspiration of subretinal fluid that re-accumulates after initial drainage and during endophotocoagulation without the need to exchange surgical instruments or insert an additional instrument into the intraocular space. Furthermore, the combined functionalities of the probe enable a surgeon to simultaneously perform scleral depression with the surgeon's other hand while aspirating fluid and/or performing retinal endophotocoagulation.

In some examples, a distributed acoustic detector system may include a frame structure and multiple acoustic detectors. The frame structure may be configured to be retained in a laser-based ophthalmo-logical surgical system aligned to an eye of a patient during therapeutic treatment of the eye of the patient with the laser-based ophthalmological surgical system. The acoustic detectors may be coupled to the frame structure and may be spaced apart from each other and electrically separated from each other.

In some examples, a distributed acoustic detector system may include a frame structure and multiple acoustic detectors. The frame structure may be configured to be retained in a laser-based ophthalmo-logical surgical system aligned to an eye of a patient during therapeutic treatment of the eye of the patient with the laser-based ophthalmological surgical system. The acoustic detectors may be coupled to the frame structure and may be spaced apart from each other and electrically separated from each other.

In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation with a first wavelength. The system may also include a probe radiation source configured to emit probe radiation with a second wavelength different than the first wavelength. The system may also include one or more optical elements configured to direct the therapeutic radiation and the probe radiation into an eye of a patient and to collect reflected probe radiation from the eye of the patient. The reflected probe radiation may be indicative of an amount of therapeutic radiation exposure of the eye of the patient. The system may also include a photodetector configured to receive the reflected probe radiation from the one or more optical elements and to generate a photocurrent indicative of the amount of therapeutic radiation exposure of the eye of the patient.

In a laser cataract procedure that also corrects for astigmatism, an iris registration method compares an iris image of a patient's eye taken when the eye is not docked to a patient interface device with an iris image of the same eye that is docked to the patient interface, to calculate a rotation angle between the two images. The astigmatism axis of the eye is measured when the eye is not docked, and the measured axis is rotated by the calculated rotation angle to obtain a rotated astigmatism axis relative to the iris image of the docked eye. The laser cataract procedure is performed based on the rotated astigmatism axis. The rotation angle is calculated by optimizing a transformation that transforms the undocked iris image to match the docked iris image, where the transformation includes a dilation factor that accounts for different pupil dilation of the two iris images.