Systems, products, compounds, and methods can be applied and/or used by a person to facilitate and promote the production of nitric oxide to be used by a person for health benefits. The systems, products, and devices include a nitric oxide bath system. The systems and methods can comprise one or more compounds that when mixed are adapted to produce nitric oxide gas, with at least one nitrite compound and at least one acid compound. The nitric oxide gas may then be delivered to a user transdermally via one or more bath applications.

A device is provided for controlling the nitric oxide levels within the lungs of a subject. The device comprises a detector for detecting the respiration cycle of the subject and a stimulator for applying an acoustic or vibratory stimulus to the subject. The stimulator is controlled in dependence on the detected respiration cycle. In particular, acoustic stimulation may be provided at the onset of inspiration. In this way, the nitric oxide flow can be controlled in a way to ensure that the paranasal nitric oxide is nearly fully inspired. This provides a higher nitric oxide concentration in the lung/alveoli.

The present invention relates to a medical bathing equipment for the manufacture and use of a bathing solution containing an active substance and in particular a bathing solution containing NO. The invention also relates to a bathing equipment based on a multi-stage method for generating NO and the bathing equipment in its use for the treatment of diseases, in particular of diabetically caused circulatory disorders and wounds of the lower extremities.

An NO-accumulation apparatus, method and use, comprising: a container (120) defining a cavity for accommodating a liquid (105), an inlet (150) for feeding the liquid into the container (120) and an outlet (151) for delivering the liquid from the container (120) to a bath unit; an NO-gas dissolving unit (140) for dissolving gaseous NO in the liquid (105) to produce an NO-containing liquid, wherein the NO-gas dissolving unit (140) is arranged in the container (120) and/or forms a part of the container (120); and an NO-gas port (110) in fluid communication with the NO-gas dissolving unit (140), wherein the NO-gas port (110) is adapted for coupling, particularly for releasably coupling, with an NO-gas supply, whereby the apparatus further comprises means for decoupling the inflow of NO to the liquid (105) within the container from the removal of the NO-containing liquid (NO-decoupling means), so that the removal of the NO-containing liquid is inhibited, when the NO is flowing into the liquid, and also the NO inflow is inhibited when the NO-containing liquid is removed from the container (105).

A nitric oxide repletion system in accordance with an embodiment of the present technology may disperse therapeutic constituents into a reservoir holding a body of liquid. The nitric oxide repletion system may comprise a reservoir, and a liquid circulation system for generating a fluid flow comprising a pump, a main liquid conduit, a venturi injector, an ultrafine bubble (UFB) generator, a main return, a nitric oxide dispensing system and a mineral dispensing system. The nitric oxide repletion system may further comprise a control panel. In some embodiments, the nitric oxide repletion system may further comprise a gas supply and a gas injector system for supplying a desired gas to the venturi injector or the UFB generator.

A device is provided for controlling the nitric oxide levels within the lungs of a subject. The device comprises a detector for detecting the respiration cycle of the subject and a stimulator for applying an acoustic or vibratory stimulus to the subject. The stimulator is controlled in dependence on the detected respiration cycle. In particular, acoustic stimulation may be provided at the onset of inspiration. In this way, the nitric oxide flow can be controlled in a way to ensure that the paranasal nitric oxide is nearly fully inspired. This provides a higher nitric oxide concentration in the lung/alveoli.

The present invention relates to a medical bathing equipment for the manufacture and use of a bathing solution containing an active substance and in particular a bathing solution containing NO. The invention also relates to a bathing equipment based on a multi-stage method for generating NO and the bathing equipment in its use for the treatment of diseases, in particular of diabetically caused circulatory disorders and wounds of the lower extremities.

An NO-accumulation apparatus, method and use, comprising: a container (120) defining a cavity for accommodating a liquid (105), an inlet (150) for feeding the liquid into the container (120) and an outlet (151) for delivering the liquid from the container (120) to a bath unit; an NO-gas dissolving unit (140) for dissolving gaseous NO in the liquid (105) to produce an NO-containing liquid, wherein the NO-gas dissolving unit (140) is arranged in the container (120) and/or forms a part of the container (120); and an NO-gas port (110) in fluid communication with the NO-gas dissolving unit (140), wherein the NO-gas port (110) is adapted for coupling, particularly for releasably coupling, with an NO-gas supply, whereby the apparatus further comprises means for decoupling the inflow of NO to the liquid (105) within the container from the removal of the NO-containing liquid (NO-decoupling means), so that the removal of the NO-containing liquid is inhibited, when the NO is flowing into the liquid, and also the NO inflow is inhibited when the NO-containing liquid is removed from the container (105).