Systems, and methods relate to a medical device receiving a treatment parameter operating point within a first operating region defined by a first set of operating points for which automatic incremental adjustment of a parameter in the current operation is permitted. In an illustrative example, incremental adjustment may use artificial intelligence based on patient feedback and sensor measurement of outcomes. Some exemplary devices may receive a request to alter the current treatment parameter operating point to a second treatment parameter operating point outside the first operating region and in a second operating region in a known safe operation zone, bounded by a known unsafe zone unavailable to the user. In the second operating region, some examples may restrict the step size of incremental adjustments requested by the user. Data may be collected for cloud-based analysis, for example, to facilitate discovery of more effective treatment protocols.

A portable automated life-saving system, comprising one or more sensors utilized for collecting data related to a patient's current medical condition and to transmit the collected data to a main computer; a main computer adapted with suitable hardware and software to process data, received from the one or more sensors, with respect to predefined medical conditions and corresponding life-saving treatment protocols, thereby to determine an initial life-saving treatment protocol to be delivered to the patient, and accordingly to operate a main controller configured to activates corresponding life-saving devices; a main controller adapted to be operated by the main computer, for controllably activating fastening means, and for controllably activating one or more life-saving devices for delivering life-saving treatment to the patient; two or more fastening means, controllably activated by the main controller for obtaining a firm attachment of the automated life-saving system to a patient; one or more life-saving devices controllably activated by the main controller for delivering life-saving treatment to the patient; one or more batteries. The portable automated life-saving system continuously monitors the evolving medical condition of a patient, and correspondingly adapts the given treatment, namely, the operation of the one or more life-saving devices.

Systems, and methods relate to a medical device receiving a treatment parameter operating point within a first operating region defined by a first set of operating points for which automatic incremental adjustment of a parameter in the current operation is permitted. In an illustrative example, incremental adjustment may use artificial intelligence based on patient feedback and sensor measurement of outcomes. Some exemplary devices may receive a request to alter the current treatment parameter operating point to a second treatment parameter operating point outside the first operating region and in a second operating region in a known safe operation zone, bounded by a known unsafe zone unavailable to the user. In the second operating region, some examples may restrict the step size of incremental adjustments requested by the user. Data may be collected for cloud-based analysis, for example, to facilitate discovery of more effective treatment protocols.

A method and system of sleep maintenance includes configuring a stimulation device comprising a transducer to emit a transcutaneous vibratory output to a body part of a subject, receiving physiological data of the subject from at least one sensor at a processor, providing a stimulation pattern for the transcutaneous vibratory output to be emitted by the transducer, the stimulation pattern comprising a perceived pitch, a perceived beat, and an intensity of the transcutaneous vibratory output, causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern, determining a sleep state of the subject based on the physiological data, and altering the stimulation pattern based on the sleep state, wherein altering comprises at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Systems and methods disclosed herein relate to augmenting a treatment modality. A method of providing stimulation therapy to a user may include generating transcutaneous vibratory output comprising one or more variable parameters, subjecting the user, in conjunction with the transcutaneous vibratory output, to a treatment modality, wherein the one or more variable parameters of the transcutaneous vibratory output comprise at least one of a perceived pitch, a perceived beat, a perceived intensity, an envelope, or a base tone, and at least one of selecting or modifying the one or more variable parameters of the transcutaneous vibratory output to augment the treatment modality.

Systems and methods of assisting a subject to reach a target state include obtaining input of the target state of the subject; and generating a transcutaneous vibratory output to be applied to a portion of a body of the subject to assist the subject in achieving the target state, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity wherein the step of generating the transcutaneous vibratory output further comprises the step of modifying the variable parameters to correspond to the target state.

Certain pet products, such as collar, halters, pet beds, and the like, may be adapted to provide transcutaneous vibratory output. A device adapted to be worn by a non-human animal may include i) at least one of a collar or a harness structured to fit the non-human animal; and ii) at least one transducer located at least partially within the at least one collar or harness and structured to deliver a transcutaneous vibratory output to the non-human animal, the transcutaneous vibratory output having variable parameters comprising a perceived pitch, a perceived beat, and a perceived intensity.

Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Systems and methods disclosed herein relate to causing an epigenetic change in a user. The methods include measuring an epigenetic marker in the user, wherein the epigenetic marker is at least one of a regulation of a protein or a gene; or a methylation, acetylation, or phosphorylation status of at least one of a gene, histone, or portion of DNA. The methods further include subjecting a user to a first transcutaneous vibratory output selected to assist the user in achieving a target state, the first transcutaneous vibratory output comprising a first perceived pitch, a first perceived beat, and a perceived intensity, and repeating the measurement of the epigenetic marker to identify a change in an aspect of the epigenetic marker as a result of subjecting the user to the first transcutaneous vibratory output.

Delivering vibratory therapy to a user may include using a system with a first transducer adapted to emit a first transcutaneous vibratory output; a second transducer adapted to emit a second transcutaneous vibratory output; and a processor in electronic communication with a user interface, the first transducer, and the second transducer, wherein the user interface accepts a user target state. The processor may be programmed to (i) generate a first transcutaneous vibratory output pattern comprising a first perceived pitch, a first perceived beat, and a first intensity; (ii) generate a second transcutaneous vibratory output pattern comprising a second perceived pitch, a second perceived beat, and a second intensity; (iii) cause the first transducer to emit a first transcutaneous vibratory output based on the first transcutaneous vibratory output pattern; and (iv) cause the second transducer to emit a second transcutaneous vibratory output based on the second transcutaneous vibratory output pattern.