Customised polypills may be produced in the pharmacy from two or more drug packages using an assembly machine. Each drug package may comprise an array of cells containing individual doses of a single drug. The individual doses may be combined within the cells of the packages to produce an end user package with an array of cells containing the combined drugs in the form of individual polypills, which may be formed as capsules or pastilles. Label indicia of the drug packages may be combined together to form a composite label of the end user package. Serialization data may be read from the packages during assembly and sent to a remote server for authentication and supply chain management. In another aspect, patients who have a history of poor compliance with a prescribed oral antipsychotic while periodically seeking symptomatic relief from another prescribed psychoactive, are provided with both medicaments in the form of polypills to be taken in place of the solo antipsychotic when the patient is in crisis. Providing the preferred psychoactive as a combination motivates the patient to resume their antipsychotic therapy when symptoms return, which may result in better compliance and more effective management of psychosis in the community.

A blister pack may include a containing body with an opening; and a lid sealed over the opening and provided with a weakening pattern, wherein a width of the lid at the weakening pattern is thinner that a width of the lid elsewhere, and wherein the lid is configured to burst at the weakening pattern when the blister pack is subjected to pressure, so as to allow liquid content inside the containing body to be discharged out of the blister pack through the burst weakening pattern. A blister pack holder is also disclosed.

Embodiments are generally directed to systems and apparatuses for tracking usage of an item. For example, an apparatus may be provided for tracking use of a packetized item. The apparatus may include a microprocessor, a power source, and a structural layer to which the microprocessor and power source are coupled. The structural layer may include a container that is configured to hold various items. The container may also include an opening that allows access to the items. The apparatus may further include a cover layer that is configured to cover the opening of the container. The cover layer may include at least one bendable sensor placed over the opening of the container. The microprocessor may be configured to determine, using detected movements in the bendable sensor, whether the container has been opened.

Disclosed herein is a multidrug pain management package to dispense two or more medicaments to treat pain comprising a primary n-polygon, and one or more concentric m-polygons, wherein each side of the n-polygon and m-polygons have at least n or m-medicament chambers capable of holding the two or more medicaments. Also disclosed herein is a multidrug pain management package comprising a disk, wherein the disk is divided into equally spaced regions, and wherein each region has chambers capable of holding medicaments. Also disclosed herein are single formulations to treat pain.

A blister pack includes a housing having a plurality of cavities and a cover sealed to the housing and enclosing the cavities. The cover including a base layer, at least one security element, and a heat protective layer. The heat protective layer includes one of an amorphous polymer and a semi-crystalline polymer.

An evaluation device for monitoring the removal of medication from an electronically readable blister pack includes at least the following: an evaluation circuit able to be used to establish interruptions, destructions and/or other damages to electrical conductor tracks of a blister pack, wherein the evaluation circuit for this purpose tests or measures the electrical resistance, the capacitance or another parameter or state of the electrical conductor tracks of a blister pack, and a contact arrangement having a plurality of electrical contacts for contacting and/or otherwise evaluating the electrical conductor tracks of a blister pack, wherein the electrical contacts are connected to the evaluation circuit by electrical lines, wherein the evaluation device is an evaluation device which can be mounted on a wrapping-free and/or unwrapped blister pack.

A medicament dispensing container includes a first wall connected with a second wall and defines a cavity therebetween. The walls are movable between an open configuration and a closed configuration. At least one member is disposable in the cavity and defines at least one dose receptacle configured for disposal of at least one dose of at least one medication. At least one fixation member connects the at least one member to at least one of the walls such that the at least one member is movable relative to the wall. Systems and methods of use are disclosed.

Medication containers are provided with a body having a wireless communication device secured to a lower surface of the body. The wireless communication device includes an RFID chip and a slot-loop hybrid antenna electrically coupled to the RFID chip. The antenna includes a conductor sheet defining a slot and an aperture. The body defines a downwardly extending cell that is configured to receive a medication, with the aperture of the conductor sheet receiving at least a portion of the cell. The conductor sheet may include a plurality of apertures and the body may define a plurality of cells, with each aperture receiving a different one of the cells. A cover may be secured to an upper surface of the body to enclose the medication within the cell. If the medication container includes a plurality of cells and a frangible cover, it may be configured as a blister pack.

The present invention features a compound of formula I:

##STR00001##

or a pharmaceutically acceptable salt thereof, where R.sub.1, R.sub.2, R.sub.3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

This invention provides a blister pack dosage form container, comprising an advanceable blister pack holder, comprising a series of access portals sized to accommodate pass-through of at least one dosage form contained within a multi-dosage form containing blister pack located within said holder proximally therethrough upon engagement of an appropriate depilling structure, wherein said advanceable blister pack holder optionally accommodates upright positioning of said dosage forms and said depilling structure displaces said dosage form laterally. The invention also provides a multi-dosage form container, comprising an advanceable multi-sectioned dosage form holder, comprising a series of access portals sized to accommodate pass-through of at least one dosage form contained within said multi-sectioned dosage form holder proximally therethrough upon alignment with an appropriate egress structure, optionally wherein said multi-sectioned dosage form holder accommodates upright positioning of said dosage forms such that said egress structure provides for lateral displacement of said at least one dosage form; and a lockable outer container, comprising a tamper proof casing within which the multi-sectioned dosage form holder is contained. Kits containing the blister pack dosage form container and multi-dosage form containers are also described.