An aseptic closure system for attaching to a container including an upper section and a lower section that are removably attached to one another. Each section includes a valve housing with a rotary valve mounted in a bore extending through the valve housing. The upper section has an inlet port and an outlet port, each with a conduit providing fluid communication through the port to an interior of the upper valve housing. The lower section is adapted to mount to a container. The lower valve housing includes two conduits that permit fluid communication through the lower valve housing to an interior of the lower section. The rotation of the rotary valves closes off flow through the conduits in the respective housings.

A biopharmaceutical flow port, a biopharmaceutical liquid container assembly, and a method for manufacturing the biopharmaceutical flow port and the biopharmaceutical liquid container assembly are described. The biopharmaceutical flow port includes a hose barb coupled to an elliptic body. The hose barb includes a bore. The elliptic body includes a flow passage, a first edge, and a second edge. The flow passage is fluidly coupled to the bore. The first edge extends from the elliptic body away from the flow passage in a first direction and the second edge extends from the elliptic body away from the flow passage in a second direction opposite the first direction. The biopharmaceutical liquid container assembly includes a biopharmaceutical liquid container with an opening and the biopharmaceutical flow port coupled to the biopharmaceutical liquid container within the opening and in fluid communication with a volume of the biopharmaceutical liquid container.

A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.

An object is to provide a method for producing a port that can shorten the time for production. Provided is a method for producing a port including: sealingly inserting a sealing plug, through which a hollow needle can be pierced, into a part to be sealed of a port body, wherein the port body includes: a part to be sealed that has a tubular shape with a first end and a second end opposite to the first end; a connection part that has a tubular shape, and is continuous with the first end of the part to be sealed; and the part to be fitted that is formed in any one of an inner peripheral surface of the part to be sealed, an outer peripheral surface of the part to be sealed, and the second end of the part to be sealed; fitting a fitting part of a pulling-out prevention member into the part to be fitted, wherein the pulling-out prevention member includes: a body part that has a first surface and a second surface opposite to the first surface, and the fitting part that is continuous with the body part; and laying the body part on the sealing plug.

Container filling systems are described herein. A container filling system includes a container assembly, a nozzle, a first roller and a second roller. The container assembly includes a plurality of containers, each having a container volume and a fluid manifold defining a fluid pathway, wherein the fluid pathway is in fluid communication with the container volume of each of the plurality of containers. The nozzle is in fluid communication with the fluid pathway, wherein the nozzle directs flow from a fluid source into the fluid pathway. The nozzle separates the fluid manifold into a first portion and a second portion to permit the fluid manifold to advance relative to the nozzle.

An aseptic bioprocess package is provided herein. The aseptic bioprocess package includes a 2D flexible container including an interior compartment, a height having an upper half and a lower half, an inlet and an outlet, the inlet and the outlet being disposed on the same half of the 2D flexible container and a channel-forming feature in the interior compartment of the container, the channel-forming feature being configured to maintain a fluid flow path that fluidly connects the interior compartment of the flexible container with the outlet.

A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material, and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

A cap and seal system for a liquid medicament container. The system comprises a cap formed from a substantially rigid material and has a retention component integrally formed therewith. A seal is formed from a material which is less hard than the cap and positioned within the cap such that, when the retaining component retains the cap on a container in use the seal is positioned such that it forms a fluid tight seal between the cap and the container. A recess is formed in the seal through which a liquid outlet channel can pass in use to access the contents of the container via the cap and the seal.

The inner plug is mounted in an opening part of a container body and constitutes a nozzle part. The inner plug is constituted of a resin composite including a cyclic olefin copolymer and a polyethylene resin. A proportion of the cyclic olefin copolymer in 100 parts by weight of the resin composite is 25 to 85 parts by weight, a proportion of the polyethylene resin therein is 15 to 75 parts by weight, and a total amount of the cyclic olefin copolymer and the polyethylene resin is 80 to 100 parts by weight.

A port includes a conduit configured to receive a spike therein. The conduit includes a first portion, a second portion, and a septum fluidly separates the first portion and the second portion of the conduit. The septum is puncturable by the spike so as to allow the spike to be inserted into the second portion of the conduit. A removable snap portion extends from a break point to the tip of the port. The thickness of the break point is less than the thickness of the remainder of the conduit wall. The removable snap portion is configured to break away from the port at the break point such that the septum is accessible by the spike via the first portion of the conduit when the removable snap portion is broken away from the port. The port may include fluorinated ethylene propylene, ethylene tetrafluoroethylene, perfluoroalkoxy alkane, and combinations thereof.