A system for closed transfer of fluids includes a vial adapter having a body with a first end and a second end, a vial connection extending from the second end of the body, with the vial connection configured to secure the body to a vial, a vial spike extending from the second end of the body, with the vial spike defining a passageway, and a collet connection extending from the first end of the body. The system further includes a syringe adapter including a housing having a first end and a second end, a membrane housing positioned within the housing, with the membrane housing moveable between a first position and a second position, a cannula positioned within the housing, and a syringe connection extending from the first end of the housing, with the syringe connection configured to be secured to a syringe barrel.

A system for closed transfer of fluids includes a vial adapter having a body with a first end and a second end, a vial connection extending from the second end of the body, with the vial connection configured to secure the body to a vial, a vial spike extending from the second end of the body, with the vial spike defining a passageway, and a collet connection extending from the first end of the body. The system further includes a syringe adapter including a housing having a first end and a second end, a membrane housing positioned within the housing, with the membrane housing moveable between a first position and a second position, a cannula positioned within the housing, and a syringe connection extending from the first end of the housing, with the syringe connection configured to be secured to a syringe barrel.

A compact containment system comprises a mixing apparatus, a drying apparatus and a discharge apparatus. The mixing apparatus, which may be used to produce a slurry or solution mixture of solvent and dry powder during drug processing, comprises a dual compartment isolator for safely removing the dry powder from a dry powder container, a mixing vessel, and a negative cascading pressure controller. The drying apparatus comprises a drying unit, such as a thin film evaporator. The discharge apparatus comprises a discharge chute, a vacuum supply control valve, a product inlet valve, a gas control valve, a collection control valve and one or more collection containers The discharge chute comprises a substantially airtight internal chamber, a housing substantially surrounding the airtight internal chamber, a vacuum supply inlet that fluidly connects the airtight internal chamber of the discharge chute to a vacuum source, a solids inlet that fluidly connects the internal chamber to a product reservoir of the dryer, a gas inlet that fluidly connects the airtight internal chamber to a gas source, and a solids outlet that fluidly connects the airtight internal chamber to a collection container. The inlets and outlets are opened and closed by operation of flow control valves connected to those inlets and outlets in order to remove or admit gas to the discharge chute to effectively depressurize and re-pressurize the discharge chute, while moving dried pharmaceutical product out of the dryer and through the discharge chute. A flow diverter assembly directs on-spec material to a primary collection container and off-spec material to an auxiliary or waste collection container.

This disclosure relates to a multichamber device for administration of substances to a patient. The multichamber device comprises a first end comprising one or more ports and a second end opposite of the first end. The multichamber device further comprises a first plurality of septa and a second plurality of septa dividing the interior into a plurality of chambers, the first plurality of septa being parallel with the first end and configured to open, the second plurality of septa configured to remain sealed, the chambers further divided into a main chamber abutting the first end and being wider than the rest of the plurality of chambers and the rest of the plurality of chambers being organized into columns such that the columns extend from the second end to the main chamber and are oriented so that the first plurality of septa are configured to open toward the first end. The disclosure further relates to methods of using the multichamber device.

An apparatus to preserve a first fluid of a medicine vial is provided. The apparatus may include a vial coupling member comprising a housing and a flexible membrane. The housing and the flexible membrane form a vial coupling member cavity within the vial coupling member. The apparatus may also include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity. The apparatus may further include a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity. When the flexible membrane engages the medicine vial, the flexible membrane forms a sealed environment over a medicine vial septum. When the flexible membrane engages the medicine vial, the flexible membrane permits the first lumen and the second lumen to establish fluid communication with an interior space of the medicine vial.

A blood collection tube for physically separating the plasma and red blood cell fractions of a centrifuged sample is described. The blood collection tube has an elastomeric sleeve with rigid tube segments at both ends. Following blood collection and centrifugation, the elastomeric sleeve may be twisted to constrict its inner diameter and physically separate the two fractions. The blood collection tube may be secured in this position with a pin and a clamp, and further with an adhesive tape with pH paper. This enables blood samples to be transferred over long distances to a central lab facility without spoiling.

An apparatus to preserve liquid from a medicine vial may include a vial coupling member forming a vial coupling member cavity and a container forming a cavity. The apparatus may further include a first fluid pathway forming a first lumen that is in fluid communication with the vial coupling member cavity and the cavity and a second fluid pathway forming a second lumen that is in fluid communication with the vial coupling member cavity and the cavity. The vial coupling member cavity, the cavity, the first lumen, and the second lumen may form a sterile environment that is sealed from contaminants in an ambient environment. The apparatus may include a disengaging member configured to permit the container to disengage from the first fluid pathway and the second fluid pathway while permanently sealing at least one of the first lumen or the second lumen.

An infusion pouch set with a built-in injection medicine bottle having a vial function including: a discharge port 20 provided at an outlet 12 of a pouch container 10; and an injection port 30 provided at an inlet 14 of the pouch container 10; wherein the injection port 30 comprises, an injection needle part 40 configured to have an injection needle 44 provided vertically on an upper part of an injection needle holder 42 which is welded to the inlet 14 of the pouch container 10; an inner cap 50 having a sealing membrane 52 which is coupled to the injection needle holder 42 of the injection needle part 40, accommodates the injection needle 44 therein, and is punctured by the injection needle 44 when lowered; an outer cap 60 which is vertically moveable along the same axis as the inner cap 50 and accommodates an injection medicine bottle 70 in an upside down state therein; and a packing holder 90 which is vertically movably coupled at an upper part of the sealing membrane 52 of the inner cap 50, and a lower part of the packing holder 90 accommodates a packing 80 which hermetically couples an inlet cover 72 with the sealing membrane 52 and has a vertical through-hole 82 at its center.

3.2

FIG. 7

The invention regards a vial adapter, comprising two chamber parts in axial extension of each other, wherein the first chamber part is con- figured for slidably receiving at least a part of the vial crown, and the second chamber part is configured for slidably receiving at least a part of the vial body, wherein the first chamber part andor the second chamber part comprises one

A system for closed transfer of fluids includes a vial adapter having a body with a first end and a second end, a vial connection extending from the second end of the body, with the vial connection configured to secure the body to a vial, a vial spike extending from the second end of the body, with the vial spike defining a passageway, and a collet connection extending from the first end of the body. The system further includes a syringe adapter including a housing having a first end and a second end, a membrane housing positioned within the housing, with the membrane housing moveable between a first position and a second position, a cannula positioned within the housing, and a syringe connection extending from the first end of the housing, with the syringe connection configured to be secured to a syringe barrel.