A connection assembly configured to deliver a medical liquid to a container is described. The connection assembly includes a connecting member connected to the container, an attachment member, and a sealing element. The attachment member defines a lumen, a first end to be connected to a delivery device, and a second end connected to the connecting member. The sealing element is disposed in the lumen of the attachment member and includes a sealing head, a flange, and a foot portion. The sealing head seals the lumen of the attachment member, and the flange and the foot portion engage the connecting member.

A cannula for a vial adapter, having a pressure equalization device, includes a body having a first end, a second end positioned opposite the first end, and a sidewall extending between the first end and the second end. The body defines a central passageway extending from the first end to the second end of the body, with the body defining an opening extending through the sidewall of the body. The opening is in fluid communication with the central passageway. The second end of the body is closed.

A syringe adapter is provided. The adapter includes a housing having a first end and a second end positioned opposite the first end. The first end of the housing has a connector configured to be secured to a syringe barrel. The adapter also includes a cannula positioned within the housing and a seal arrangement including a membrane or septum positioned within the housing and movable within the housing, the seal arrangement comprising a membrane. The assembly can also include a protective cap having a first open end and a second closed end. The protective cap can be connected to the housing via a snap fit and can be configured to receive the second end of the housing.

An intravenous fluid bag comprising: a primary chamber configured to retain a liquid; a valve in fluid communication with the primary chamber, the valve including a housing, a spike element, and a seal, with the housing surrounding the seal, which surrounds the spike element; the spike element having a first end culminating in a tip, a second end having an inner conduit, and one or more through holes between the tip and the second end in fluid communication with the inner conduit forming part of a continuous liquid passageway in fluid communication with the primary chamber; the seal having a relaxed state preventing fluid flow through the valve, and the seal having a compressed state through which the through holes of the spike element extend allowing fluid flow from a source external the intravenous fluid bag, through the through holes, through the inner conduit, and into the primary chamber.

A valve is disclosed, the valve comprising a housing having an first opening and a second opening, and an elastomeric member positioned in the housing, the elastomeric member comprising a thickness, a continuous peripheral wall projecting from the thickness, and a slit extending through the thickness, a continuous portion of the peripheral wall creating a continuous sealable contact with the housing and partitioning the housing into an upper section and a lower section, the elastomeric member configured such that upon creating a pressure differential between the upper section and the lower section of the housing causes either: (i) the peripheral wall to deflect from the housing permitting fluid flow around the elastomeric member; or (ii) the slit to open permitting fluid flow through the elastomeric member. Methods using the valve are also disclosed.

A container for a medical liquid, comprising a connection piece via which a medical liquid can be pumped into or out of the container, an attachment part which can be attached to the connection piece and connected to a pump device to pump a medical liquid or out of the container, and a sealing element for sealing a passage between the connection piece and the attachment part. The sealing element has a slot opening which is closed against a liquid flow when the pump device is not attached to the attachment part and which is open when the pump device is attached to the attachment part such that a medical liquid can be pumped through the slot opening. The attachment part has a connection portion with an opening into which the connection piece can be inserted along an insertion direction in order to connect to the attachment part.

A cap assembly includes an access member configured for attachment to a reservoir. The access member includes a first port that enables needleless extraction of contents from the reservoir, and at least one second port that enables needled extraction of the contents from the reservoir. The cap assembly further includes a valve member positioned in or configured to be positioned in the access member to i) enable needleless extraction of the contents of the reservoir through the first port when the first port is attached to a needless extraction device, ii) enable needled extraction of the contents through the at least one second port, and iii) seal the contents of the reservoir at the first port and at the at least one second port prior to and subsequent to the needleless or needled extraction.

Hydrogel fracturing devices are described herein that include a chamber with an inlet, outlet, and at least one fracturing structure which extends across the entire internal diameter of the chamber. The fracturing structure includes one or more apertures or screens. The fracturing device may be connected to a syringe and/or ampoule containing a hydrogel formulation. The hydrogel formulation may then be fractured by forcing the formulation through the fracturing device.

A liquid-transfer adapter operatively interposable between an injector and a vial is provided. The liquid-transfer has an injector engaging portion configured for fluidly coupling to an injector and a vial coupling. The vial coupling includes a spike that has a spike axis and a tip portion configured for piercing a septum of a vial. The tip portion includes a plurality of facets that meet each other at one or more edges and at least one of the one or more edges is sloped with respect to the spike axis. The spike defines a channel extending therethrough in fluid communication with the injector engaging portion. A channel opening is defined in at least one of the facets and disposed without interrupting the edges.

Liquid transfer devices based on commonly owned WIPO International Publication No. WO 2007/052252 entitled Needleless Additive Control Valve. The liquid transfer devices include either an integral vial adapter and/or an integral infusion set for reducing cost and facilitating use by reducing user steps.