A drum coater device (10) for coating tablets, comprising a mixing drum (18) which can be rotated about an axis of rotation (20) and which has an interior (24) for arranging a tablet batch to be coated, further comprising a spraying device for introducing a coating material into the interior, wherein the mixing drum has a hollow-cylindrical, perforated wall which delimits at least part of the interior of the mixing drum, wherein mixing elements for mixing the tablets of a tablet batch are arranged on the inner side, which faces the interior, of the wall, wherein pairs (36) of mixing elements (34a, 34b) form legs which are oriented with respect to one another in a V shape, wherein the distance between the legs of a pair widens from a central annular region, as seen along the axis of rotation, of the wall in the direction of lateral annular regions adjacent to the central annular region.

A medicament delivery product is provided in which one or more medicaments are fixed on a sheet according to a patient-specific pre-defined pattern. The sheet is formed into a three-dimensional or non-planar shape to facilitate ingestion by the patient. The pre-defined patterns for the medicaments are configured for controlled release or absorption of the corresponding medicament after ingestion by the patient. The medicaments can be in a liquid or a powder form and applied to the surface of the sheet in an appropriate manner. The one or more medicaments can be any combination of drugs, medicines, vitamins, nutritional supplements and the like.

A coating apparatus and a method are disclosed for coating tablets in a rotating drilled container at the outlet of which a rotating annular element operates that is coaxial with the container, in which in an initial transition phase the annular element rotates in a direction that is opposite the rotation direction of the container to retain the tablets inside the container, forming a bed of tablets until a desired level is reached, and in a stationary phase the annular element rotates in a direction that is the same as the rotation of the container to permit the exit of the tablets, until the quantity of tablets entering the container is the same that the quantity exiting.

The present disclosure discloses a method for preparing an anti-hepatoma drug sanjie tablet, which includes a sanjie tablet containing components of Typhonii Rhizoma, exocarp of Juglans mandshurica, Dictamni Cortex and Bovis Calculus Artifactus. The preparation method includes the steps of: step 1. removing toxins from the components of Typhonii Rhizoma, exocarp of Juglans mandshurica and Dictamni Cortex in the sanjie tablet to obtain powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex; and step 2, uniformly mixing the powder of nontoxic Typhonii Rhizoma, nontoxic exocarp of Juglans mandshurica, and nontoxic Dictamni Cortex obtained in step 1 with Bovis Calculus Artifactus, granulating with a volatile medium, drying, tabletting, and conducting film-coating to obtain the sanjie tablet. Beneficial effects: the components in the composition of the sanjie tablet is decomposed and transformed by probiotics, and improving the medication safety of a patient in clinic.

The present invention relates to a tablet composition comprising a granulate consisting of a co-precipitate on a substrate, wherein the co-precipitate comprises enzalutamide in amorphous form and a cellulosic concentration enhancing polymer. The invention further relates to the use of said composition as a medicament, particularly in the treatment of castration-resistant prostate cancer.

The invention provides a solid-dosage-form printing apparatus comprising: i) a 3D printer suitable for printing solid-dosage-forms, said 3D printer comprising an interchangeable print head selected from the group consisting of: a fused deposition modelling print head, a semi-solid extrusion print head and a direct powder extrusion print head; ii) a build platform; iii) a balance for measuring the mass of the printed solid-dosage-forms, said balance being integrated into said build platform; and optionally iv) means for performing in-line near-infra-red and/or raman spectroscopy on the solid-dosage-form product; wherein said solid-dosage-form comprises at least one active-ingredient and at least one excipient. Further provided are methods of producing solid-dosage-forms using the apparatus, including computer-implemented methods.

A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm.sup.2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

In an apparatus and method of manufacturing a multi-column multi-medicine oral dissolving film according to the present invention, all processes from film feeding, medicine coating, and medicine drying to product packaging are implemented as continuous automation processes, and under the automation processes, different kinds of medicines are coated on a base film in multiple columns in a signal layer by using a plurality of nozzles supplied with the different kinds of medicines, so that it is possible to improve productivity through the automation processes, to ensure product quality due to efficiency during drying caused by maintaining the thickness of the product, and to provide a convenience in the case of taking various kinds of small-amount medicines at one time or in the case of separately and selectively taking different kinds of medicines.

Disclosed are methods and apparatuses for manufacturing a solid formulation for oral administration, comprising an edible substrate portion on which a composition comprising a first pharmaceutical active ingredient is deposited, and solid formulations made thereby. The methods comprise providing an edible substrate in the form of a film comprising a plurality of portions, spraying a liquid formulation comprising the active ingredient and a solvent onto an edible substrate portion and evaporating the solvent to form a solid composition deposited on the edible substrate portion; measuring the quantity of active ingredient supported by the edible substrate portion and comparing to a predetermined value, and dividing the edible substrate into the plurality of portions.