Many drug therapies could be greatly improved by dosage forms that reside in the stomach for prolonged time and release the drug slowly. In this specification, therefore, a gastroretentive structured dosage form is disclosed. The dosage form comprises a solid core having at least a fluid-absorptive first excipient. The dosage form further comprises a semi-permeable surface layer substantially encapsulating said solid core. The surface layer comprises at least a mechanically strengthening second excipient. Upon ingestion, the surface layer-supported solid core expands with physiological fluid absorption and remains in the stomach for prolonged time.

Disclosed are methods, materials and devices that pertain to a microstirring pill technology with built-in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. In some aspects, a drug delivery device includes a pill matrix dissolvable in a fluid medium and loaded with a plurality of drug payloads; and a plurality of micro stirrers embedded in the pill matrix and configured to create a local fluid transport upon interacting with a biological fluid surrounding the microstirring pill.

Disclosed are methods, materials and devices that pertain to a microstirring pill technology with built-in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. In some aspects, a drug delivery device includes a pill matrix dissolvable in a fluid medium and loaded with a plurality of drug payloads; and a plurality of micro stirrers embedded in the pill matrix and configured to create a local fluid transport upon interacting with a biological fluid surrounding the microstirring pill.

A system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D printing. The system comprises a 3D printing machine (2) with a mechanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the mechanical system and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for holding a cartridge (28). Printing is done at formatted print locations (49) on the base (6). A method for producing pharmaceutical objects by providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, establishing a fluid connection between a cartridge and a print head, moving the print head nozzle according to a program and dispensing the pharmaceutical substance to a print base.

A pharmaceutical delivery device, comprising a cylindrical body formed from a plurality of concentrically arranged layers, each layer being formed from a biodegradable material and incorporating at least one active pharmaceutical agent. Optionally, the device comprises an outer layer, and inner layer and one or more intermediate layers, wherein at least one of the one or more intermediate layers is formed from a material having a greater rate of degradation that the inner and outer layers such that the inner and outer layers separate in use.

A medicament delivery product is provided in which one or more medicaments are fixed on a sheet according to a patient-specific pre-defined pattern. The sheet is formed into a three-dimensional or non-planar shape to facilitate ingestion by the patient. The pre-defined patterns for the medicaments are configured for controlled release or absorption of the corresponding medicament after ingestion by the patient. The medicaments can be in a liquid or a powder form and applied to the surface of the sheet in an appropriate manner. The one or more medicaments can be any combination of drugs, medicines, vitamins, nutritional supplements and the like.

A medicament delivery product is provided in which one or more medicaments are fixed on a sheet according to a patient-specific pre-defined pattern. The sheet is formed into a three-dimensional or non-planar shape to facilitate ingestion by the patient. The pre-defined patterns for the medicaments are configured for controlled release or absorption of the corresponding medicament after ingestion by the patient. The medicaments can be in a liquid or a powder form and applied to the surface of the sheet in an appropriate manner. The one or more medicaments can be any combination of drugs, medicines, vitamins, nutritional supplements and the like.

A coating apparatus and a method are disclosed for coating tablets in a rotating drilled container at the outlet of which a rotating annular element operates that is coaxial with the container, in which in an initial transition phase the annular element rotates in a direction that is opposite the rotation direction of the container to retain the tablets inside the container, forming a bed of tablets until a desired level is reached, and in a stationary phase the annular element rotates in a direction that is the same as the rotation of the container to permit the exit of the tablets, until the quantity of tablets entering the container is the same that the quantity exiting.

This patent includes a method for utilizing imaging biomarkers to improve pharmacologic dosing strategies. Specifically, biomarker specific CT and MM examination protocols are disclosed. Dose adjustments based on imaging biomarkers are discussed. Longitudinal analysis of imaging biomarkers is disclosed assess effectiveness of pharmacotherapy and dosing strategies thereof. Finally, manufacturing of a combination pill with day-to-day variations of drug quantities is disclosed.

This patent includes a method for utilizing imaging biomarkers to improve pharmacologic dosing strategies. Specifically, biomarker specific CT and MM examination protocols are disclosed. Dose adjustments based on imaging biomarkers are discussed. Longitudinal analysis of imaging biomarkers is disclosed assess effectiveness of pharmacotherapy and dosing strategies thereof. Finally, manufacturing of a combination pill with day-to-day variations of drug quantities is disclosed.