A capsule sealing system comprising: a heating unit for mounting on a capsule filling machine and receiving therein a plurality of filled capsules (FC) from the capsule filling machine, the heating unit comprising a first plate and a second plate spaced apart from each other by at least one biasing means, each plate having a plurality of grooves forming a plurality of circular holes between the plates when abutted to each other against the biasing means, to capture and heat seal each capsule; and an engaging mechanism for abutting the first and second plates against the biasing means.

The present invention relates to a device for dispensing a single droplet of a fluid, for example a single droplet of an adhesive, onto the inside surface of a cap or onto the inside surface of a body of a capsule, this is useful for rendering a closed capsule with a telescopically engaged cap and body more tamperproof, or for fixing a cap or a body or both, which encloses a caplet or tablet or a part thereof, to the caplet or the tablet.

A method of filling two piece hard shell capsules from top through opening on the center of domes of fused hard shell—FETH capsules, rather than open the “prelock” capsules and filling liquid into the body part of the hard shell capsules. The novel method will (i) significantly reduce the size of air bubbles, (ii) eliminate need for post filling banding or sealing, (iii) able to use any type of two piece hard shell capsules, eliminate the need for specially designed liquid fill friendly capsule and (iv) streamlined the traditional liquid filling process and make it into one continuous process. The capsules filled by the new methods hold 10-15% more liquid and become more competitive to soft gel capsules in terms of costs and efficiency.

Low dose pharmaceutical formulations may be prepared to deliver consistent low doses of a variety of pharmaceuticals with minimal additives. In particular, the low dose pharmaceutical formulations are solid unit dosage forms of low dose drug substances which may be prepared by a method that provides content uniformity across prepared solid unit dosage forms.

A capsule closure device is for closing two-piece capsules each having a capsule upper portion and a capsule lower portion. The capsule closure device includes a capsule upper portion receiving member and a capsule lower portion receiving member. The capsule upper portion receiving member has a receiving hole and an introduction hole which is arranged coaxially relative to the receiving hole. The capsule upper portion receiving member has at the inner side thereof between the receiving hole and the introduction hole a support shoulder for supporting the capsule upper portion. The capsule upper portion receiving member has at the inner side thereof at the introduction hole at least one ventilation hole.

Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.

An apparatus for aseptic sealing a capsule having coaxial parts that at least partly overlap when telescopically joined, certain embodiments of the apparatus comprising: a capsule carrier assembly provided with at least one cavity for accommodating a respective capsule therein; a clamping member comprising a first half and a second half disposed on either side of the cavity at a capsule processing station, and each half arranged to linearly displace towards the cavity containing the capsule to a clamped position over and/or around at least a portion of the capsule; wherein the clamping member comprises a sealing means adapted to apply a sealing fluid uniformly to a circumferential gap around the capsule to be sealed when in the clamped position, and wherein the clamping member further comprises a suction means adapted to provide an area of low pressure around the capsule after application of the sealing fluid so as to remove any excess sealing fluid from the capsule when in the same clamped position.

Present invention relates to a capsule sealing composition and the method of using said composition for sealing capsules. Said sealing composition contains an acidic or alkaline solute and a volatile solvent; said sealing method uses the characteristics of capillary action ad volatile solvents to dissolve and seal the junction of the capsule cover and capsule body and said capsule then becomes a sealed capsule and the drugs contained in the capsule will not leak easily.

Exemplary embodiments of the disclosure may be drawn to ingestible delivery devices. An ingestible delivery device may include a first compartment and a second compartment. A lipase may be contained within the first compartment, and a fat may be contained within the second compartment. The first compartment may be sealed from the second compartment prior to exposure to a trigger, preventing the lipase and the fat from contacting each other, and at least one of the first compartment or the second compartment may at least partially rupture upon exposure to the trigger, allowing the lipase and the fat to contact each other.

A tamperproof dosage form article comprising: a core, wherein the core comprises a first end and a second end; a first shell on at least a portion of the first end of the core; a second shell on at least a portion of the second end of the core; wherein the first and second shells comprise one or more locking protrusions extending along at least a portion of the circumference and inner surface of the shells, and the core comprises one or more locking recesses, and wherein at least a portion of the shells proximal to the locking protrusions is elastically deformable and arranged such that each one locking protrusion is snapped into each one of the locking recesses once inserted over a predetermined portion of the core to provide a locking force between the core and the shells.