A dispenser (100, 500, 900) for granules is disclosed herein. In a specific embodiment, the dispenser comprises a granular reservoir (1); a selector disk comprising (a) a feeder disk (2, 22, 52) comprising at least one protruding member (3, 23); and (b) a dispensing disk (8, 58) arranged to rotate in concert with the feeder disk (2, 22, 52). The dispensing disk further comprises at least one dispensing aperture (9) and a non-dispensing portion (103), the at least one dispensing aperture (9) being in registration with the at least one protruding member (3, 23). The dispenser (100, 500, 900) further comprises a holding disk (4, 94) comprising at least one through-hole (5) sandwiched between the feeder disk (2, 22, 52) and the dispensing disk (8, 58) and fixedly mounted with respect to the granular reservoir (1), wherein the selector disk is rotatable relative to the holding disk (4, 94) and the granular reservoir (1) between a first position in which the at least one protruding member (3, 23) is offset from the at least one through-hole (5) to allow a granule to be received from the granular reservoir and held within the at least one through-hole (5) by the non-dispensing portion (103) of the dispensing disk (8, 58) and a second position in which the at least one protruding member (3, 23) occludes the at least one through-hole (5) to allow the granule held in the at least one through-hole to dispense through the at least one dispensing aperture (9). Methods of dispensing granules using the dispenser (100, 500, 900) are also disclosed.

Various methods and apparatuses are presented for an ingestible capsule that includes a digital, ingestible sensor component—or ingestible sensor—embedded into the capsule. The ingestible sensor component may be configured to activate upon coming into contact with conductive fluid, such as a body's stomach fluid. Once activated, the ingestible sensor component may be configured to perform various tasks, such as transmitting one or more signals and obtaining biometric data about the body that ingested the capsule.

A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.

The present invention discloses a closing station (100) for a capsule filling machine comprising a bottom (110) and a top closing unit (120) configured to displace towards each other, such that bottom pins (112) associated with said bottom closing unit urge into through holes of a body holder (B) to contact closed ends of each filled capsule body sections (114) and sliding them into said open ends of each capsule cap sections (124), such that each capsule is partially closed against an exerting pre-compressive force of the top pins (122) and is completely closed when force against biasing means (130) of said top pins (122) is exerted for providing telescoping closing of the cap (124) and body (114) sections of each capsule.

A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multiphase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.

A weighing system is mounted on a support, and the support is configured to support the weighing system. The weighing system includes a feeding mechanism, a conveying and transferring mechanism, pushing rods, a pushing mechanism, resetting mechanisms, a weighing mechanism, and a linkage follower mechanism. The feeding mechanism is arranged at a top portion of the support. The conveying and transferring mechanism is arranged below the feeding mechanism. The conveying and transferring mechanism includes a transferring wheel, a plurality of first channels, a plurality of sliding blocks, a plurality of first grooves and a guide base. The pushing mechanism is arranged on one side of the transferring wheel. The resetting mechanisms are configured to push the sliding blocks connected with the pushing rods to slide along the first channel towards an initial direction, and the weighing mechanism is arranged below the transferring wheel.

The disclosure relates to a capsule filling machine for filling two-piece capsules that each include a capsule upper part and a capsule lower part. The capsule filling machine includes a measuring device, the measuring device including a capacitive measuring system. The measuring device is downstream of the closing station. The capacitive measuring system includes a measuring section, along which the mass of the filled, closed capsule can be measured via the capacitive measuring system. The measuring device includes a guide device for the closed capsule, the guide device being configured to convey the filled, closed capsule from the capsule segment to the measuring section of the capacitive measuring system.

A capsule mass measuring device includes conveyer roller 10 and measurement device 20 having measurement plate 30. Conveyer roller 10 is provided with protrusions 12 and accommodation parts 13 formed between adjacent protrusions 12, and each of which accommodating the capsule such that a longitudinal direction of the capsule is arranged along rotation axis 11a. Measurement plate 30 is provided with groove part 32 and the measurement plate is arranged such that the capsule in accommodation part 13 is supplied to groove part 32, by a rotation of the conveyer roller, during a period after the capsule passes through the lowest point until rotating 45 degrees, and the capsule of which the mass has been measured is discharged from measurement plate 30 by contacting one of protrusions 12, which is defined as one protrusion, due to the rotation of conveyer roller 10.

A comestible dosage form article for administration to a target subject, the dosage form comprising: an outer capsule comprising a first cap telescopically engageable with a first body; and an inner capsule, within the outer capsule, comprising a second cap telescopically engageable with a second body, wherein the inner capsule is inverted with respect to the outer capsule such that, in an assembled state, the second cap is proximal to the first body and distal to the first cap.

A feeding assembly to fill capsules with granules, in particular microgranules, has a filling drum, which is provided with a plurality of fillers, each defined by a respective suction pipe, which can be connected to a pneumatic sucking device and has a lower end to pick up/release the granules; the lower end of each suction pipe being closed by a closing element provided with a plurality of openings, each designed so as to prevent the granules from getting into the suction pipe.