Disclosed is a suppository comprising a suppository base. The suppository may have a length, relative to a horizontal axis, that is greater than its width, relative to a vertical axis. The suppository may have a proximal end and a distal end along the horizontal axis. The proximal end may be adapted for insertion into a body cavity. The distal end may have at least one indentation and adapted to be gripped, e.g., during manual insertion of the suppository into the body cavity.

Disclosed is a suppository comprising a suppository base. The suppository may have a length, relative to a horizontal axis, that is greater than its width, relative to a vertical axis. The suppository may have a proximal end and a distal end along the horizontal axis. The proximal end may be adapted for insertion into a body cavity. The distal end may have at least one indentation and adapted to be gripped, e.g., during manual insertion of the suppository into the body cavity.

The invention provides a solid-dosage-form printing apparatus comprising: i) a 3D printer suitable for printing solid-dosage-forms, said 3D printer comprising an interchangeable print head selected from the group consisting of: a fused deposition modelling print head, a semi-solid extrusion print head and a direct powder extrusion print head; ii) a build platform; iii) a balance for measuring the mass of the printed solid-dosage-forms, said balance being integrated into said build platform; and optionally iv) means for performing in-line near-infra-red and/or raman spectroscopy on the solid-dosage-form product; wherein said solid-dosage-form comprises at least one active-ingredient and at least one excipient. Further provided are methods of producing solid-dosage-forms using the apparatus, including computer-implemented methods.

The invention provides a solid-dosage-form printing apparatus comprising: i) a 3D printer suitable for printing solid-dosage-forms, said 3D printer comprising an interchangeable print head selected from the group consisting of: a fused deposition modelling print head, a semi-solid extrusion print head and a direct powder extrusion print head; ii) a build platform; iii) a balance for measuring the mass of the printed solid-dosage-forms, said balance being integrated into said build platform; and optionally iv) means for performing in-line near-infra-red and/or raman spectroscopy on the solid-dosage-form product; wherein said solid-dosage-form comprises at least one active-ingredient and at least one excipient. Further provided are methods of producing solid-dosage-forms using the apparatus, including computer-implemented methods.

A medicine dispensing system includes canisters and packing assemblies to place specific doses of medicines into capsules. The system removes inert and filler ingredients to place only those active ingredients prescribed to the patient. The system includes a conveyor belt to move the capsules between canisters filled with the active ingredients. A dose is placed and packed into the capsules for each active ingredient. Thus, the number of capsules for a variety of medicines is reduced.

A medicine dispensing system includes canisters and packing assemblies to place specific doses of medicines into capsules. The system removes inert and filler ingredients to place only those active ingredients prescribed to the patient. The system includes a conveyor belt to move the capsules between canisters filled with the active ingredients. A dose is placed and packed into the capsules for each active ingredient. Thus, the number of capsules for a variety of medicines is reduced.

In a method and a corresponding device for producing an extrudate, starting products are introduced into an extrusion container, heated, and homogeneously intermixed by dual asymmetric centrifugation of the extrusion container. The extrusion container is rotated about a primary rotation axis that extends outside the extrusion container, and is simultaneously rotated about a secondary rotation axis that extends through the extrusion container and is situated at an acute angle with respect to the primary rotation axis. Lastly, the intermixed starting products are jointly extruded from the extrusion container. The method and the corresponding device are particularly suitable for processing small and very small substance quantities.

Today's suppositories are typically packaged individually for digital administration into the anal canal of a patient. A suppository applicator described herein, which works with individually packaged suppositories, can alternatively be shipped in a prepackaged operational arrangement with a suppository to enable the patient to administer the suppository through use of the applicator in a single operation after opening a hygienic wrapper containing the applicator-suppository combination. A method for manufacturing a suppository includes manufacturing the suppository in the presence of and in contact with an element configured to be used to insert the suppository into a body cavity. The method may include using the element to define a shape of the suppository during the manufacturing. The resulting applicator-suppository combination is more hygienic and easier to handle than the separate applicator and suppository and provides more efficiency from time of opening the packaging to time of commencing administration of the suppository.

Today's suppositories are typically packaged individually for digital administration into the anal canal of a patient. A suppository applicator described herein, which works with individually packaged suppositories, can alternatively be shipped in a prepackaged operational arrangement with a suppository to enable the patient to administer the suppository through use of the applicator in a single operation after opening a hygienic wrapper containing the applicator-suppository combination. A method for manufacturing a suppository includes manufacturing the suppository in the presence of and in contact with an element configured to be used to insert the suppository into a body cavity. The method may include using the element to define a shape of the suppository during the manufacturing. The resulting applicator-suppository combination is more hygienic and easier to handle than the separate applicator and suppository and provides more efficiency from time of opening the packaging to time of commencing administration of the suppository.

A latching mechanism suitable for suppository molds, where the latching mechanism is designed to assist the separation of mold when the latch is released. In embodiments, the latching mechanism has a lever portion on a first mold half and a catch portion on a second mold half. The lever portion is configured to impinge upon the catch portion to provide a force to bias the first mold half away from the second mold half. Other embodiments include methods of utilizing such a catching mechanism with a suppository mold.