The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.

The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.

The present invention relates to a pharmaceutical composition, which is characterized in that the composition comprises an effective amount of proanthocyanidin, the monomer units of the proanthocyanidin have the chemical formula of formula (I), and a pharmaceutically acceptable carrier or salt; wherein the proanthocyanidin is a polymeric proathocyanidin with a degree of polymerization ranging from 50-65. It has good antioxidant stress and can be used to treat or prevent brain diseases and aging-related diseases caused by excessive production of ROS, or to prevent and treat aging. It can also be used for the treatment and prevention of liver disease, tumor, sarcopenia and other diseases.

The present invention relates to a pharmaceutical composition, which is characterized in that the composition comprises an effective amount of proanthocyanidin, the monomer units of the proanthocyanidin have the chemical formula of formula (I), and a pharmaceutically acceptable carrier or salt; wherein the proanthocyanidin is a polymeric proathocyanidin with a degree of polymerization ranging from 50-65. It has good antioxidant stress and can be used to treat or prevent brain diseases and aging-related diseases caused by excessive production of ROS, or to prevent and treat aging. It can also be used for the treatment and prevention of liver disease, tumor, sarcopenia and other diseases.

Compositions and methods for making and using a water soluble melanin, eumelanin, pheomelanin, allomelanin and DHN-melanin pigment produced from a fungus. The water soluble melanin can be used in a radioprotective composition having at least 0.1 to at least 8.0% (wt./vol.) melanin(s), a solvent and optionally a binder(s) and/or an additive(s). The aqueous soluble melanin has uses in medical, aeronautical, industrial, cosmetic and other applications that are disclosed.

Compositions and methods for making and using a water soluble melanin, eumelanin, pheomelanin, allomelanin and DHN-melanin pigment produced from a fungus. The water soluble melanin can be used in a radioprotective composition having at least 0.1 to at least 8.0% (wt./vol.) melanin(s), a solvent and optionally a binder(s) and/or an additive(s). The aqueous soluble melanin has uses in medical, aeronautical, industrial, cosmetic and other applications that are disclosed.

The present invention relates to a condensation product obtainable by reaction of a1) at least one aromatic system or heteroaromatic system, a2) at least one carbonyl compound, a3) if appropriate at least one sulfonating agent, and a4) if appropriate at least one urea derivative, where the condensation product has a molecular weight Mw of at least 300 g/mol, for use in a method for the treatment of COVID-19. The invention further relates to a use of the condensation product in a therapeutic method for the treatment of COVID-19; to a use of the condensation product as disinfectant against the virus SARS-CoV-2; and to a use of the condensation product for the production of a medicament which is an antiviral agent against SARS-CoV-2.

Provided are aqueous lignin solutions containing lignin solvated in Good's Buffers. The aqueous lignin solutions can be used in a variety of applications including biomedical research and in manufacturing a variety of lignin containing products including food grade and biomedical products. The aqueous lignin solutions can also be used in the treatment of microbial infection, as an adjuvant in antimicrobial therapeutics or therapy, and in forming antimicrobial products. Methods of making and using aqueous lignin solutions are also described.

Provided are aqueous lignin solutions containing lignin solvated in Good's Buffers. The aqueous lignin solutions can be used in a variety of applications including biomedical research and in manufacturing a variety of lignin containing products including food grade and biomedical products. The aqueous lignin solutions can also be used in the treatment of microbial infection, as an adjuvant in antimicrobial therapeutics or therapy, and in forming antimicrobial products. Methods of making and using aqueous lignin solutions are also described.

A topical ocular solution for treating or preventing age related macular degeneration (ARMD) comprising of one or more antioxidants and at least one pharmaceutically acceptable excipient, wherein the antioxidant is a carotenoid selected from lutein, zeaxanthin or antioxidants like alpha tocopherol and antioxidants of mineral origin like selenium or a combination thereof. An ophthalmic solution of antioxidant for treating or preventing age related macular degeneration (ARMD) comprising of one or more antioxidants, a surfactant/solubilizing agent, additionally at least one pharmaceutically acceptable excipient selected from the group comprising of a pH adjusting agent, a buffering agent, a osmolarity control agent and a preservative, wherein the ophthalmic solution has a pH range of 4 to 8.