The Invention relates to a fermented onion composition having a dry matter content of at least 8 wt. %, said composition comprising, per gram of dry matter: a) 0-150 mg of saccharides selected from fructose, glucose, sucrose and combinations thereof; b) 5-250 mg of phenols selected from acid equivalent of gallic acid, acid equivalent of ferulic acid, quercetin, kaempferol and combinations thereof; c) 75-500 mg acid equivalent of organic acid selected from propionic acid, lactic acid, acetic acid and combinations thereof, including at least 200 mg lactic acid equivalent and/or at least 75 mg propionic acid equivalent and/or at least 120 mg acetic acid equivalent; wherein the combination of components a) to c) constitutes 50-89 wt. % of the dry matter that is contained in the composition; and wherein at least 90 wt. % of the composition is dissolved at a temperature of 20° C. when the composition is diluted with distilled water to a dry matter content of 5 wt. %.

The fermented onion composition of the present invention can advantageously be used as an effective, label friendly food ingredient to increase overall quality of foods.

The invention also provides a method of preparing a fermented onion composition, comprising: providing an onion substrate containing 10-50 wt. % dry matter and 50-90 wt. % water, wherein at least 40 wt. % of the dry matter is derived from onion; inoculating the substrate with a micro-organism selected from lactic acid producing bacteria, Propionibacterium, acetic acid producing bacteria and combinations thereof; and incubating the inoculated substrate at a temperature in the range of 25-60° C. for at least 12 hours to produce an onion ferment.

The invention provides topical pharmaceutical gel compositions for the treatment of chronic skin damage, specifically for damage caused by neuropathic ulcers and preferably for the treatment of diabetic foot, and in the treatment of vascular ulcers wherein said compositions comprise a combination of Modified Diallyl Disulfide Oxide (M-DDO) (as an antiseptic/antibiotic agent) and 5-methyl-1-phenyl-2(1H)-pyridone. Furthermore, the invention describes methods of treatment, applications and/or pharmaceutical uses in the preparation of medicaments for eliminating, reducing or preventing chronic skin lesions and the damages caused by neuropathic ulcers and particularly in the treatment of diabetic foot and in the treatment of vascular ulcers.

The present invention relates to nutritional supplements for the human diet used to manipulate HDL cholesterol, LDL cholesterol, and triglyceride levels in human blood plasma. The invention contains a novel combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) present in Fish Oil, alpha-linolenic acid (ALA) present in Flaxseed Oil, Vitamin E in the form of d-alpha-tocopherol, Allicin present in Garlic, Phosphatidylcholine present in Lecithin, plant phytochemicals present in Parsley herb, citrus flavonoids present in Lemon fruit and Rutin (from Sophora japonica), and Capsaicin present in Cayenne Pepper.

The present invention relates to nutritional supplements for the human diet used to manipulate HDL cholesterol, LDL cholesterol, and triglyceride levels in human blood plasma. The invention contains a novel combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) present in Fish Oil, alpha-linolenic acid (ALA) present in Flaxseed Oil, Vitamin E in the form of d-alpha-tocopherol, Allicin present in Garlic, Phosphatidylcholine present in Lecithin, plant phytochemicals present in Parsley herb, citrus flavonoids present in Lemon fruit and Rutin (from Sophora japonica), and Capsaicin present in Cayenne Pepper.

Oral compositions comprising cinnamaldehyde, and methods or improving circulation and improving circulation by administering such compositions, are described. Methods and uses are describe that include the administration of an effective amount of the oral compositions to improve circulation and increasing nerve sensitization, while also resulting in improved balance, and reduced pain, numbness, and/or tingling in the hands and feet, as well as reduced restlessness, fatigue, and tiredness of the legs.

Oral compositions comprising cinnamaldehyde, and methods or improving circulation and improving circulation by administering such compositions, are described. Methods and uses are describe that include the administration of an effective amount of the oral compositions to improve circulation and increasing nerve sensitization, while also resulting in improved balance, and reduced pain, numbness, and/or tingling in the hands and feet, as well as reduced restlessness, fatigue, and tiredness of the legs.

An oral pharmabiotic system is disclosed for improving oral, dental, and systemic health by repopulating and reshaping the flora within a patient's oral environment in a manner that overcomes the deficiencies of prior oral probiotic products. By formulating the pharmabiotic system as a strip for adhesive placement within a patients' oral cavity, preferably against the buccal mucosa, alveolar mucosa, oral labial mucosa, or a dental appliance, and configuring the parameters of the strip such that neither disadhesion nor complete dissolution occurs for at least a period of at least three hours during daytime use and at least six hours during nighttime use, the probiotic payload contained within may remain in the oral cavity for a sufficient length of time required for the probiotics to activate, replicate, and displace existing harmful oral pathobiotics.

An oral pharmabiotic system is disclosed for improving oral, dental, and systemic health by repopulating and reshaping the flora within a patient's oral environment in a manner that overcomes the deficiencies of prior oral probiotic products. By formulating the pharmabiotic system as a strip for adhesive placement within a patients' oral cavity, preferably against the buccal mucosa, alveolar mucosa, oral labial mucosa, or a dental appliance, and configuring the parameters of the strip such that neither disadhesion nor complete dissolution occurs for at least a period of at least three hours during daytime use and at least six hours during nighttime use, the probiotic payload contained within may remain in the oral cavity for a sufficient length of time required for the probiotics to activate, replicate, and displace existing harmful oral pathobiotics.

The present invention relates to a composition for oral use comprising at least an extract of red yeast rice, at least an extract of a plant belonging to the genus Allium and at least an extract of a plant belonging to the genus Malus and to the use thereof for the prevention and/or treatment of hypercholesterolemia, the main cardiovascular risk factor.

The present invention relates to a composition for oral use comprising at least an extract of red yeast rice, at least an extract of a plant belonging to the genus Allium and at least an extract of a plant belonging to the genus Malus and to the use thereof for the prevention and/or treatment of hypercholesterolemia, the main cardiovascular risk factor.