The present invention relates to a Chinese herbal medicine composition which is prepared from a raw material comprising the following ratio: 1 part by weight of Lilium brownii var. viridulum, 5 parts by weight of Houttuynia cordata, 2 parts by weight of Atractylodes macrocephala, 2 parts by weight of Poria cocos(Schw.) Wolf., 1 part by weight of Ziziphi Spinosae Semen, 3 parts by weight of Adenophora morrisonensis, 2 parts by weight of Semen Astragali Complanati, 0.5 parts by weight of Zingiber officinale, 5 parts by weight of Tribulus terrestris, 3 parts by weight of Pogostemon cablin, 0.5 parts by weight of Ziziphus jujuba, and 0.1 parts by weight of Dimocarpus longan. The invention also relates to a method of using the herbal composition for inhibiting melanoma cell metastasis. The invention also relates to a process for the preparation of the herbal composition.

The present invention relates to a Chinese herbal medicine composition which is prepared from a raw material comprising the following ratio: 1 part by weight of Lilium brownii var. viridulum, 5 parts by weight of Houttuynia cordata, 2 parts by weight of Atractylodes macrocephala, 2 parts by weight of Poria cocos(Schw.) Wolf., 1 part by weight of Ziziphi Spinosae Semen, 3 parts by weight of Adenophora morrisonensis, 2 parts by weight of Semen Astragali Complanati, 0.5 parts by weight of Zingiber officinale, 5 parts by weight of Tribulus terrestris, 3 parts by weight of Pogostemon cablin, 0.5 parts by weight of Ziziphus jujuba, and 0.1 parts by weight of Dimocarpus longan. The invention also relates to a method of using the herbal composition for inhibiting melanoma cell metastasis. The invention also relates to a process for the preparation of the herbal composition.

The present invention relates to a Chinese herbal medicine composition which is prepared from a raw material comprising the following ratio: 1 part by weight of Lilium brownii var. viridulum, 5 parts by weight of Houttuynia cordata, 2 parts by weight of Atractylodes macrocephala, 2 parts by weight of Poria cocos(Schw.) Wolf., 1 part by weight of Ziziphi Spinosae Semen, 3 parts by weight of Adenophora morrisonensis, 2 parts by weight of Semen Astragali Complanati, 0.5 parts by weight of Zingiber officinale, 5 parts by weight of Tribulus terrestris, 3 parts by weight of Pogostemon cablin, 0.5 parts by weight of Ziziphus jujuba, and 0.1 parts by weight of Dimocarpus longan. The invention also relates to a method of using the herbal composition for inhibiting melanoma cell metastasis. The invention also relates to a process for the preparation of the herbal composition.

An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya, nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (Undaria pinnatifida), and mozuku (Nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (Grifola frondosa) and shiitake (Lentinus edodes).

An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, Japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (Japanese persimmon), papaya, nashi (Japanese pear), watermelon, ume (Japanese apricot), fig, karin (Chinese quince), pumpkin, kumquat, yuzu (Chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (Japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (Jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (Japanese yam), daikon (Japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (Korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (Undaria pinnatifida), and mozuku (Nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (Grifola frondosa) and shiitake (Lentinus edodes).

The present disclosure belongs to the technical field of health care products or foods and provides the use of a ginseng alcohol extract in sleep-promoting health care products or foods. Through analysis utilizing DAM2 drosophila behavior monitoring system, it is found that the ginseng alcohol extract can increase total sleep duration of normal and sleep deprived drosophilae, and relieve sleep rhythm disorder caused by sleep deprivation. Through a climbing experiment, it is found that the ginseng alcohol extract can improve the climbing ability of normal and sleep deprived drosophilae. The ginseng alcohol extract, on the one hand, improves the quality of sleep to protect the steady state of sleep rhythm, and on the other hand, increases the motive ability after sleep. The ginseng alcohol extract of the present disclosure is intended to be used to sleep-promoting health care products or healthy foods and improve the quality of sleep.

The present disclosure belongs to the technical field of health care products or foods and provides the use of a ginseng alcohol extract in sleep-promoting health care products or foods. Through analysis utilizing DAM2 drosophila behavior monitoring system, it is found that the ginseng alcohol extract can increase total sleep duration of normal and sleep deprived drosophilae, and relieve sleep rhythm disorder caused by sleep deprivation. Through a climbing experiment, it is found that the ginseng alcohol extract can improve the climbing ability of normal and sleep deprived drosophilae. The ginseng alcohol extract, on the one hand, improves the quality of sleep to protect the steady state of sleep rhythm, and on the other hand, increases the motive ability after sleep. The ginseng alcohol extract of the present disclosure is intended to be used to sleep-promoting health care products or healthy foods and improve the quality of sleep.

An extract of Lilium hansoni Leichtlin ex Baker, according to the present invention, exhibits a whitening effect by inhibiting the expression of tyrosinases and reducing the total amount of melanin, reduces wrinkles and improves skin elasticity by promoting collagen synthesis of fibroblasts in the skin and inhibiting the activity of collagenases, exhibits an effect of anti-glycation that inhibits glycation, exhibits a skin moisturization effect by promoting the synthesis of hyaluronic acid, exhibits an effect of improving skin texture by reducing skin roughness, and exhibits effects of irritation relief and relief of stinging, itching, burning sensations and the like, thereby being usable in the preparation of cosmetic products, pharmaceuticals and foods.

An extract of Lilium hansoni Leichtlin ex Baker, according to the present invention, exhibits a whitening effect by inhibiting the expression of tyrosinases and reducing the total amount of melanin, reduces wrinkles and improves skin elasticity by promoting collagen synthesis of fibroblasts in the skin and inhibiting the activity of collagenases, exhibits an effect of anti-glycation that inhibits glycation, exhibits a skin moisturization effect by promoting the synthesis of hyaluronic acid, exhibits an effect of improving skin texture by reducing skin roughness, and exhibits effects of irritation relief and relief of stinging, itching, burning sensations and the like, thereby being usable in the preparation of cosmetic products, pharmaceuticals and foods.

A process for the preparation of a plant extract enriched in polyphenols and/or substantially free of simple sugars, as well as the plant extract thus obtained, which may be added to a cosmetic composition. Also, the use of a yeast of the variety Saccharomyces cerevisiae var. bayanus for the removal of simple sugars in a plant extract.