The disclosure features pharmaceutical compositions formed from prodrug dimers for the extended delivery of a drug and for the treatment of a disease or condition.

A bone repair material, a preparation method of the bone repair material, and a biological composite scaffold are provided. The bone repair material includes: a base material, and a carbon nanomaterial and a polypeptide both mixed with the base material; and the carbon nanomaterial and the polypeptide are bonded by chemical bonds. The preparation method includes: bonding a carbon nanomaterial with a polypeptide by chemical bonds; and mixing the carbon nanomaterial and the polypeptide bonded by the chemical bonds with a base material, and performing a molding treatment.

The disclosure relates to compounds and compositions for sustained release of ocular therapeutics.

Provided herein are compositions and methods for targeted drug delivery to treat pulmonary injury. In particular, provided herein are nanoscale delivery vehicles for: drugs that treat pulmonary injury. Also provided here in are methods of generating the nanoscale delivery vehicles and compositions thereof.

Provided is a nanogel exhibiting anticoagulation and antioxidation activities, including a graphene-like nanosheet and a polysaccharide, which are complexed to form a cross-linked supramolecular structure. Also provided is a method of preparing the nanogel, including carbonizing the polysaccharide by dry heating. By the heating process, at least a portion of the polysaccharide is conversed into the graphene-like nanosheet, thereby forming a graphene-like nanosheet-embedded phenolic-polysaccharide nanogel that has exceptional polyphenolic structure and high binding affinity toward thrombin. Further provided is a method of preventing or treating a disease or a condition susceptible to amelioration by anticoagulants or antioxidants by using the nanogel.

Described herein are compositions in nanofiber form including one or more bioactive compounds releasably incorporated thereon. In one embodiment a composition is described comprising at least one nanofiber and at least one bioactive compound. The nanofibers are formed from a base material that is solubilized with the bioactive or bioactives in an aqueous based solvent solution and the base material and bioactives are together spun via electrospinning to form dry fibers with the bioactives chemically bonded to the nanofibers and the bioactives remaining stable during storage of the composition under ambient conditions substantially free of moisture. On exposure to moisture, the nanofibers dissolve, thereby releasing the bioactives.

Methods for functionalizing the surface of nanofiber substrates, including electrospun fibres and non-woven or woven mats of fibres are described. Functionalised nanofiber substrates presenting biologically active moieties such as biotin and saccharides are described.

Green-synthesized tellurium nanowires (GREEN-TeNWs) are generated using a biopolymer as a unique reducing agent, purified, and used as a template for the growth of coated palladium nanoparticles (PdNPs) and platinum nanoparticles (PtNPs) on top of the GREEN-TeNWs, in a reaction that can take place in seconds, with no need for high temperature, stirring, or for additional reducing agent. The heterogeneous structure can contain palladium oxide or platinum oxide. The green-synthesized PdNPs-TeNWs (palladium nanoparticles with tellurium nanowires) and PtNPs-TeNWs (platinum nanoparticles with tellurium nanowires) show potential biomedical applications as antibacterial, anticancer, and antioxidant agents, and show low cytotoxicity for healthy human cells.

A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor (TFRC) and/or receptor for advanced glycation end products (RAGE). The polypeptide conjugate may be used in a method for targeting of a drug delivery system or diagnostic delivery system.

The invention provides a composition and pharmaceutical formulation including a peptide immobilized in a hydro gel. Compositions and formulations of the invention are useful in reducing the size, severity or duration of a wound, ameliorating of one or more symptoms associated with a wound without necessarily curing the wound, or lessening in the growth or severity of a wound. Compositions and formulations of the invention are particularly useful in the treatment of a wound associated with diabetes, such as a diabetic ulcer.