Disclosed are methods of treating an aneurysm in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising a SELP. Disclosed are methods of preventing rupture of an aneurysm comprising administering to a subject having an aneurysm a composition comprising a SELP, wherein the SELP is present in the aneurysm and prevents rupture. Also disclosed are methods of embolizing an aneurysm in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising SEEP. Disclosed are methods of treating AVM in a subject comprising administering to the subject a composition comprising a SELP. In some aspects, the SELP embolizes an abnormal blood vessel in the AVM. Disclosed are methods of embolizing an AVM in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising a SELP, wherein the SELP embolizes an abnormal blood vessel in the AVM.

The present invention provides a hollow borosilicate microparticle contrast media for use in CT imaging with shell material containing less than 8% oxides of non-silicon elements with atomic number greater than 10. In an exemplary embodiment, the invention provides an enteric contrast medium formulation which provides CT numbers distinct from those of water, soft tissue, and fat. In an exemplary embodiment, the invention provides an enteric contrast medium formulation that shows iodine concentrations less than 1.0 mg iodine/mL at dual energy CT or multi-energy CT image reformations. An exemplary formulation comprises, (a) an enteric contrast medium comprising a hollow borosilicate microparticle suspended in water. Exemplary hollow borosilicate microparticle has a true gravity between 0.1 and 0.4 g/cm.sup.3. In various embodiments, the hollow borosilicate microparticle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspended. In an exemplary embodiment, the hollow borosilicate microparticle comprises 1% to 15% of the weight of an aqueous contrast material formulation. The invention also provides methods for imaging of the abdomen and pelvis by CT imaging contemporaneously with the delivery of the hollow borosilicate microparticle contrast material into the bowel lumen.

A radiographic imaging apparatus includes an imaging apparatus and a hardware processor. The imaging apparatus obtains moire fringe images for generating a reconstruction image of a subject by using a Talbot-Lau interferometer comprising a radiation source, a multiple slit, a first grating, a second grating and a radiation detector. The hardware processor performs a control to satisfy relations (i) φ≧(½)×(R.sub.S/R.sub.1)×d.sub.1>φ×0.7, (ii) 1≦φ≦10 (μm), and (iii) 0.5≦(R.sub.s/R.sub.1)≦1. φ is a particle size of a microbubble contrast agent to be used in imaging. d.sub.1 is a slit period of the first grating. R.sub.1 is a distance between the multiple slit and the first grating. R.sub.s is a distance between the multiple slit and the subject.

A radiopaque particulate material one or more of SiO.sub.2, TiO.sub.2, La.sub.2O.sub.3, Na.sub.2O and MgO and useful for embolization which optionally includes therapeutic components that are released in vivo.

This invention provides methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a “glue” to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species, which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material, which is already encapsulated.

A glass material that includes: from about 0.55 to about 0.85 mole fraction of SiO.sub.2; from about 0.01 to about 0.23 mole fraction of Na.sub.2O, K.sub.2O, or a combination of Na.sub.2O and K.sub.2O; from about 0.05 to about 0.28 mole fraction of: Y.sub.2O.sub.3, BaO, or a combination of Y.sub.2O.sub.3 and BaO; and optionally Ta.sub.2O.sub.5. In the glass material, the sum of the Y.sub.2O.sub.3, the BaO and the optional Ta.sub.2O.sub.5 is from about 0.10 to about 0.31 mole fraction. The glass material may be in the form of microspheres. The microspheres may be used for vascular embolization and/or radiologic imaging.

Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.

A radiology viewer includes an electronic processor (10, 22), a display (12), input device(s) (14, 16), and a non-transitory storage medium storing executable instructions. Retrieval instructions (42) are executable to retrieve an index of prior radiology examinations (24, 26) from an electronic patient chart (20) in which the prior radiology examinations are indexed by at least date, imaging modality, and anatomical region and to retrieve billable order codes for the prior radiology examinations from an order management system (30). Organizing instructions (44) are executable to organize the prior radiology examinations into groups using features of the prior radiology examinations including features comprising or generated from the billable order codes for the prior radiology examinations. Viewer instructions (50) are executable to display an organized index of the prior radiology examinations on the at least one display in which the prior radiology examinations are organized into the groups.

The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

Implantable materials may be used as spacers for separating tissues to reduce a dose of radioactivity received by one of the tissues. Applications include introducing a hydrogel spacer to a position between a first tissue location and a second tissue location to increase a distance between the first tissue location and the second tissue location, Further, there may be a step of administering a dose of radioactivity to at least the first tissue location or the second tissue location and/or a step of visualizing margins of the hydrogel spacer. A hydrogel spacer may comprise a polysaccharide and a radioopaque agent and may be used for fiducial marking.