The present invention relates to a structure for accelerating transdermal absorption, a manufacturing method thereof, and a cosmetic composition comprising the same, and the structure for accelerating transdermal absorption comprises an acicular body; a hydrophilic group binded to the acicular body; and a carrier binded to the hydrophilic group.

The present invention has an object to provide a skin anti-aging agent, an agent for regulating expression of anti-aging related gene, and a cosmetic product comprising the anti-aging agent or the agent for regulating expression of anti-aging related gene which are very safe and can be used reliably for a long term. The skin anti-aging agent, the agent for regulating expression of anti-aging related gene, and the cosmetic product comprising the anti-aging agent or the agent for regulating expression of anti-aging related gene of the present invention comprise a special low molecular DNA and a soybean extract, preferably a soybean sprout extract, as active ingredients. These active ingredients have activating actions on the function of the dermal fibroblast and are hence expected to prevent or improve the skin aging such as the reduction of skin firmness and elasticity, wrinkles and sagging.

The invention relates to a botulinum neurotoxin-encoding nucleic acid for therapeutic use. The invention further relates to the transfection of skeletal muscle cells and smooth muscle cells and the glands of the skin, and of other skin cells with botulinum neurotoxin (BoNT)-encoding nucleic acids (RNA or DNA) with or without the use of a secretory signal, for therapeutic and/or cosmetic purposes.

Peptide-based systems containing hydrophobic amino acids (e.g., tryptophan), charged amino acids (e.g., arginine), and/or sulfur-containing amino acids (e.g., cysteine), which can be used either alone or in combination with nanoparticles (e.g., gold or silver nanoparticles) for siRNA delivery into living cells are disclosed.

A cosmetic composition exerts a high improving effect on a texture of hair of a head or a scalp. The cosmetic composition includes nucleic acid, succinic acid, alanine, citric acid, and glycine. An amount of the nucleic acid is 6.6 to 11.5% by mass based on a total mass of the composition, and an amount of the citric acid is 7.1 to 17.4% by mass based on the total mass of the composition. The cosmetic composition is allowed to contain at least one member selected from, for example, histidine, arginine, proline, isoleucine, serine, valine, aspartic acid, threonine, phenylalanine, pyrrolidonecarboxylic acid, sodium pyrrolidonecarboxylate, sodium lactate, and water to prepare a cosmetic.

The present application provides a method for preparing a hydrogel and the obtained hydrogel. The method including: forming a first part by mixing a first single-stranded nucleotide with a first liposome, and forming a second part by mixing a second single-stranded nucleotide with a second liposome, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends; forming a hydrogel by mixing the first part and the second part.

The invention pertains to a cosmetic composition comprising NMN, a precursor thereof, a derivative thereof, against skin ageing.

Described herein are anti-microbial and UV-protective biological devices and extracts produced therefrom. The biological devices include microbial cells transformed with a DNA construct containing genes for producing proteins such as, for example, zinc-related protein/oxidase, silicatein, silaffin, and alcohol dehydrogenase. In some instances, the biological devices also include a gene for lipase. Methods for producing and using the devices are also described herein. Finally, compositions and methods for using the devices and extracts to kill microbial species or prevent microbial growth and to reduce or prevent UV-induced damage or exposure to materials, items, plants, and human and animal subjects are described herein. Also disclosed are biological devices producing polyactive carbohydrates and carbo sugars, as well as compositions and articles incorporating both extracts from these devices and the anti-microbial and UV-protective extracts.

In the case that an external skin agent that contains a specific component is to be applied to the skin of a right hand, a liquid that contains ultrafine bubbles is applied to the portion of the skin onto which the external skin agent is to be applied. The application of the liquid is performed prior to the external skin agent being applied, by spraying the liquid from an aerosol container having a spray actuator with a flow rate adjusting mechanism.

Topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and S-adenosyl-L-methionine. Use of niacinamide and S-adenosyl-L-methionine in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.