Disclosed are bolus compositions for ruminants comprising potassium phosphate dibasic and water configured to rapidly dissolve in the rumen for use in the prevention or treatment of hypokalemia and hypophosphatemia. These conditions occur in ruminants at around the time of calving or during periods when ruminants do not eat (anorexia). The bolus compositions may comprise a coating that is compatible with a ruminant digestive tract. Additionally, the bolus compositions may comprise a wick which may be used during the manufacturing process to facilitate the bulk handling and transfer of the bolus compositions.

The present invention includes an economic, synergistic, non-toxic and stable oral composition comprising curcuminoid or its derivative, polyhydric alcohol, amino acids, buffering agent and other pharmaceutically acceptable excipients for enhancing the female sex ratio and improved chances of conception in Bovines. The oral composition is acidic in nature with pH between 4.1-4.6 and in semi-viscous form to enable the availability of the composition in buccal cavity for at least 2-3 minutes. The present invention also provides an economic process for the preparation of said composition.

The invention provides a delayed release dosage form and a bolus configured for administration to an animal, wherein said dosage form and said bolus is configured to release a hydrophobic substance to the animal over a period of time. Preferably the hydrophobic substance is a haloform. Also provided is the use of the delayed release dosage form or bolus of the invention to reduce methane production in a ruminant animal. Also provided is the method of manufacturing a bolus of the invention.

Disclosed is a bolus for oral administration to an animal, the bolus comprising at least one beneficial substance to be delivered to the animal, the bolus comprising two components which are adhered together by a water-soluble adhesive or sealant, such that the two components are separable in vivo, and wherein at least one of the aforesaid components is frangible in vivo, the frangible component being initially stabilised by the adherence thereto of the other of the aforesaid components, such that separation of the two components in vivo facilitates the breakage of the frangible component.

The present invention discloses 2-aminoindane Formulas I and II and their pharmaceutically acceptable salts, compositions and methods of use to modulate central nervous system activity, and to treat central nervous system disorders, such as post-traumatic stress, depression, anxiety, and adjustment disorders. In certain embodiments, the compounds of the present invention can be used for entactogenic therapy in counseling sessions, as needed periodically or consistently as necessary or desired.

Systems and methods provide sugar alcohol to heat stressed ruminants to improve performance. During periods of high temperature or humidity, heat stressed ruminants may exhibit decreased dry matter intake, and in response, an effective amount of sugar alcohol such as sorbitol may be provided in the ruminant diet to cause performance to increase, which may include increased milk yield, improved feed efficiency or both compared to heat stressed dairy cattle without sugar alcohol in the diet.

The present invention provides an intra-ruminal device comprising a body substantially impervious to rumen fluid, the body comprising a barrel, at least one outlet, and at least one matrix in the barrel, a compression arrangement within the body adapted to bias the column of matrices in the barrel to the at least one outlet, and at least one variable geometry device dependent from the body to assist numen retention, wherein the at least one matrix in the barrel comprises at least one active ingredient and at least one polymer selected from the group consisting of a non-ionic polymer and a cross-linked anionic polymer. The invention also provides a method of making and using the device.

Systems and methods provide sugar alcohol to heat stressed ruminants to improve performance. During periods of high temperature or humidity, heat stressed ruminants may exhibit decreased dry matter intake, and in response, an effective amount of sugar alcohol such as sorbitol may be provided in the ruminant diet to cause performance to increase, which may include increased milk yield, improved feed efficiency or both compared to heat stressed dairy cattle without sugar alcohol in the diet.

The present invention relates to an intra-ruminal device comprising a body substantially impervious to rumen fluid, the body comprising a barrel, at least one outlet, at least one matrix comprising at least one active ingredient and at least one clay mineral, a compression arrangement and at least one variable geometry device dependent from the body, use of the intra-ruminal device and a method of treating a ruminant animal by administering the intra-ruminal device to the animal.

There is provided a pellet composition of ruminant feed which reduces the risk of acidosis in the rumen and a process of making such ruminant feed.